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Urine Biomarkers – immune cells indicate kidney inflammation

A serious complication of systemic lupus erythematosus (SLE) is kidney inflammation. These publications show that cells of the immune system in the urine indicate the local inflammation of the kidney. These cells cannot be found in the blood. Using a special type of cell measurement, mass cytometry, the cells from the urine were examined in detail (publication 1). It was shown that they indicate the type and severity of the inflammation. They also indicate the start of kidney transplant rejection (publication 2). Further analysis will now clarify whether these cells from the urine also predict how well SLE patients respond to immunosuppressive therapies.

publication 1
Deep Phenotyping of Urinary Leukocytes by Mass Cytometry Reveals a Leukocyte Signature for Early and Non-Invasive Prediction of Response to Treatment in Active Lupus Nephritis.
Bertolo M, Baumgart S, Durek P, Peddinghaus A, Mei H, Rose T, Enghard P, Grützkau A.
Front Immunol. 2020 Mar 24;11:256. doi: 10.3389/fimmu.2020.00256. eCollection 2020.
PMID: 32265898
publication 2
Kidney transplant monitoring by urinary flow cytometry: Biomarker combination of T cells, renal tubular epithelial cells, and podocalyxin-positive cells detects rejection.
Goerlich N, Brand HA, Langhans V, Tesch S, Schachtner T, Koch B, Paliege A, Schneider W, Grützkau A, Reinke P, Enghard P.
Sci Rep. 2020 Jan 21;10(1):796. doi: 10.1038/s41598-020-57524-7.
PMID: 31964937
Immune Monitoring || Regine von Ramin Lab Molecular Rheumatology Dr. rer. nat. Andreas Grützkau Phone +49 (0)30 28460-690 gruetzkau@drfz.de more
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