Home Latest News News Wie Stromazellen das Immunsystem im Knochenmark organisieren und so auch chronische rheumatische Entzündungen antreiben
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How stromal cells organise the immune system in the bone marrow and thus drive chronic rheumatic inflammation

In chronic inflammatory rheumatic diseases, the patient’s immune system attacks its own body with cytokines and antibodies. The immune cells producing these cytokines and antibodies are located in the inflamed tissue, as well as in the bone marrow. Here, stromal cells protect them against conventional therapies. If we understand how this protection works, we could treat rheumatic inflammation causally. This publication is the first to show how stromal cells specialise in supporting the survival of specific immune cells. This is crucial for developing new therapies against the immune cells hiding in the bone marrow driving chronic inflammation.

Single-cell transcriptomes of murine bone marrow stromal cells reveal niche-associated heterogeneity.
Addo RK, Heinrich F, Heinz GA, Schulz D, Sercan-Alp Ö, Lehmann K, Tran CL, Bardua M, Matz M, Löhning M, Hauser AE, Kruglov A, Chang HD, Durek P, Radbruch A, Mashreghi MF.
Eur J Immunol. 2019 Sep;49(9):1372-1379. doi: 10.1002/eji.201848053. Epub 2019 Jun 7.
PMID: 31149730
Leitung Portrait von Prof. Dr. rer. nat. Andreas Radbruch
Scientific Director Prof. Dr. Andreas Radbruch Phone +49 (0)30 28 460-601 durez@drfz.de more
Therapeutic Gene Regulation || Regine von Ramin Lab Molecular Rheumatology || BCRT/DRFZ Single-Cell Laboratory for Advanced Cellular Therapies Dr. Mir-Farzin Mashreghi Phone +49 (0)30 28460-752 mashreghi@drfz.de more
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