{"id":2980,"date":"2025-01-24T11:02:32","date_gmt":"2025-01-24T11:02:32","guid":{"rendered":"https:\/\/www.drfz.de\/?post_type=head&#038;p=2980"},"modified":"2025-05-12T07:28:44","modified_gmt":"2025-05-12T07:28:44","slug":"falk-hiepe","status":"publish","type":"head","link":"https:\/\/www.drfz.de\/en\/koepfe\/falk-hiepe\/","title":{"rendered":"Prof. Dr. med. Falk Hiepe"},"content":{"rendered":"\n  <section id=\"scientific-background\"\n           class=\"section accordion  alignwide  toc-item\"\n           data-open=\"multiple\">\n    <div class=\"container container--center container--medium\">\n              <h2 class=\"h3 section__heading launimation slideBottom\">Scientific Background<\/h2>\n      \n      \n      \n              <div id=\"panel-\"\n             class=\"accordion__category active\" role=\"tabpanel\"\n             aria-labelledby=\"tab-\">\n                    <script type=\"application\/ld+json\">\n            {\n              \"@context\": \"https:\/\/schema.org\",\n              \"@type\": \"FAQPage\",\n              \"mainEntity\": [{\"@type\": \"Question\",\"name\": \"Scientific Career\",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"Since 2019 Senior Professor, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin\n1997-2019 Full Professor of Rheumatology and Clinical Immunology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin\n1997-2024 Group Leader German Rheumatology Research Center Berlin, a Leibniz Institute, Autoimmunology Group\n1993-2019 Deputy Director, Department of Rheumatology and Clin. Immunology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin\n1995 Research Fellow, W. M. Keck Autoimmune Disease Center (Head: E.M. Tan), The Scripps Research Institute, La Jolla, CA, USA\n1988 Completed postdoctoral dissertation (habilitation, prerequisite for professorship) at the Humboldt University in Berlin\n1987 Visiting Professor at the Second Dept. of Medicine, Teikyo University and Department of Medicine; Physical Therapy (Kazuhiko Yamamoto\u2019s Lab), University of Tokyo, Japan\n1977 degree thesis (Dr. med.), Faculty of Medicine, Humboldt University, Berlin)\n1976 Diploma (Dipl.-Med.), Faculty of Medicine, Humboldt University, Berlin\"}},{\"@type\": \"Question\",\"name\": \"Education\",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"1994 Specialization in Rheumatology\n1983 Specialization in Internal Medicine\n1978-1983 Resident Department of Internal Medicine, Charit\u00e9 Berlin, Germany\n1971-1976 Study of Medicine, Humboldt-University Berlin, Germany\"}},{\"@type\": \"Question\",\"name\": \"Professional Activities\",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"Since 2014 Chair,\u00a0 Deutsche Gesellschaft f\u00fcr Lupus-Forschung\nSince 2000 IUIS\/WHO\/AF\/CDC Committee for the Standardization of Autoantibodies in Rheumatic and Related Disease,\nInternational Advisory Board of Modern Rheumatology,\nThe Japan Rheumatism Association\nSpeaker, Arbeitskreis \u201eExtrakorporale Therapieverfahren und Stammzelltherapie\u201c, DGRh\n2002-2014 Drug Commission of the German Medical Associatio\"}},{\"@type\": \"Question\",\"name\": \"Society Memberships\",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"The German Society for Rheumatology,\nThe German Society for Immunology,\nThe Henry Kunkel Society, Deutsche Gesellschaft f\u00fcr Lupus-Forschung,\nEBMT working party \u201cautoimmune diseases\u201d,\nRheuma-Liga Berlin e.V., Gesellschaft f\u00fcr Natur- und Heilkunde in Berlin,\nGesellschaft zur F\u00f6rderung der Immundiagnostik e.V.,\nFreunde und F\u00f6rderer der Charit\u00e9\"}},{\"@type\": \"Question\",\"name\": \"Fellowships and Awards\",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"Award Wolfgang-Schulze Foundation,\nEULAR-award of EWRR,\nIdeenwettbewerb Deutsche Rheumastiftung,\nHumboldt Award for Best Diploma,\nResearch Award Charit\u00e9 Hospital\"}}]\n            }\n          <\/script>\n\n          <div class=\"accordion__content\">\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69ddfc050f6d8_0\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">Scientific Career<\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69ddfc050f6d8_0\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p>Since 2019 Senior Professor, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin<br \/>\n1997-2019 Full Professor of Rheumatology and Clinical Immunology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin<br \/>\n1997-2024 Group Leader German Rheumatology Research Center Berlin, a Leibniz Institute, Autoimmunology Group<br \/>\n1993-2019 Deputy Director, Department of Rheumatology and Clin. Immunology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin<br \/>\n1995 Research Fellow, W. M. Keck Autoimmune Disease Center (Head: E.M. Tan), The Scripps Research Institute, La Jolla, CA, USA<br \/>\n1988 Completed postdoctoral dissertation (habilitation, prerequisite for professorship) at the Humboldt University in Berlin<br \/>\n1987 Visiting Professor at the Second Dept. of Medicine, Teikyo University and Department of Medicine; Physical Therapy (Kazuhiko Yamamoto\u2019s Lab), University of Tokyo, Japan<br \/>\n1977 degree thesis (Dr. med.), Faculty of Medicine, Humboldt University, Berlin)<br \/>\n1976 Diploma (Dipl.