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Kidney transplant and dialysis patients have poor responses to COVID-19 vaccines

COVID-19 vaccinations have shown remarkable protection against SARS-CoV-2 infection in individuals around the world.  However, recent evidence has suggested that immune compromised and organ transplant patients have poor immune responses to COVID-19 vaccines. Hector Rincon-Arevalo, Eva Schrezenmeier, Thomas Dörner and colleagues looked at antibody, plasmablast, and memory B cell responses in healthy, dialysis, and kidney transplant patients before and after the COVID-19 mRNA BNT162b2 vaccine.  They found that patients had poor antibody and B cell responses to the vaccine, suggesting these patients may not be sufficiently protected against SARS-CoV-2 infection.  Thus, different vaccine strategies need to be developed to sufficiently protect dialysis and kidney transplant patients against COVID-19.

Impaired humoral immunity to SARS-CoV-2 BNT162b2 vaccine in kidney transplant recipients and dialysis patients
H Rincon-Arevalo, M Choi, A-L Stefanski, F Halleck, U Weber, F Szelinski, B Jahrsdörfer, H Schrezenmeier, C Ludwig, A Sattler, K Kotsch, A Potekhin, Y Chen, G . Burmester, K-U Eckardt, G M Guerra, P Durek, F Heinrich, M Ferreira-Gomes, A Radbruch, K Budde, A C. Lino, M-F Mashreghi, Eva Schrezenmeier, Thomas Dörner. Impaired humoral immunity to SARS-CoV-2 BNT162b2 vaccine in kidney transplant recipients and dialysis patients. Science Immunology 15 Jun 2021, Vol. 6, Issue 60, eabj1031, DOI: 10.1126/sciimmunol.abj1031
B-cell memory Prof. Dr. med. Thomas Dörner Phone +49 (0)30 450 525 241 thomas.doerner@charite.de more
Therapeutic Gene Regulation || Regine von Ramin Lab Molecular Rheumatology || BCRT/DRFZ Single-Cell Laboratory for Advanced Cellular Therapies Dr. Mir-Farzin Mashreghi Phone +49 (0)30 28460-752 mashreghi@drfz.de more
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Scientific Director Prof. Dr. Andreas Radbruch Phone +49 (0)30 28 460-601 durez@drfz.de more
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