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Tissue-resident T Lymphocytes differ from those in the blood

It has not been understood until now how memory lymphocytes – the cells of the immune system that make us immune to previously encountered infections – survive, and how they can drive chronic inflammation. In this publication, we show that there are memory T lymphocytes that circulate through the body via the blood, but there are also memory T lymphocytes that are only found in specific tissues, such as the bone marrow. These cells differ in function and survival strategy, an important piece of information when it comes to specifically eliminating certain T lymphocytes in order to treat rheumatic inflammation while preserving the patient’s immune system.

publication
Francesco Siracusa, Pawel Durek, Mairi A. McGrath, Özen Sercan‐Alp, Anna Rao, Weijie Du, Carla Cendón, Hyun‐Dong Chang, Gitta Anne Heinz, Mir‐Farzin Mashreghi, Andreas Radbruch, Jun Dong. CD69 + memory T lymphocytes of the bone marrow and spleen express the signature transcripts of tissue-resident memory T lymphocytes. First published: 23 January 2019, doi.org/10.1002/eji.201847982|
Leitung
Scientific Director Prof. Dr. Andreas Radbruch Phone +49 (0)30 28 460-601 durez@drfz.de more
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