{"id":8794,"date":"2025-01-24T13:03:55","date_gmt":"2025-01-24T13:03:55","guid":{"rendered":"https:\/\/www.drfz.de\/?post_type=head&#038;p=8794"},"modified":"2025-03-27T15:02:15","modified_gmt":"2025-03-27T15:02:15","slug":"fritz-melchers","status":"publish","type":"head","link":"https:\/\/www.drfz.de\/en\/koepfe\/fritz-melchers\/","title":{"rendered":"Prof. Dr. Fritz Melchers \u2020"},"content":{"rendered":"\n  <section id=\"scientific-background\"\n           class=\"section accordion  alignwide  toc-item\"\n           data-open=\"multiple\">\n    <div class=\"container container--center container--medium\">\n              <h2 class=\"h3 section__heading launimation slideBottom\">Scientific Background<\/h2>\n      \n      \n      \n              <div id=\"panel-\"\n             class=\"accordion__category active\" role=\"tabpanel\"\n             aria-labelledby=\"tab-\">\n                    <script type=\"application\/ld+json\">\n            {\n              \"@context\": \"https:\/\/schema.org\",\n              \"@type\": \"FAQPage\",\n              \"mainEntity\": [{\"@type\": \"Question\",\"name\": \"Scientific Career\",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"Since 2017 Senior Scientist and Group Leader,\nDRFZ 2008 \u2013 2016 Max Planck Fellow\n2003 \u2013 2007 Senior Research Group Leader, Max Planck Institute for Infection Biology, Berlin\n1981 \u2013 2001 Director, Basel Institute for Immunology, Basel, Switzerland\n1970 \u2013 1980 Permanent Member, Basel Institute for Immunology, Basel, Switzerland\n1970 \u2013 1971 Visiting Scientist, Department of Genetics, Stanford University Medical School\n1970 Visiting Scientist, Weizmann Institute, Rehovot, Israel\n1970 Senior Research Assistant, Max Planck Institute for Molecular Genetics, Berlin\n1968 \u2013 1969 Postdoctoral Fellow, Max Planck Institute for Molecular Genetics, Berlin\n1965 \u2013 1967 Research Associate, Salk Institute for Biological Studies, La Jolla, CA, USA (Fulbright)\n1971 Dr. rer. nat. habil., Venia legendi, University of Freiburg i.Br., Faculty of Biology\n1964 Ph.D. (Dr. rer. nat.), University of Cologne, Germany\n1961 Dipl. chem., University of Cologne, German\"}},{\"@type\": \"Question\",\"name\": \"Boards\",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"2010 \u2013 2018 Tuberculosis Vaccine Initiative, Amsterdam\n2003 \u2013 2010 Member and Vice-President, University Council Hannover Medical School, Germany\n2002 \u2013 2014 4-Antibody GmbH, Basel, Switzerland, Co-founder\n1998 \u2013 2001 President, IUIS (International Union of Immunological Societies)rnrn1996 \u2013 2003rnMember \u201cUniversit\u00e4tsrat\u201c, University of Basel, Switzerland\n1993 \u2013 1996 Nationaler Forschungsrat der Schweiz, Bern, Switzerland\n1992 \u2013 1999 Max Delbr\u00fcck Center for Molecular Medicine, Berlin-Buch, Germany\n1986 \u2013 1996 Paul Ehrlich Foundation, Frankfurt am Main, Germany\n1986 \u2013 2001 Deutsches Rheuma-Forschungszentrum, Berlin, Germany\"}},{\"@type\": \"Question\",\"name\": \"Memberships\",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"Academia Europea\nLeopoldina\nNorwegian Academy of Science and Letters\nSwiss Academy of Medical Sciences\nAmerican Academy for Arts and Science\nAustrian Academy of Sciences\"}},{\"@type\": \"Question\",\"name\": \"Awards\",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"2018 Leibniz-Chair, Leibniz