{"id":20167,"date":"2025-11-10T16:00:20","date_gmt":"2025-11-10T16:00:20","guid":{"rendered":"https:\/\/www.drfz.de\/?p=20167"},"modified":"2025-11-10T16:11:54","modified_gmt":"2025-11-10T16:11:54","slug":"on-the-trail-of-a-mysterious-childhood-disease-the-story-of-ace-and-research-into-pims","status":"publish","type":"post","link":"https:\/\/www.drfz.de\/en\/neuigkeiten\/on-the-trail-of-a-mysterious-childhood-disease-the-story-of-ace-and-research-into-pims\/","title":{"rendered":"On the trail of a mysterious childhood disease\u2014The story of Ace and research into PIMS"},"content":{"rendered":"\n

Tilmann Kallinich and Mir-Farzin Mashreghi in Leibniz Magazine<\/strong><\/h2>\n\n\n\n

In Leibniz Magazine, Fabian Zapatka tells the story of six-year-old Ace Jaite, representing many children with Pediatric Inflammatory Multisystem Syndrome (PIMS). Ace is one of the young patients who Prof. Dr. Tilmann Kallinich from Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin and the German Rheumatology Research Center Berlin (DRFZ), a Leibniz Institute, has been treating for five years. Together with PD Dr. Mir-Farzin Mashreghi, Deputy Scientific Director at DRFZ, he has uncovered the cellular and molecular mechanisms underlying this serious disease.\u00a0<\/p>\n\n\n\n

The article describes the story of six-year-old Ace Jaite, who in early 2022 suffered severely from inflammatory shock triggered by PIMS. PIMS occurs primarily as a result of COVID-19, causing children’s immune systems to overreact and attack organs such as the heart and kidneys. After several visits to the emergency room and a deterioration in his health, Ace was admitted to the intensive care unit at Charit\u00e9, where he was diagnosed in critical condition.<\/p>\n\n\n\n

Tilmann Kallinich, Professor of Pediatric Rheumatology at Charit\u00e9, recognized early on that this could be PIMS. However, the mechanism of the disease, which dysregulates the immune system and leads to multiple organ failure, was still largely unknown. Mir-Farzin Mashreghi works closely with Tilmann Kallinich and helped to identify specific markers that are characteristic of PIMS patients through cell analyses of the young patient. In particular, elevated TGF\u03b2 levels were identified as an indicator of the disease.<\/p>\n\n\n\n

PIMS is triggered by a dysregulated immune response in which the immune system attacks the body’s own organs. In severe cases, such as Ace’s, the disease leads to acute organ failure, which could only be treated with intensive medical care and early diagnosis. Thanks to the expertise of Kallinich and Mashreghi and targeted therapy, Ace was ultimately saved. Ace Jaite has now made a full recovery and has no long-term injuries from the disease.<\/p>\n\n\n\n

\n
Leibniz article<\/a><\/div>\n<\/div>\n\n\n\n

Key role of TGF\u00df and EBV in PIMS<\/strong><\/h3>\n\n\n\n

In 2025, the underlying mechanism of the disease was published by Kallinich and Mashreghi in the journal Nature, representing an important scientific breakthrough. The authors discovered that the messenger substance TGF\u03b2 plays a crucial role in the dysregulation of the immune system. At the same time, the Epstein-Barr virus (EBV) is reactivated, leading to an extreme overreaction of the immune system and causing organ damage<\/p>\n\n\n\n

\n
News about Nature publication<\/a><\/div>\n<\/div>\n\n\n\n
\n
\n
\n

Projektleiter<\/h2>\n \n <\/div>\n \n
\n \n\n
\n \"\" <\/div>\n
\n

Dr. Mir-Farzin Mashreghi<\/h2>\n
\n

\n Leader: Programme Area 3, PA 3 \u2013 Systems Rheumatology <\/p>\n

\n Group leader: Therapeutic Gene Regulation <\/p>\n <\/div>\n <\/div>\n\n

\n

mashreghi@drfz.de<\/a><\/p>\n <\/div>\n Dr. Mir-Farzin Mashreghi<\/span><\/a>\n<\/article>\n\n

\n \"\" <\/div>\n
\n

Prof. Dr. med. Tilmann Kallinich<\/h2>\n
\n

\n Programme Area 3, PA 3 \u2013 Systems Rheumatology <\/p>\n

\n Group leader: Chronic inflammation in childhood <\/p>\n Liaison working group with Charit\u00e9 – Dep. of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine<\/p>\n <\/div>\n <\/div>\n\n

