ScienceCampus Chronic Inflammation

Comprehensive Center for Chronic Inflammatory Diseases
Since 20 years, the Leibniz-Institute Deutsches Rheuma-Forschungszentrum Berlin (DRFZ) and the Charité – Universitätsmedizin Berlin have established an intimate cooperation for basic research on rheumatic diseases and its translation into clinical reality. We propose to develop this successful cooperation into a comprehensive center for CID, the Leibniz ScienceCampus C3ID, assembling the scientific and clinical excellence of Berlin in this field. Structural elements of this Leibniz ScienceCampus C3ID will be a joint governance, joint appointments of principal investigators, Liaison Research Groups – a unique tool originally developed by the DRFZ and the Charité – joint grant-based research networks, like DFG-funded CRCs, joint educational programs, like the Leibniz Graduate School and a Leibniz Postdoc College on Chronic Inflammation, and cutting-edge biomedical technology platforms and epidemiological expertise located at the DRFZ.
This proposal is based on the scientific understanding that highly similar mechanisms drive inflammatory rheumatic diseases and CID of the brain, the vasculature, the skin, the gut, the pancreas, and other organs. Today, for most of these diseases no cure is available. Comparing the diseases in one integrative research center, the Leibniz ScienceCampus Berlin C3ID, and translating therapeutic concepts from one disease to another, and monitoring their efficacy with cutting-edge biomedical technology, will offer unique chances to identify the drivers of inflammation in each disease, and define innovative ways to block them. Milestones of the research plan are the identification of the cells and mechanisms controlling the chronicity of inflammation in inflammatory diseases of the gut and the skin, neuroinflammation, and inflammatory rheumatic diseases. Further goals are the development of biomarkers and biosignatures identifying the key players, and predicting the response to therapy for a tailored, individualized treatment based on a precision medicine approach. Beyond the scientific perspective, a Leibniz ScienceCampus Berlin C3ID will raise public awareness of CID as a major unmet medical entity and challenge of utmost public relevance, inflicting morbidity and mortality on 5 – 10% of the population.

Project proposal Leibniz ScienceCampus Berlin (short version)

We team up with our local partners:

Charité–Universitätsmedizin Berlin:

  • Klinik für Rheumatologie und Klinische Immunologie, Med. Klinik mit Schwerpunkt Rheumatologie u. Klinische Immunologie
  • Medizinische Klinik I, Medizinische Klinik für Gastroenterologie, Infektiologie, Rheumatologie
  • Experimental and Clinical Research Center (ECRC) and Exzellenzcluster Neurocure
  • Institut für Neuropathologie
  • Charité Centrum Innere Medizin und Dermatologie, Klinik für Dermatologie, Venerologie und Allergologie
  • Charité Centrum Innere Medizin mit Gastroenterologie und Nephrologie, Medizinische Klinik mit Schwerpunkt Nephrologie u. Internist. Intensivmedizin, CVK
  • Charité Centrum Audiologie/Phoniatrie, Augen- und HNO-Heilkunde, CVK

Max Planck Institute for Infection Biology

Artikel zu Entzündung in der Zeitschrift Focus

Contact
Mag. Dr. Elke Luger

Wissenschaftsreferentin

Deutsches Rheuma-Forschungszentrum Berlin (DRFZ)

Ein Institut der Leibniz Gemeinschaft

Chariteplatz 1, 10117 Berlin

T:+49-(0)30-28460-737

M: luger@drfz.de


Direktorium

Prof. Axel Radlach Pries, MD

Dekan
Charité - Universitätsmedizin Berlin

Charitéplatz 1, 10117 Berlin

T: +49 30 450 570 251

M: v-dekan@charite.de


Prof. Andreas Radbruch, PhD

Wissenschaftlicher Direktor

Deutsches Rheuma-Forschungszentrum Berlin

Ein Institut der Leibniz Gemeinschaft 
und
Professor for Experimental Rheumatology,
Charité - Universitätsmedizin Berlin

Charitéplatz 1, 10117 Berlin

T: +49-30-28460-601

M: radbruch@drfz.de

Radbruch Prof. Dr. rer. nat. Andreas Radbruch Cell Biology Triantafyllopoulou_klein Dr. Antigoni Triantafyllopoulou Innate Immunity in Rheumatic Diseases Thurley Dr. Kevin Thurley Systems Biology of inflammation Ahmed Hegazy Dr. med. Dr. rer. nat. Ahmed N. Hegazy Inflammatory Mechanisms Polansky Dr. Julia Polansky-Biskup Immuno-Epigenetics Melchers Prof. Dr. Fritz Melchers Lymphocyte Development Farzin Mashreghi Dr. Mir-Farzin Mashreghi Therapeutic Gene Regulation Kruglov Dr. rer. nat. Andrey Kruglov Chronic Inflammation Loehning Prof. Dr. Max Löhning Pitzer Lab Osteoarthritis Research Kubagawa Prof. Dr. Hiromi Kubagawa Humoral Immune Regulation Hauser Prof. Dr. med. vet. Anja Erika Hauser Immune Dynamics Tokoyoda Dr. Koji Tokoyoda Osteoimmunology Scheffold Prof. Dr. rer. nat. Alexander Scheffold Cellular Immunology Niesner Dr. rer. nat. Raluca Niesner Biophysical Analytics Strangfeld Dr. med. Anja Strangfeld Pharmacoepidemiology Minden Prof. Dr. med. Kirsten Minden Paediatric Rheumatology Listing Dr. Joachim Listing Statistics & Clinical Studies Angela_Zink_230x230 Prof. Dr. Angela Zink Health Services Research Worm Prof. Dr. med. Margitta Worm Allergology Poddubnyy Prof. Dr. Denis Poddubnyy Spondyloarthritides Riemekasten Prof. Dr. med. Gabriela Riemekasten Cell Autoimmunity Hiepe Prof. Dr. med. Falk Hiepe Autoimmunology Hamann Prof. Dr. rer. nat. Alf Hamann Experimental Rheumatology Doerner Prof. Dr. med. Thomas Dörner B Cell Memory Buttgereit Prof. Dr. med. Frank Buttgereit Glucocorticoids & Bioenergetics Romagnani Prof. Dr. Chiara Romagnani Innate Immunity Hutloff Dr. rer. nat. Andreas Hutloff Chronic Immune Reactions Fillatreau Prof. Dr. rer. nat. Simon Fillatreau Immune Regulation Baumgrass Prof. Dr. Ria Baumgrass Signal Transduction Nedospasow Prof. Dr. Sergei Nedospasov Inflammation Biology