Association\n2017 Cothenius Medal, Leopoldina\n2009 M.D.h.c. Medical University Innsbruck, Austria\n2007 Novartis Prize for Basic Immunology\n2007 M.D.h.c. University of W\u00fcrzburg, Germanyrnrn\n2006 Ph.D.h.c. University of Leipzig, Germany\n2003 M.D.h.c., University of Erlangen- Nuremberg, Germany\n2002 Gaikokujin Chomei Kenkyu-shu (Eminent Scientist) Award of the Japanese Society for the Promotion of Science (JSPS) at the University of Tokyo School of Medicine\n2002 External Scientific Member, Max Planck-Institute for Infection Biology, Berlin\n2002 Emil von Behring Preis, Marburg, Germany\n2001 Honorary Professor, Medical Faculty, University of Innsbruck, Austria\n2000 San Marino Prize\n1997 Max Delbr\u00fcck Medal, MDC, Berlin, Germany\n1996 Robert-Koch Prize, Bonn, Germany\n1996 Prausnitz-Medaille, Collegium Internationale Allergologicum (CIA), Vienna\n1995 Bundesverdienstkreuz 1. Klasse der Bundesrepublik Deutschland\n1994 Ph.D.h.c., Medical College, Thomas Jefferson University, Philadelphia, USA\n1990 M.D.h.c., University of Turku, Finland\n1988 Commendatore dell Ordine di Sant\u2019 Agata, San Marino\n1978 Honorary Professor, Faculty of Biology, Heidelberg University, Germany\"}},{\"@type\": \"Question\",\"name\": \"Publications\",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"1. Kawano Y, Petkau G, Stehle C, Durek P, Heinz GA, Tanimoto K, Karasuyama H, Mashreghi MF, Romagnani C, Melchers F. Stable lines and clones of long-term proliferating normal, genetically unmodified murine common lymphoid progenitors. Blood. 2018 May 3;131(18):2026-2035.\n2. Petkau G, Kawano Y, Wolf I, Knoll M, Melchers F. MiR221 promotes precursor B-cell retention in the bone marrow by amplifying the PI3K-signaling pathway in mice. Eur J Immunol. 2018 Mar 5. doi: 10.1002\/eji.201747354.\n3. Tornack J, Kawano Y, Garbi N, H\u00e4mmerling GJ, Melchers F, Tsuneto M. Flt3 ligand-eGFP-reporter expression characterizes functionally distinct subpopulations of CD150+ long-term repopulating murine hematopoietic stem cells. Eur J Immunol. 2017 Sep;47(9):1477-1487.\n4. Wolf I, Bouquet C, Naumann F, Melchers F. Generation of precursor, immature, and mature murine B1-cell lines from c-myc\/bcl-xL-overexpressing pre-BI cells. Eur J Immunol. 2017 May;47(5):911-920. doi: 10.1002\/eji.201746937. Epub 2017 Apr 6.\n5. Tornack J, Reece ST, Bauer WM, Vogelzang A, Bandermann S, Zedler U, Stingl G, Kaufmann SH, Melchers F. Human and Mouse Hematopoietic Stem Cells Are a Depot for Dormant Mycobacterium tuberculosis. PLoS One. 2017 Jan 3;12(1):e0169119. doi: 10.1371\/journal.pone.0169119. eCollection 2017.\n6. Wolf I, Bouquet C, Melchers F. cDNA-library testing identifies transforming genes cooperating with c-myc in mouse pre-B cells. Eur J Immunol. 2016 Nov;46(11):2555-2565.\n7. Kawano Y, Petkau G, Wolf I, Tornack J, Melchers F. IL-7 and immobilized Kit-ligand stimulate serum- and stromal cell-free cultures of precursor B-cell lines and clones. Eur J Immunol. 2017 Jan;47(1):206-212. doi: 10.1002\/eji.201646677. Epub 2016 Nov 11.\n8. Kajikhina K, Melchers F, Tsuneto M. Chemokine polyreactivity of IL7R\u03b1+CSF-1R+ lympho-myeloid progenitors in the developing fetal liver. Sci Rep. 2015 Aug 3;5:12817.\n9. Funakoshi S, Shimizu T, Numata O, Ato M, Melchers F, Ohnishi K. BILL-cadherin\/cadherin-17 contributes to the survival of memory B cells. PLoS One. 2015 Jan 22;10(1):e0117566. doi: 10.1371\/journal.pone.0117566. eCollection 2015.