\n

tilmann.kallinich@charite.de<\/a><\/p>\n <\/div>\n Prof. Dr. med. Tilmann Kallinich<\/span><\/a>\n<\/article> <\/div>\n <\/div>\n <\/section>\n\n\n\n

Foto: Fabian Zapatka<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

Tilmann Kallinich and Mir-Farzin Mashreghi in Leibniz Magazine In Leibniz Magazine, Fabian Zapatka tells the story of six-year-old Ace Jaite, representing many children with Pediatric\u2026<\/p>\n","protected":false},"author":4,"featured_media":20185,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[288,292],"tags":[421,468,475,496,426],"programme-area-tax":[],"working-group-tax":[],"class_list":["post-20167","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-for-patients","category-news-en","tag-chronic-inflammatory-diseases-of-childhood-adolescence","tag-kallinich","tag-mashreghi-en","tag-program-area-3","tag-therapeutic-gene-regulation"],"acf":[],"yoast_head":"\nOn the trail of a mysterious childhood disease\u2014The story of Ace and research into PIMS - DRFZ<\/title>\n<meta name=\"description\" content=\"An article about PMS and Tilmann Kallinich and Mir-Farzin Mashreghi from DRFZ and Charit\u00e9 is published in Leibniz Magazine\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.drfz.de\/en\/neuigkeiten\/on-the-trail-of-a-mysterious-childhood-disease-the-story-of-ace-and-research-into-pims\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"On the trail of a mysterious childhood disease\u2014The story of Ace and research into PIMS - DRFZ\" \/>\n<meta property=\"og:description\" content=\"An article about PMS and Tilmann Kallinich and Mir-Farzin Mashreghi from DRFZ and Charit\u00e9 is published in Leibniz Magazine\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.drfz.de\/en\/neuigkeiten\/on-the-trail-of-a-mysterious-childhood-disease-the-story-of-ace-and-research-into-pims\/\" \/>\n<meta property=\"og:site_name\" content=\"DRFZ\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/drfz.de\/\" \/>\n<meta property=\"article:published_time\" content=\"2025-11-10T16:00:20+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-11-10T16:11:54+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/10\/25_10_27_PIMS-Artikel-Fabian-Zapatka_Beitragsbild.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1280\" \/>\n\t<meta property=\"og:image:height\" content=\"720\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Ute Hoffmann\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@DRFZ_Berlin\" \/>\n<meta name=\"twitter:site\" content=\"@DRFZ_Berlin\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Ute Hoffmann\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/neuigkeiten\\\/on-the-trail-of-a-mysterious-childhood-disease-the-story-of-ace-and-research-into-pims\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/neuigkeiten\\\/on-the-trail-of-a-mysterious-childhood-disease-the-story-of-ace-and-research-into-pims\\\/\"},\"author\":{\"name\":\"Ute Hoffmann\",\"@id\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/#\\\/schema\\\/person\\\/a86dc60d63c6fa52cb3ee62f12c72737\"},\"headline\":\"On the trail of a mysterious childhood disease\u2014The story of Ace and research into PIMS\",\"datePublished\":\"2025-11-10T16:00:20+00:00\",\"dateModified\":\"2025-11-10T16:11:54+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/neuigkeiten\\\/on-the-trail-of-a-mysterious-childhood-disease-the-story-of-ace-and-research-into-pims\\\/\"},\"wordCount\":409,\"publisher\":{\"@id\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/neuigkeiten\\\/on-the-trail-of-a-mysterious-childhood-disease-the-story-of-ace-and-research-into-pims\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.drfz.de\\\/wp-content\\\/uploads\\\/2025\\\/10\\\/25_10_27_PIMS-Artikel-Fabian-Zapatka_Beitragsbild.jpg\",\"keywords\":[\"Chronic Inflammatory Diseases of Childhood & Adolescence\",\"Kallinich\",\"Mashreghi\",\"Program area 3\",\"Therapeutic Gene Regulation\"],\"articleSection\":[\"For patients\",\"News\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/neuigkeiten\\\/on-the-trail-of-a-mysterious-childhood-disease-the-story-of-ace-and-research-into-pims\\\/\",\"url\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/neuigkeiten\\\/on-the-trail-of-a-mysterious-childhood-disease-the-story-of-ace-and-research-into-pims\\\/\",\"name\":\"On