-Med.), Faculty of Medicine, Humboldt University, Berlin<\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69ddfc050f6d8_1\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">Education<\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69ddfc050f6d8_1\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p>1994 Specialization in Rheumatology<br \/>\n1983 Specialization in Internal Medicine<br \/>\n1978-1983 Resident Department of Internal Medicine, Charit\u00e9 Berlin, Germany<br \/>\n1971-1976 Study of Medicine, Humboldt-University Berlin, Germany<\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69ddfc050f6d8_2\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">Professional Activities<\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69ddfc050f6d8_2\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p>Since 2014 Chair,\u00a0 Deutsche Gesellschaft f\u00fcr Lupus-Forschung<br \/>\nSince 2000 IUIS\/WHO\/AF\/CDC Committee for the Standardization of Autoantibodies in Rheumatic and Related Disease,<br \/>\nInternational Advisory Board of Modern Rheumatology,<br \/>\nThe Japan Rheumatism Association<br \/>\nSpeaker, Arbeitskreis \u201eExtrakorporale Therapieverfahren und Stammzelltherapie\u201c, DGRh<br \/>\n2002-2014 Drug Commission of the German Medical Associatio<\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69ddfc050f6d8_3\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">Society Memberships<\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69ddfc050f6d8_3\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p>The German Society for Rheumatology,<br \/>\nThe German Society for Immunology,<br \/>\nThe Henry Kunkel Society, Deutsche Gesellschaft f\u00fcr Lupus-Forschung,<br \/>\nEBMT working party \u201cautoimmune diseases\u201d,<br \/>\nRheuma-Liga Berlin e.V., Gesellschaft f\u00fcr Natur- und Heilkunde in Berlin,<br \/>\nGesellschaft zur F\u00f6rderung der Immundiagnostik e.V.,<br \/>\nFreunde und F\u00f6rderer der Charit\u00e9<\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69ddfc050f6d8_4\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">Fellowships and Awards<\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69ddfc050f6d8_4\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p>Award Wolfgang-Schulze Foundation,<br \/>\nEULAR-award of EWRR,<br \/>\nIdeenwettbewerb Deutsche Rheumastiftung,<br \/>\nHumboldt Award for Best Diploma,<br \/>\nResearch Award Charit\u00e9 Hospital<\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                      <\/div>\n        <\/div>\n          <\/div>\n  <\/section>\n\n\n\n\n  <section id=\"news\"\n           class=\"section related-news alignwide related-news--slider  toc-item\">\n    <div class=\"container container--center\">\n\n      <div class=\"related-news__wrap\">\n                  <div class=\"section__heading-container launimation slideBottom\">\n                          <h2 class=\"section__heading\">News<\/h2>\n                                  <\/div>\n        \n        \n        <div class=\"related-news__slider swiper swiper-pull-right\">\n                      <div class=\"slider__skip-links-container\">\n              <a id=\"before-slider-block_897dc2541eade9a37fc68c812ffe240d\"\n                 href=\"#after-slider-block_897dc2541eade9a37fc68c812ffe240d\"\n                 class=\"slider-skip-link\">Go to end of slider<\/a>\n            <\/div>\n          \n          <div class=\"swiper-wrapper grid graded-boxes\">\n                          <div class=\"swiper-slide\">\n                \n<article\n  id=\"post-8353\" class=\"teaser-post box box--min-height launimation slideBottom graded-box post-8353 post type-post status-publish format-standard has-post-thumbnail hentry category-publications tag-autoimmunology tag-program-area-4 tag-tobias-alexander programme-area-tax-programme-area-4 working-group-tax-autoimmunology\">\n  <div class=\"teaser-post__wrap\">\n    <div class=\"teaser-post__cats\">\n      \n<ul class=\"tag-pills tag-pills--small\" role=\"none\">\n      <li role=\"none\">\n      <span class=\"tag-pill\">\n        <span class=\"visually-hidden\">Kategorie: <\/span>\n        Publications      <\/span>\n    <\/li>\n  <\/ul>    <\/div>\n\n    <div class=\"teaser-post__body\">\n      <time class=\"date\" datetime=\"2024-09-25 10:47:00\">25.09.2024<\/time>\n      <div class=\"teaser-post__title h5\">\n        <a href=\"https:\/\/www.drfz.de\/en\/neuigkeiten\/komplette-remission-nach-behandlung-mit-krebsmedikament-bei-sle\/\" aria-describedby=\"post-8353\"\n          title=\"Gehe zum Beitrag\" rel=\"bookmark\">\n          Complete remission of SLE after treatment with cancer drug        <\/a>\n      <\/div>\n\n              <div class=\"teaser-post__excerpt ellipsis\">\n          PD Dr. med. Tobias Alexander from the Department of Rheumatology at Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin and liaison group leader at the DRFZ and Prof. Jan\u2026        <\/div>\n          <\/div>\n  <\/div>\n<\/article>              <\/div>\n                          <div class=\"swiper-slide\">\n                \n<article\n  id=\"post-13118\" class=\"teaser-post box box--min-height launimation slideBottom graded-box post-13118 post type-post status-publish format-standard has-post-thumbnail hentry category-news-en tag-autoimmunology tag-innate-immunity tag-program-area-1 tag-program-area-4\">\n  <div class=\"teaser-post__wrap\">\n    <div class=\"teaser-post__cats\">\n      \n<ul class=\"tag-pills tag-pills--small\" role=\"none\">\n      <li role=\"none\">\n      <span class=\"tag-pill\">\n        <span class=\"visually-hidden\">Kategorie: <\/span>\n        News      <\/span>\n    <\/li>\n  <\/ul>    <\/div>\n\n    <div class=\"teaser-post__body\">\n      <time class=\"date\" datetime=\"2023-11-01 10:42:00\">01.11.2023<\/time>\n      <div class=\"teaser-post__title h5\">\n        <a href=\"https:\/\/www.drfz.de\/en\/neuigkeiten\/promotionspreise-fuer-zwei-drfz-forscher-beim-sfi-dgfi-joint-meeting\/\" aria-describedby=\"post-13118\"\n          title=\"Gehe zum Beitrag\" rel=\"bookmark\">\n          Awards for two DRFZ researchers at the SFI-DGfI Joint Meeting        <\/a>\n      <\/div>\n\n              <div class=\"teaser-post__excerpt ellipsis\">\n          Two early-career researchers from the DRFZ were recognised for their outstanding doctoral work at the joint annual meeting of the German Society for Immunology (DGfI)\u2026        <\/div>\n          <\/div>\n  <\/div>\n<\/article>              <\/div>\n            \n          <\/div><!-- swiper-wrapper -->\n\n                      <div class=\"slider__pagination slider__pagination--contained\">\n              <button class=\"slider__button-prev\"><\/button>\n              <button class=\"slider__button-next\"><\/button>\n            <\/div>\n          \n                      <div class=\"slider__skip-links-container\">\n              <a id=\"after-slider-block_897dc2541eade9a37fc68c812ffe240d\"\n                 href=\"#before-slider-block_897dc2541eade9a37fc68c812ffe240d\"\n                 class=\"skip-link\">Go to beginning of slider<\/a>\n            <\/div>\n                  <\/div>\n\n                      <\/div>\n\n    <\/div><!-- container -->\n  <\/section>\n\n\n\n\n  <section id=\"top-5-publications\" class=\"section links-list  alignwide  toc-item\">\n    <div class=\"container container--center\">\n                        <h2 class=\"section__heading launimation slideBottom\">TOP 5 PUBLICATIONS<\/h2>\n        \n              \n      <div class=\"links-list__items-wrap\">\n        \n<div class=\"links-list__items links-list__items--row \">\n      <div class=\"links-list__item  launimation slideBottom\">\n      \n      <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.201948144\" target=\"_blank\" class=\"h6 links-list__item-title\">Selective depletion of plasma cells in vivo based on the specificity of their secreted antibodies<\/a>\n\n              <span class=\"links-list__item-underline\">Cheng, Q., A. Pelz, A. Taddeo, L. Khodadadi, J. Klotsche, B. F. Hoyer, T. Alexander, A. Thiel, G. R. Burmester, A. Radbruch, and F. Hiepe. 2020. Selective depletion of plasma cells in vivo based on the specificity of their secreted antibodies. Eur J Immunol 50: 284-291.