Worm lab

Novel therapeutic approaches of type I-allergy by immunomodulation

Introduction
Members
Cooperation partners
Selected Publications
Third party funding projects

Allergology

The “Allergology” group is focused on immunomodulation of IgE-dependent type I allergies. Currently, approx. 20% of the German population are affected by hay fever, allergic asthma or atopic dermatitis. Our research is focused on the understanding of molecular and cellular key events for the development and maintenance of IgE production. Special interests among our group include immunomodulatory functions of nuclear receptor ligands mechanisms of specific immunotherapy anaphylaxis and regulation of skin homeostasis.

Nuclear receptor ligands include molecules like vitamin D and retinoids. We have shown that vitamin D profoundly modulates B cell activation and hampers the IgE response. Currently, we are studying molecular and cellular signalling in detail and we have also initiated a clinical translation program. In these studies, we target vitamin D receptors in immune cells in vivo and determine the impact on specific allergic symptoms. Our overall aim is to achieve long-term tolerance to allergens.

The studies on specific immunotherapy anaphylaxis and regulation of skin homeostasis include the investigation of patient cohorts upon treatment or reaction (bedside). However, the application of targeted mouse models enables us to set up models with targeted deletion of specific mediators and their receptors to unravel mechanistic functions upon defined pathophysiological conditions.

The overall aim of our research is to develop novel strategies for innovative treatment protocols in allergy. We transfer our experimental data into clinical trials.

Group Leader
    Prof. Dr. med. Margitta Worm

Prof. Dr. med. Margitta Worm

Allergie-Centrum-Charité
Klinik für Dermatologie, Venerologie und Allergologie
Charité Campus Mitte, Universitätsmedizin Berlin
Charitéplatz 1
10117 Berlin
Germany

Phone +49 (0)30 450 518 105
Fax +49 (0)30 450 518 958
margitta.worm@charite.de
Charité Homepage

Keywords
Allergy
B-cells
Immune modulation
Anaphylaxis

Continue to Members

Group leader
Prof. Dr. med. Margitta Worm

Scientists
Dr. Guido Heine, Dr. Kristin Franke
Dr. Sabine Dölle, Dr. Magda Babina
Dr. Vandana Kumari, Dr. Maria Nassiri

PhD students
Davender Davender, Tina Krause, Juliane Lindner, Tarek Hazzan, Shruti Rastogi, Wojciech Francuzik, Maria Michaelidou, Josephine Scholz, Aida Abadpour

Bachelor/Diploma/Master students
Nora Schumacher, Jana Hallau, Bianca Lötzsch, Nadine Hielscher, Elvira Ruppel, Oliver Eckermann, Juliane Schulz, Helen Schlachta, Theresa Bartholomäus,
Kathleen Winkel, Annika Lahl, Kristina Heins, Aida Abadpour, Wojciech Francuzik, Tarek, Mandana Schindler,
Marcel Wittenberg

Technicians
Dennis Ernst

Group Leader
    Prof. Dr. med. Margitta Worm

Prof. Dr. med. Margitta Worm

Allergie-Centrum-Charité
Klinik für Dermatologie, Venerologie und Allergologie
Charité Campus Mitte, Universitätsmedizin Berlin
Charitéplatz 1
10117 Berlin
Germany

Phone +49 (0)30 450 518 105
Fax +49 (0)30 450 518 958
margitta.worm@charite.de
Charité Homepage

Keywords
Allergy
B-cells
Immune modulation
Anaphylaxis

Continue to Cooperation partners

Prof. René St. Arnaud, Shriners Hospital for Children, Genetics Unit, Montréal, Canada

Prof. Dr. rer. nat. Ria Baumgrass, Deutsches Rheuma-Forschungszentrum Berlin, Cell signaling group, Berlin

Prof. Dr. med. Thomas Dörner, Med. Klinik mit Schw. Rheumatologie und Klinische Immunologie, Charité – Universitätsmedizin Berlin, Germany

Prof. Dr. phil. nat. Hermann Eibel, Center for Chronic Immunodeficiency, Universitätsklinikum Freiburg, Germany

Prof. Dr. vet. Reinhold Erben, Universität für Tiermedizin, Institut für Pathophysiologie, Wien, Österreich

PD Dr. rer. nat. Lutz Hamann, Charité – Universitätsmedizin Berlin, Institut für Mikrobiologie und Hygiene CCM, Germany

Prof. Dr. rer. nat. Susanne Hartmann, Institut für Immunologie, FB Veterinärmedizin, Freie Universität Berlin, Germany

