The Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) is the central, independent research funding organisation in Germany. It serves all branches of science and the humanities by funding research projects at universities and other research institutions.
The aim of the Transregional Collaborative Research Centre TRR130 B cells: Immunity and Autoimmunity is to gain a better understanding of the role of B lymphocytes in physiological immune reactions and in chronic inflammatory diseases.
The DRFZ contributes to this consortium with its expertise in the field of memory B lymphocytes, especially memory plasma cells, in a biomedical and clinical context.
Furthermore, it provides optical technology development, i.e. flow cytometry and intravital microscopy.
PIs at the DRFZ:
Andreas Radbruch (Co-Speaker), Ria Baumgrass, Hyun-Dong Chang, Thomas Dörner, Andreas Grützkau, Anja Hauser, Guido Heine, Falk Hiepe, Max Löhning, Mir-Farzin Mashreghi, Raluca Niesner, Chiara Romagnani, Margita Worm
The DFG Priority Programme SPP 1937 Innate Lymphoid Cells is a national, interdisciplinary priority programme for the structured funding of research groups conducting joint research in the new scientific field of the Innate Lymphoid Cells (ILCs).
ILCs are a group of lymphocytes of the innate immune system discovered recently. They are important effector cells in the immune defense of infections and tumors. However, they are also involved in the pathogenesis of various inflammatory diseases such as chronic inflammatory bowel diseases, rheumatoid arthritis etc..
It is now also known that ILCs are tissue-resident cells that strongly impact on the biology of various organs and tissues.
Three research groups at the DRFZ are investigating the interaction between ILCs and the surrounding tissue in order to gain an understanding of the development of chronic inflammatory diseases.
The etiological background of Inflammatory Bowel Diseases (IBD: Crohn’s disease, ulcerative colitis) is still poorly understood, in particular the local cellcell interactions. The driving hypothesis behind this new joint initiative is that a dysregulated signal exchange between the epithelium and immune cells and the consequences thereof contribute to the pathogenesis of IBD.
The DRFZ focuses on how the crosstalk of intestinal microbiota and immune cells can affect intestinal barrier functions and on how mechanisms of the innate immune system can initiate inflammation or, in contrast, lead to epithelial protection and barrier repair.
Die Forschungsgruppe untersucht die Mechanismen der Regeneration von Knochen und Knorpel nach Schädigungen. Insbesondere die frühe Immunantwort und Wiederherstellung der mechanischen Kompetenz im Hinblick auf ihre Veränderung im Alter stehen dabei im Vordergrund. Im am DRFZ durchgeführten Teilprojekt 7 werden osteo-immunologische Interaktionen im Verlauf der Frakturheilung mit Hilfe von longitudinalem Intravital-Imaging analysiert.
Ansprechpartner im DRFZ:
Expired projects in 2020
Mass cytometry (CyTOF technology) is a new technology that captures the complexity of cellular systems in unprecedented detail and promises significant contributions in biomedical diagnostics and research. The DRFZ initiated the establishment of the nationwide German Mass Cytometry Network GERMANET for mass cytometry in Germany: The aim is to bring together the expertise of all German mass cytometry centres.
Contact person at the DRFZ: