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Chronic Immune Reactions
Univ.-Prof. Dr. Andreas Hutloff

Chronic Immune Reactions

Univ.-Prof. Dr. Andreas Hutloff

Univ.-Prof. Dr. Andreas Hutloff
Institute of Immunology and Institute of Clinical Molecular Biology
University Hospital Schleswig-Holstein
Arnold-Heller-Str. 3
24105 Kiel, Germany
Phone: +49 (0)30 28460-792 Fax: +49 (0)30 28460-603 hutloff@drfz.de

CV and Key Publications

Scientific Career
  • March 2020 Following call for professorship at Christian-Albrechts University in Kiel
  • Since 2009 Group Leader, DRFZ, Berlin
  • 2004 – 2008 Group Leader, Robert Koch Institute, Berlin
  • 1999 – 2004 Postdoctoral Fellow, Robert Koch Institute, Berlin
  • 1995 – 1999 Doctoral thesis, Robert Koch Institute, Berlin (Prof. R.A. Kroczek)
  • 1999 Dr. rer. nat., Free University Berlin
  • 1995 Diploma thesis, Bernhard Nocht Institute for Tropical Medicine (Prof. B. Fleischer)
  • 1990 – 1995 Studies in Biochemistry/Molecular Biology, University Hamburg
Third Party Funding

Selection (from 2011 – ongoing)

  • 2018 – 2021 Lung-resident memory T cells and their role for the reactivation of antigen-specific B cells (DFG individual grant)
  • 2017 – 2021 Germinal center-like B cells in inflamed tissues (DFG CRC TRR 130)
  • 2016 – 2019 Molecular regulation of T follicular helper cell maintenance by Bach2 and RankL (DFG individual grant)
  • 2015 – 2017 The Inducible T cell Co-Stimulator ICOS as target for elimination of tissue-resident follicular helper-like T cells (Fritz Thyssen Foundation)
  • 2011 – 2014 The role of ICOS for T follicular helper responses (DFG individual grant)
Key Publications
  1. Lahmann A, Kuhrau J, Fuhrmann F, Heinrich F, Bauer L, Durek P, Mashreghi MF, Hutloff A. Bach2 Controls T Follicular Helper Cells by Direct Repression of Bcl-6. J Immunol. 2019 202(8):2229-39.
  2. Hutloff A. T follicular helper-like cells in inflamed non-lymphoid tissues. Front Immunol. 2018 9:1707.
  3. Vu Van D, Bauer L, Kroczek RA, Hutloff A. ICOS costimulation differentially affects T cells in secondary lymphoid organs and inflamed tissues. Am J Respir Cell Mol Biol. 2018 59(4):437-47.
  4. Ugolini M, Gerhard J, Burkert S, Jensen KJ, Georg P, Ebner F, Volkers SM, Thada S, Dietert K, Bauer L, Schafer A, Helbig ET, Opitz B, Kurth F, Sur S, Dittrich N, Gaddam S, Conrad ML, Benn CS, Blohm U, Gruber AD, Hutloff A, Hartmann S, Boekschoten MV, Muller M, Jungersen G, Schumann RR, Suttorp N, Sander LE. Recognition of microbial viability via TLR8 drives TFH cell differentiation and vaccine responses. Nat Immunol. 2018 19(4): 386-96.
  5. Vu Van D, Beier KC, Pietzke LJ, Al Baz MS, Feist RK, Gurka S, Hamelmann E, Kroczek RA, Hutloff A. Local T/B cooperation in inflamed tissues is supported by T follicular helper-like cells. Nat Commun. 2016 7:10875.
  6. Weber JP, Fuhrmann F, Feist RK, Lahmann A, Al Baz MS, Gentz LJ, Vu Van D, Mages HW, Haftmann C, Riedel R, Grün JR, Schuh W, Kroczek RA, Radbruch A, Mashreghi MF, Hutloff A. ICOS maintains the T follicular helper cell phenotype by down-regulating Krüppel-like factor 2. J Exp Med. 2015 212(2):217-33.
  7. Weber JP, Fuhrmann F, Hutloff A. Frontline: T-follicular helper cells survive as long-term memory cells. Eur J Immunol. 2012 42(8):1981-8.
  8. Hutloff A, Büchner K, Reiter R, Baelde HJ, Odendahl M, Jacobi A, Dörner T, Kroczek RA. Involvement of Inducible costimulator in the exaggerated memory B cell and plasma cell generation in systemic lupus erythematosus. Arthritis Rheum. 2004 50(10):3211-20.
  9. Grimbacher B,* Hutloff A * (equal contribution), Schlesier M, Glocker E, Warnatz K, Dräger R, Eibel H, Fischer B, Schäffer AA, Mages HW, Kroczek RA*, Peter HH*. Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency. Nat Immunol. 2003 4(3):261-8.
  10. Hutloff A, Dittrich AM, Beier KC, Eljaschewitsch B, Kraft R, Anagnostopoulos I, Kroczek RA. ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. Nature. 1999 397(6716):263-6.
Hutloff lab
When T cell / B cell crosstalk fails