\n10.Knoll M, Simmons S, Bouquet C, Gr\u00fcn JR, Melchers F. miR-221 redirects precursor B cells to the BM and regulates their residence. Eur J Immunol. 2013 Sep;43(9):2497-506. doi: 10.1002\/eji.201343367. Epub 2013 Jul 8\"}}]\n            }\n          <\/script>\n\n          <div class=\"accordion__content\">\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69ec7ac279c41_0\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">Scientific Career<\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69ec7ac279c41_0\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p>Since 2017 Senior Scientist and Group Leader,<br \/>\nDRFZ 2008 \u2013 2016 Max Planck Fellow<br \/>\n2003 \u2013 2007 Senior Research Group Leader, Max Planck Institute for Infection Biology, Berlin<br \/>\n1981 \u2013 2001 Director, Basel Institute for Immunology, Basel, Switzerland<br \/>\n1970 \u2013 1980 Permanent Member, Basel Institute for Immunology, Basel, Switzerland<br \/>\n1970 \u2013 1971 Visiting Scientist, Department of Genetics, Stanford University Medical School<br \/>\n1970 Visiting Scientist, Weizmann Institute, Rehovot, Israel<br \/>\n1970 Senior Research Assistant, Max Planck Institute for Molecular Genetics, Berlin<br \/>\n1968 \u2013 1969 Postdoctoral Fellow, Max Planck Institute for Molecular Genetics, Berlin<br \/>\n1965 \u2013 1967 Research Associate, Salk Institute for Biological Studies, La Jolla, CA, USA (Fulbright)<br \/>\n1971 Dr. rer. nat. habil., Venia legendi, University of Freiburg i.Br., Faculty of Biology<br \/>\n1964 Ph.D. (Dr. rer. nat.), University of Cologne, Germany<br \/>\n1961 Dipl. chem., University of Cologne, German<\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69ec7ac279c41_1\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">Boards<\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69ec7ac279c41_1\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p>2010 \u2013 2018 Tuberculosis Vaccine Initiative, Amsterdam<br \/>\n2003 \u2013 2010 Member and Vice-President, University Council Hannover Medical School, Germany<br \/>\n2002 \u2013 2014 4-Antibody GmbH, Basel, Switzerland, Co-founder<br \/>\n1998 \u2013 2001 President, IUIS (International Union of Immunological Societies)rnrn1996 \u2013 2003rnMember \u201cUniversit\u00e4tsrat\u201c, University of Basel, Switzerland<br \/>\n1993 \u2013 1996 Nationaler Forschungsrat der Schweiz, Bern, Switzerland<br \/>\n1992 \u2013 1999 Max Delbr\u00fcck Center for Molecular Medicine, Berlin-Buch, Germany<br \/>\n1986 \u2013 1996 Paul Ehrlich Foundation, Frankfurt am Main, Germany<br \/>\n1986 \u2013 2001 Deutsches Rheuma-Forschungszentrum, Berlin, Germany<\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69ec7ac279c41_2\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">Memberships<\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69ec7ac279c41_2\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p>Academia Europea<br \/>\nLeopoldina<br \/>\nNorwegian Academy of Science and Letters<br \/>\nSwiss Academy of Medical Sciences<br \/>\nAmerican Academy for Arts and Science<br \/>\nAustrian Academy of Sciences<\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69ec7ac279c41_3\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">Awards<\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69ec7ac279c41_3\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p>2018 