the trail of a mysterious childhood disease\u2014The story of Ace and research into PIMS - DRFZ\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/neuigkeiten\\\/on-the-trail-of-a-mysterious-childhood-disease-the-story-of-ace-and-research-into-pims\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/neuigkeiten\\\/on-the-trail-of-a-mysterious-childhood-disease-the-story-of-ace-and-research-into-pims\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.drfz.de\\\/wp-content\\\/uploads\\\/2025\\\/10\\\/25_10_27_PIMS-Artikel-Fabian-Zapatka_Beitragsbild.jpg\",\"datePublished\":\"2025-11-10T16:00:20+00:00\",\"dateModified\":\"2025-11-10T16:11:54+00:00\",\"description\":\"An article about PMS and Tilmann Kallinich and Mir-Farzin Mashreghi from DRFZ and Charit\u00e9 is published in Leibniz Magazine\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/neuigkeiten\\\/on-the-trail-of-a-mysterious-childhood-disease-the-story-of-ace-and-research-into-pims\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.drfz.de\\\/en\\\/neuigkeiten\\\/on-the-trail-of-a-mysterious-childhood-disease-the-story-of-ace-and-research-into-pims\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/neuigkeiten\\\/on-the-trail-of-a-mysterious-childhood-disease-the-story-of-ace-and-research-into-pims\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.drfz.de\\\/wp-content\\\/uploads\\\/2025\\\/10\\\/25_10_27_PIMS-Artikel-Fabian-Zapatka_Beitragsbild.jpg\",\"contentUrl\":\"https:\\\/\\\/www.drfz.de\\\/wp-content\\\/uploads\\\/2025\\\/10\\\/25_10_27_PIMS-Artikel-Fabian-Zapatka_Beitragsbild.jpg\",\"width\":1280,\"height\":720,\"caption\":\"Familie mit Tilmann Kallinich\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/neuigkeiten\\\/on-the-trail-of-a-mysterious-childhood-disease-the-story-of-ace-and-research-into-pims\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"News\",\"item\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/news\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"On the trail of a mysterious childhood disease\u2014The story of Ace and research into PIMS\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/\",\"name\":\"DRFZ\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/#organization\",\"name\":\"Deutsches Rheuma-Forschungszentrum\",\"url\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.drfz.de\\\/wp-content\\\/uploads\\\/2024\\\/10\\\/drfz-footer-logo.svg\",\"contentUrl\":\"https:\\\/\\\/www.drfz.de\\\/wp-content\\\/uploads\\\/2024\\\/10\\\/drfz-footer-logo.svg\",\"width\":1,\"height\":1,\"caption\":\"Deutsches Rheuma-Forschungszentrum\"},\"image\":{\"@id\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/drfz.de\\\/\",\"https:\\\/\\\/x.com\\\/DRFZ_Berlin\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/deutsches-rheuma-forschungszentrum-berlin\",\"https:\\\/\\\/www.youtube.com\\\/channel\\\/UCf8nDuqpkWwcmCWmfSTkE3w\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/#\\\/schema\\\/person\\\/a86dc60d63c6fa52cb3ee62f12c72737\",\"name\":\"Ute Hoffmann\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/08c654ead40d6cafc50e4ed4fbf2fe4a8a979f96141a813138eec621e1d2879f?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/08c654ead40d6cafc50e4ed4fbf2fe4a8a979f96141a813138eec621e1d2879f?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/08c654ead40d6cafc50e4ed4fbf2fe4a8a979f96141a813138eec621e1d2879f?s=96&d=mm&r=g\",\"caption\":\"Ute Hoffmann\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"On the trail of a mysterious childhood disease\u2014The story of Ace and research into PIMS - DRFZ","description":"An article about PMS and Tilmann Kallinich and Mir-Farzin Mashreghi from DRFZ and Charit\u00e9 is published in Leibniz Magazine","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.drfz.de\/en\/neuigkeiten\/on-the-trail-of-a-mysterious-childhood-disease-the-story-of-ace-and-research-into-pims\/","og_locale":"en_US","og_type":"article","og_title":"On the trail of a mysterious childhood