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DRFZ versus SARS-CoV2

At the Leibniz Institute German Rheumatism Research Center Berlin, interdisciplinary scientists investigate the basics of immunity and autoimmunity, i.e. the difference between protective and harmful immune reactions. The DRFZ is one of the world’s leading research institutes in the fields of antibody-producing plasma cells and B lymphocytes, innate lymphocytes, T lymphocytes and immunological memory, i.e. long-term immunity. Unique technologies for research on immune reactions have been developed here. This expertise is now offered for research on SARS-CoV2 immunity and immunopathology, in collaboration with virological and clinical research groups.

SARS-CoV2 is a challenge for everyone

Here is an overview of the DRFZ’s technological expertise, a unique arsenal for the diagnosis of Covid-19 immunity and the generation of monoclonal antibodies against SARS-Cov2:

  • Platforms for identification, isolation, analysis and use of single human immune cells from blood and tissue (fluorescence-based and mass cytometry, fluorescence-based and magnetic cell sorting (MACS technology))
  • The DRFZ has developed worldwide unique methods for the identification of inflammation-associated monocytes (Siglec-1), virus-specific NK cells, reactive T lymphocytes (ARTE technology), reactive B lymphocytes and plasma cells (HLA-DR).
  • Platform for global investigation of such cells on single-cell level (single-cell omics, CITE-Seq, antigen receptor repertoire, bioinformatics)

Contact at  the DRFZ

Dr. Mir-Farzin Mashreghi
Deutsches Rheuma-Forschungszentrum Berlin
Lab Therapeutic Gene Regulation
Charitéplatz 1 – Campus der Charité Mitte
10117 Berlin

The Corona virus and our immune system

Prof. Andreas Radbruch explains how exactly the corona virus affects the body, which type of drug search would probably be the fastest and what can be learned from corona cases in China and Australia in a podcast initiated by the Leibniz Association and t-online.de in conversation with moderator Ursula Weidenfeld:

Podcast: Tonspur Wissen – Corona-Questions to Andreas Radbruch

The outbreak and spread of the coronavirus changes the whole life. Many people have questions, scientists can provide answers – and from now on they will do so every day in the podcast “Tonspur Wissen”.

Corona Podcast

Volume 4: Corona-Frage an Prof. Andreas Radbruch: Wie reagiert das Immunsystem auf das Coronavirus? (in German only)
To the podcast of t-online.de and the Leibniz Association
Reference: www.leibniz-gemeinschaft.de

Contact

Therapeutic Gene Regulation || Regine von Ramin Lab Molecular Rheumatology || BCRT/DRFZ Single-Cell Laboratory for Advanced Cellular Therapies Dr. Mir-Farzin Mashreghi Phone +49 (0)30 28460-752 mashreghi@drfz.de more
Scientific Director Prof. Dr. Andreas Radbruch Phone +49 (0)30 28 460-601 durez@drfz.de more