Leibniz-Chair, Leibniz Association<br \/>\n2017 Cothenius Medal, Leopoldina<br \/>\n2009 M.D.h.c. Medical University Innsbruck, Austria<br \/>\n2007 Novartis Prize for Basic Immunology<br \/>\n2007 M.D.h.c. University of W\u00fcrzburg, Germanyrnrn<br \/>\n2006 Ph.D.h.c. University of Leipzig, Germany<br \/>\n2003 M.D.h.c., University of Erlangen- Nuremberg, Germany<br \/>\n2002 Gaikokujin Chomei Kenkyu-shu (Eminent Scientist) Award of the Japanese Society for the Promotion of Science (JSPS) at the University of Tokyo School of Medicine<br \/>\n2002 External Scientific Member, Max Planck-Institute for Infection Biology, Berlin<br \/>\n2002 Emil von Behring Preis, Marburg, Germany<br \/>\n2001 Honorary Professor, Medical Faculty, University of Innsbruck, Austria<br \/>\n2000 San Marino Prize<br \/>\n1997 Max Delbr\u00fcck Medal, MDC, Berlin, Germany<br \/>\n1996 Robert-Koch Prize, Bonn, Germany<br \/>\n1996 Prausnitz-Medaille, Collegium Internationale Allergologicum (CIA), Vienna<br \/>\n1995 Bundesverdienstkreuz 1. Klasse der Bundesrepublik Deutschland<br \/>\n1994 Ph.D.h.c., Medical College, Thomas Jefferson University, Philadelphia, USA<br \/>\n1990 M.D.h.c., University of Turku, Finland<br \/>\n1988 Commendatore dell Ordine di Sant\u2019 Agata, San Marino<br \/>\n1978 Honorary Professor, Faculty of Biology, Heidelberg University, Germany<\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69ec7ac279c41_4\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">Publications<\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69ec7ac279c41_4\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p>1. Kawano Y, Petkau G, Stehle C, Durek P, Heinz GA, Tanimoto K, Karasuyama H, Mashreghi MF, Romagnani C, Melchers F. Stable lines and clones of long-term proliferating normal, genetically unmodified murine common lymphoid progenitors. Blood. 2018 May 3;131(18):2026-2035.<\/p>\n<p>2. Petkau G, Kawano Y, Wolf I, Knoll M, Melchers F. MiR221 promotes precursor B-cell retention in the bone marrow by amplifying the PI3K-signaling pathway in mice. Eur J Immunol. 2018 Mar 5. doi: 10.1002\/eji.201747354.<\/p>\n<p>3. Tornack J, Kawano Y, Garbi N, H\u00e4mmerling GJ, Melchers F, Tsuneto M. Flt3 ligand-eGFP-reporter expression characterizes functionally distinct subpopulations of CD150+ long-term repopulating murine hematopoietic stem cells. Eur J Immunol. 2017 Sep;47(9):1477-1487.<\/p>\n<p>4. Wolf I, Bouquet C, Naumann F, Melchers F. Generation of precursor, immature, and mature murine B1-cell lines from c-myc\/bcl-xL-overexpressing pre-BI cells. Eur J Immunol. 2017 May;47(5):911-920. doi: 10.1002\/eji.201746937. Epub 2017 Apr 6.<\/p>\n<p>5. Tornack J, Reece ST, Bauer WM, Vogelzang A, Bandermann S, Zedler U, Stingl G, Kaufmann SH, Melchers F. Human and Mouse Hematopoietic Stem Cells Are a Depot for Dormant Mycobacterium tuberculosis. PLoS One. 2017 Jan 3;12(1):e0169119. doi: 10.1371\/journal.pone.0169119. eCollection 2017.<\/p>\n<p>6. Wolf I, Bouquet C, Melchers F. cDNA-library testing identifies transforming genes cooperating with c-myc in mouse pre-B cells. Eur J Immunol. 2016 Nov;46(11):2555-2565.<\/p>\n<p>7. Kawano Y, Petkau G, Wolf I, Tornack J, Melchers F. IL-7 and immobilized Kit-ligand stimulate serum- and stromal cell-free cultures of precursor B-cell lines and clones. Eur J Immunol. 2017 Jan;47(1):206-212. doi: 10.1002\/eji.201646677. Epub 2016 Nov 11.