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Distinct microbiota can induce antibodies to SARS-CoV-2

The research group of Andrey Kruglov has now published evidence that distinct bacteria of the oral and gut microbiome can stimulate the immune system to make protective antibodies against the receptor-binding domain of the spike protein of SARS-CoV-2. The bacteria make proteins imitating this antigen. Individuals with these bacteria in their microbiome already have protective antibodies if they get infected with SARS-CoV-2. Presumably they will be less likely to get severe COVID-19. One of these bacteria is already in use as probiotic: Streptococcus salivarius.

Induction of cross-reactive antibody responses against the RBD domain of the spike protein of SARS-CoV-2 by commensal microbiota“, (preprint)
Justus Ninnemann, Lisa Budzinski, Marina Bondareva, Mario Witkowski, Stefan Angermair, Jakob Kreye, Pawel Durek, S. Momsen Reincke, Elisa Sánchez-Sendin, Selin Yilmaz, Toni Sempert, Gitta Anne Heinz, Caroline Tizian, Martin Raftery, Günther Schönrich, Daria Matyushkina, Ivan V. Smirnov, Vadim M. Govorun, Eva Schrezenmeier, Thomas Dörner, Silvia Zocche, Edoardo Viviano, Katharina Johanna Sehmsdorf, Hyun-Dong Chang, Philipp Enghard, Sascha Treskatsch, Andreas Radbruch, Andreas Diefenbach, Harald Prüss, Mir-Farzin Mashreghi, Andrey A. Kruglov
Chronic inflammation Dr. Andrey Kruglov Phone +49 (0)30 28460-641/643 kruglov@drfz.de more
Therapeutic Gene Regulation || Regine von Ramin Lab Molecular Rheumatology || BCRT/DRFZ Single-Cell Laboratory for Advanced Cellular Therapies Dr. Mir-Farzin Mashreghi Phone +49 (0)30 28460-752 mashreghi@drfz.de more
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