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Thurley lab

Understanding the complex relationships among immune cells with mathematical tools

Introduction
Members
Cooperation partners
Selected Publications

Systems Biology of inflammation

Analysis of complex networks requires mathematical methods. Our research group uses modeling and data analysis techniques to investigate the regulation of immune responses. We use kinetic, spatial and stochastic modeling techniques, and we analyze high-dimensional data such as from single-cell sequencing and multi-color flow cytometry and histology, in tight collaboration with experimental collaboration partners. Overall, the goal of the group is to develop an interdisciplinary framework for dissecting and rationalizing intercellular communication networks, to investigate the effects of perturbations and thus pave the road for optimization of targeted therapies in the future.

Keywords

Data-driven modeling
Spatial and stochastic models
High-dimensional data analysis
Cell-cell communication networks

Systems Biology of Inflammation Dr. Kevin Thurley Phone +49 30 28460 734 kevin.thurley@drfz.de more
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Group leader
Dr. Kevin Thurley

Members

Philipp Burt, Msc Biophysics (PhD student)

Gino Kwon, Msc Nano Medical Science (PhD student)

Patrick Brunner, Msc Biophysics (PhD student)

Lukas Kiwitz (Bsc student, HU Biology)

Continue to Cooperation partners

Charité-Universitätsmedizin Berlin:
Prof. Thomas Dörner
Prof. Ahmed Hegazy
Prof. Max Löhning
Prof. Andreas Radbruch
Prof. Chiara Romagnani
Prof. Antigoni Triantafyllopoulou

MPI für Infektionsbiologie, Berlin:
Dr. Marcus Taylor

Universitätsklinikum Schleswig-Holstein, Kiel:
Prof. Andreas Hutloff

University of California San Francisco:
Prof. Steven Altschuler
Prof. Orion Weiner
Prof. Lani Wu

Continue to Selected Publications

Hammer Q, Rückert T, Borst EM, Dunst J, Haubner A, Durek P, Heinrich F, Gasparoni G, Babic M, Tomic A, Pietra G, Nienen M, Blau IW, Hofmann J, Na IK, Prinz I, Koenecke C, Hemmati P, Babel N, Arnold R, Walter J, Thurley K, Mashreghi MF, Messerle M, Romagnani C. Peptide-specific recognition of human cytomegalovirus strains controls adaptive natural killer cells. Nat Immunol. 19(5):453-63 (2018).

Thurley K, Wu LF, Altschuler SJ. Modeling cell-to-cell communication networks using response-time distributions. Cell Systems 6:355 (2018).

Thurley K, Herbst C, Wesener F, Koller B, Wallach T, Maier B, Kramer A, Westermark PO. Principles for circadian orchestration of metabolic pathways. PNAS (2017).

Diz-Muñoz A, Thurley K, Chintamen S, Altschuler SJ, Wu LF, Fletcher DA, Weiner OD. Membrane Tension Acts Through PLD2 and mTORC2 to Limit Actin Network Assembly During Neutrophil Migration. PLoS Biol 14(6):e1002474 (2016).

Thurley K, Gerecht D, Friedmann E, Höfer T. Three-Dimensional Gradients of Cytokine Signaling between T Cells. PLoS Comput Biol 11(4):e1004206 (2015).

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