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Dr. Edda Schulz: Role and control of X-chromosomal dosage

25.6.2018

Role and control of X-chromosomal dosage
Dr. Edda Schulz

Regulatory Networks in Stem Cells, Max-Planck-Institut für molekulare Genetik, Berlin

In female mammals, dosage compensation for X-linked genes is ensured through random X-chromosome inactivation mediated by the long non-coding RNA Xist. During this process most genes are silenced on one randomly chosen X-chromosome. In embryonic stem cells however, where both X-chromosomes are active, double X-dosage affects pluripotency and differentiation through inhibiting the MAPK signaling pathway. We combine theoretical and experimental approaches to understand how X-dosage information will drive cellular decision making processes.

Dr. Edda Schulz
Max Planck Forschungsgruppe Regulatorische Netzwerke in Stammzellen
Max-Planck-Institut für molekulare Genetik
Ihnestraße 63, 14195 Berlin
Tower 4, Room 2.210/2.212
Phone: +49 30 8413-1226

Edda Schulz