Dr. rer. nat. Andreas Hutloff, PhD, Deutsches Rheuma-Forschungszentrum Berlin, Germany

Prof. Dr. med. Bastian Opitz, Prof. Dr. med. Martin Witzenrath, Christoph Tabeling, Charité – Universitätsmedizin Berlin, Med. Klinik mit Schw. Infektiologie und Pneumologie, Germany

Prof. Dr. med. Harald Renz, Philipps-University of Marburg, Dept of Clinical Chemistry and Molecular Diagnostics, Marburg, Germany

Prof. Dr. rer. nat. Michael Reth, MPI Immunbiology and Epigenetics, Freiburg, Germany

Prof. Dr. med. Birgit Sawitzki, Charité – Universitätsmedizin Berlin, Institut für Medizinische Immunologie, Germany

Prof. Dr. rer. nat. Alexander Scheffold, Deutsches Rheuma-Forschungszentrum Berlin, Germany

Prof. Dr. med. Ralf Schumann, PD Lutz Hamann, Charité – Universitätsmedizin Berlin, Institut für Mikrobiologie und Hygiene, Berlink, Germany

Prof. Dr. med. Hans-Dieter Volk, Charité – Universitätsmedizin Berlin, Klinik für Medizinische Immunologie, Germany

Group Leader
    Prof. Dr. med. Margitta Worm

Prof. Dr. med. Margitta Worm

Allergie-Centrum-Charité
Klinik für Dermatologie, Venerologie und Allergologie
Charité Campus Mitte, Universitätsmedizin Berlin
Charitéplatz 1
10117 Berlin
Germany

Phone +49 (0)30 450 518 105
Fax +49 (0)30 450 518 958
margitta.worm@charite.de
Charité Homepage

Keywords
Allergy
B-cells
Immune modulation
Anaphylaxis

Continue to Selected Publications
  • Moinzadeh P, et al. (2015). Disease progression in systemic sclerosis-overlap syndrome is significantly different from limited and diffuse cutaneous systemic sclerosis. Ann Rheum Dis. 74(4):730-7.
  • Grabenhenrich LB, et al. (2016). Anaphylaxis in children and adolescents: The European Anaphylaxis Registry. J Allergy Clin Immunol. Apr;137(4):1128-37.e1.
  • Bacher P, et al. (2016). Regulatory T Cell Specificity Directs Tolerance versus Allergy against Aeroantigens in Humans. Cell. Nov 3;167(4):1067-1078.e16.
  • Thaçi D, et al. (2016). Efficacy and safety of dupilumab in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical treatments: a randomised, placebo-controlled, dose-ranging phase 2b trial. Lancet. Jan 2;387(10013):40-52.
  • Heine G, et al. (2018). 9-cis retinoic acid modulates the type I allergic immune response. J Allergy Clin Immunol. 141(2):650-658.
Group Leader
    Prof. Dr. med. Margitta Worm

Prof. Dr. med. Margitta Worm

Allergie-Centrum-Charité
Klinik für Dermatologie, Venerologie und Allergologie
Charité Campus Mitte, Universitätsmedizin Berlin
Charitéplatz 1
10117 Berlin
Germany

Phone +49 (0)30 450 518 105
Fax +49 (0)30 450 518 958
margitta.worm@charite.de
Charité Homepage

Keywords
Allergy
B-cells
Immune modulation
Anaphylaxis

Continue to Third party funding projects
Title of the project / project number
Runtime
SFB 650 TP 5 2013 – 2016
WO 541/14-1 2013 – 2016
TRR-130 TP 19 2013 – 2017
WO 541/16-1 2015 – 2017
WO 541/13-2 2015 -2018

Industry

Title of the project Runtime
Compliance und Lebensqualität (CELL) bei PSS-Patienten – Entwicklung eines strukturierten Schulungsprogramms 2016 –2018
OP-DTI-SEKT 2017 –2018
Einfluss von LC-PUFA auf die Ausprägung der allergischen Immunantwort im Mausmodell Until end of 2017
Group Leader
    Prof. Dr. med. Margitta Worm

Prof. Dr. med. Margitta Worm

Allergie-Centrum-Charité
Klinik für Dermatologie, Venerologie und Allergologie
Charité Campus Mitte, Universitätsmedizin Berlin
Charitéplatz 1
10117 Berlin
Germany

Phone +49 (0)30 450 518 105
Fax +49 (0)30 450 518 958
margitta.worm@charite.de
Charité Homepage

Keywords
Allergy
B-cells
Immune modulation
Anaphylaxis

Continue to Introduction