<\/span>\n      \n      <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/eji.201948144\" target=\"_blank\" class=\"links-list__item-link\">\n        <span class=\"button button--arrow button--arrow-nw button--arrow-link\" ><\/span>\n      <\/a>\n    <\/div>\n      <div class=\"links-list__item  launimation slideBottom\">\n      \n      <a href=\"https:\/\/www.nature.com\/articles\/nrrheum.2011.1\" target=\"_blank\" class=\"h6 links-list__item-title\">Long-lived autoreactive plasma cells drive persistent autoimmune inflammation<\/a>\n\n              <span class=\"links-list__item-underline\">Hiepe, F., T. D\u00f6rner, A.E. Hauser, B.F. Hoyer, H. Mei, and A. Radbruch. 2011. Long-lived autoreactive plasma cells drive persistent autoimmune inflammation. Nat Rev Rheumatol 7:170-178.<\/span>\n      \n      <a href=\"https:\/\/www.nature.com\/articles\/nrrheum.2011.1\" target=\"_blank\" class=\"links-list__item-link\">\n        <span class=\"button button--arrow button--arrow-nw button--arrow-link\" ><\/span>\n      <\/a>\n    <\/div>\n      <div class=\"links-list__item  launimation slideBottom\">\n      \n      <a href=\"https:\/\/ashpublications.org\/blood\/article\/113\/1\/214\/24392\/Depletion-of-autoreactive-immunologic-memory\" target=\"_blank\" class=\"h6 links-list__item-title\">Depletion of autoreactive immunologic memory followed by autologous hematopoietic stem cell transplantation in patients with refractory SLE induces long-term remission through de novo generation of a juvenile and tolerant immune system<\/a>\n\n              <span class=\"links-list__item-underline\">Alexander, T., A. Thiel, O. Rosen, G. Massenkeil, A. Sattler, S. Kohler, H. Mei, H. Radtke, E. Gromnica-Ihle, G. R. Burmester, R. Arnold, A. Radbruch, and F. Hiepe. 2009. Depletion of autoreactive immunologic memory followed by autologous hematopoietic stem cell transplantation in patients with refractory SLE induces long-term remission through de novo generation of a juvenile and tolerant immune system. Blood 113: 214-223<\/span>\n      \n      <a href=\"https:\/\/ashpublications.org\/blood\/article\/113\/1\/214\/24392\/Depletion-of-autoreactive-immunologic-memory\" target=\"_blank\" class=\"links-list__item-link\">\n        <span class=\"button button--arrow button--arrow-nw button--arrow-link\" ><\/span>\n      <\/a>\n    <\/div>\n      <div class=\"links-list__item  launimation slideBottom\">\n      \n      <a href=\"https:\/\/rupress.org\/jem\/article\/199\/11\/1577\/39969\/Short-lived-Plasmablasts-and-Long-lived-Plasma\" target=\"_blank\" class=\"h6 links-list__item-title\">Short-lived plasmablasts and long-lived plasma cells contribute to chronic humoral autoimmunity in NZB\/W mice<\/a>\n\n              <span class=\"links-list__item-underline\">Hoyer, B. F., K. Moser, A. E. Hauser, A. Peddinghaus, C. Voigt, D. Eilat, A. Radbruch, F. Hiepe*, and R. A. Manz*. 2004. Short-lived plasmablasts and long-lived plasma cells contribute to chronic humoral autoimmunity in NZB\/W mice. The Journal of experimental medicine 199: 1577-1584. *contributed equally<\/span>\n      \n      <a href=\"https:\/\/rupress.org\/jem\/article\/199\/11\/1577\/39969\/Short-lived-Plasmablasts-and-Long-lived-Plasma\" target=\"_blank\" class=\"links-list__item-link\">\n        <span class=\"button button--arrow button--arrow-nw button--arrow-link\" ><\/span>\n      <\/a>\n    <\/div>\n      <div class=\"links-list__item  launimation slideBottom\">\n      \n      <a href=\"https:\/\/www.jci.org\/articles\/view\/2749\" target=\"_blank\" class=\"h6 links-list__item-title\">A novel epitope on the C-terminus of SmD1 is recognized by the majority of sera from patients with systemic lupus erythematosus.<\/a>\n\n              <span class=\"links-list__item-underline\">Riemekasten, G., J. Marell, G. Trebeljahr, R. Klein, G. Hausdorf, T. H\u00e4upl, J. Schneider-Mergener, G. R. Burmester, and F. Hiepe. 1998. A novel epitope on the C-terminus of SmD1 is recognized by the majority of sera from patients with systemic lupus erythematosus. J Clin Invest 102: 754-763.<\/span>\n      \n      <a href=\"https:\/\/www.jci.org\/articles\/view\/2749\" target=\"_blank\" class=\"links-list__item-link\">\n        <span class=\"button button--arrow button--arrow-nw button--arrow-link\" ><\/span>\n      <\/a>\n    <\/div>\n  <\/div>\n      <\/div>\n    <\/div>\n  <\/section>\n\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":4,"featured_media":1376,"menu_order":0,"template":"","department":[553],"function":[],"liaison":[229],"programme-area-function":[],"programme-area-tax":[],"working-group-function":[],"working-group-tax":[240],"class_list":["post-2980","head","type-head","status-publish","has-post-thumbnail","hentry","department-scientific-staff","liaison-charite-rheumatology-and-clinical-immunology","working-group-tax-autoimmunology"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Prof. Dr. med. 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