<\/p>\n<p>8. Kajikhina K, Melchers F, Tsuneto M. Chemokine polyreactivity of IL7R\u03b1+CSF-1R+ lympho-myeloid progenitors in the developing fetal liver. Sci Rep. 2015 Aug 3;5:12817.<\/p>\n<p>9. Funakoshi S, Shimizu T, Numata O, Ato M, Melchers F, Ohnishi K. BILL-cadherin\/cadherin-17 contributes to the survival of memory B cells. PLoS One. 2015 Jan 22;10(1):e0117566. doi: 10.1371\/journal.pone.0117566. eCollection 2015.<\/p>\n<p>10.Knoll M, Simmons S, Bouquet C, Gr\u00fcn JR, Melchers F. miR-221 redirects precursor B cells to the BM and regulates their residence. Eur J Immunol. 2013 Sep;43(9):2497-506. doi: 10.1002\/eji.201343367. Epub 2013 Jul 8<\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                      <\/div>\n        <\/div>\n          <\/div>\n  <\/section>\n\n\n\n\n  <section id=\"news\"\n           class=\"section related-news alignwide related-news--slider  toc-item\">\n    <div class=\"container container--center\">\n\n      <div class=\"related-news__wrap\">\n        \n        \n        <div class=\"related-news__slider swiper swiper-pull-right\">\n          \n          <div class=\"swiper-wrapper grid graded-boxes\">\n                          <div class=\"swiper-slide\">\n                \n<article\n  id=\"post-12420\" class=\"teaser-post box box--min-height launimation slideBottom graded-box post-12420 post type-post status-publish format-standard has-post-thumbnail hentry category-news-en tag-andreas-radbruch-en tag-radbruch-en\">\n  <div class=\"teaser-post__wrap\">\n    <div class=\"teaser-post__cats\">\n      \n<ul class=\"tag-pills tag-pills--small\" role=\"none\">\n      <li role=\"none\">\n      <span class=\"tag-pill\">\n        <span class=\"visually-hidden\">Kategorie: <\/span>\n        News      <\/span>\n    <\/li>\n  <\/ul>    <\/div>\n\n    <div class=\"teaser-post__body\">\n      <time class=\"date\" datetime=\"2025-02-27 12:48:18\">27.02.2025<\/time>\n      <div class=\"teaser-post__title h5\">\n        <a href=\"https:\/\/www.drfz.de\/en\/neuigkeiten\/obituary-for-fritz-melchers\/\" aria-describedby=\"post-12420\"\n          title=\"Gehe zum Beitrag\" rel=\"bookmark\">\n          Obituary for Fritz Melchers        <\/a>\n      <\/div>\n\n              <div class=\"teaser-post__excerpt ellipsis\">\n          The DRFZ mourns the loss of one of its founding fathers who passed away on 24th of February 2025. Georg Friedrich (Fritz) Melchers was born\u2026        <\/div>\n          <\/div>\n  <\/div>\n<\/article>              <\/div>\n            \n          <\/div><!-- swiper-wrapper -->\n\n          \n                  <\/div>\n\n                      <\/div>\n\n    <\/div><!-- container -->\n  <\/section>\n\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":4,"featured_media":1394,"menu_order":0,"template":"","department":[567],"function":[],"liaison":[],"programme-area-function":[],"programme-area-tax":[],"working-group-function":[],"working-group-tax":[],"class_list":["post-8794","head","type-head","status-publish","has-post-thumbnail","hentry","department-scientists-alumni"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Prof. Dr. Fritz Melchers \u2020 - DRFZ<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.drfz.de\/en\/koepfe\/fritz-melchers\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Prof. Dr. Fritz Melchers \u2020 - 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