disease\u2014The story of Ace and research into PIMS - DRFZ","og_description":"An article about PMS and Tilmann Kallinich and Mir-Farzin Mashreghi from DRFZ and Charit\u00e9 is published in Leibniz Magazine","og_url":"https:\/\/www.drfz.de\/en\/neuigkeiten\/on-the-trail-of-a-mysterious-childhood-disease-the-story-of-ace-and-research-into-pims\/","og_site_name":"DRFZ","article_publisher":"https:\/\/www.facebook.com\/drfz.de\/","article_published_time":"2025-11-10T16:00:20+00:00","article_modified_time":"2025-11-10T16:11:54+00:00","og_image":[{"width":1280,"height":720,"url":"https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/10\/25_10_27_PIMS-Artikel-Fabian-Zapatka_Beitragsbild.jpg","type":"image\/jpeg"}],"author":"Ute Hoffmann","twitter_card":"summary_large_image","twitter_creator":"@DRFZ_Berlin","twitter_site":"@DRFZ_Berlin","twitter_misc":{"Written by":"Ute Hoffmann","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.drfz.de\/en\/neuigkeiten\/on-the-trail-of-a-mysterious-childhood-disease-the-story-of-ace-and-research-into-pims\/#article","isPartOf":{"@id":"https:\/\/www.drfz.de\/en\/neuigkeiten\/on-the-trail-of-a-mysterious-childhood-disease-the-story-of-ace-and-research-into-pims\/"},"author":{"name":"Ute Hoffmann","@id":"https:\/\/www.drfz.de\/en\/#\/schema\/person\/a86dc60d63c6fa52cb3ee62f12c72737"},"headline":"On the trail of a mysterious childhood disease\u2014The story of Ace and research into PIMS","datePublished":"2025-11-10T16:00:20+00:00","dateModified":"2025-11-10T16:11:54+00:00","mainEntityOfPage":{"@id":"https:\/\/www.drfz.de\/en\/neuigkeiten\/on-the-trail-of-a-mysterious-childhood-disease-the-story-of-ace-and-research-into-pims\/"},"wordCount":409,"publisher":{"@id":"https:\/\/www.drfz.de\/en\/#organization"},"image":{"@id":"https:\/\/www.drfz.de\/en\/neuigkeiten\/on-the-trail-of-a-mysterious-childhood-disease-the-story-of-ace-and-research-into-pims\/#primaryimage"},"thumbnailUrl":"https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/10\/25_10_27_PIMS-Artikel-Fabian-Zapatka_Beitragsbild.jpg","keywords":["Chronic Inflammatory Diseases of Childhood & Adolescence","Kallinich","Mashreghi","Program area 3","Therapeutic Gene Regulation"],"articleSection":["For patients","News"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.drfz.de\/en\/neuigkeiten\/on-the-trail-of-a-mysterious-childhood-disease-the-story-of-ace-and-research-into-pims\/","url":"https:\/\/www.drfz.de\/en\/neuigkeiten\/on-the-trail-of-a-mysterious-childhood-disease-the-story-of-ace-and-research-into-pims\/","name":"On the trail of a mysterious childhood disease\u2014The story of Ace and research into PIMS - DRFZ","isPartOf":{"@id":"https:\/\/www.drfz.de\/en\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.drfz.de\/en\/neuigkeiten\/on-the-trail-of-a-mysterious-childhood-disease-the-story-of-ace-and-research-into-pims\/#primaryimage"},"image":{"@id":"https:\/\/www.drfz.de\/en\/neuigkeiten\/on-the-trail-of-a-mysterious-childhood-disease-the-story-of-ace-and-research-into-pims\/#primaryimage"},"thumbnailUrl":"https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/10\/25_10_27_PIMS-Artikel-Fabian-Zapatka_Beitragsbild.jpg","datePublished":"2025-11-10T16:00:20+00:00","dateModified":"2025-11-10T16:11:54+00:00","description":"An article about PMS and Tilmann Kallinich and Mir-Farzin Mashreghi from DRFZ and Charit\u00e9 is published in Leibniz Magazine","breadcrumb":{"@id":"https:\/\/www.drfz.de\/en\/neuigkeiten\/on-the-trail-of-a-mysterious-childhood-disease-the-story-of-ace-and-research-into-pims\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.drfz.de\/en\/neuigkeiten\/on-the-trail-of-a-mysterious-childhood-disease-the-story-of-ace-and-research-into-pims\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.drfz.de\/en\/neuigkeiten\/on-the-trail-of-a-mysterious-childhood-disease-the-story-of-ace-and-research-into-pims\/#primaryimage","url":"https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/10\/25_10_27_PIMS-Artikel-Fabian-Zapatka_Beitragsbild.jpg","contentUrl":"https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/10\/25_10_27_PIMS-Artikel-Fabian-Zapatka_Beitragsbild.jpg","width":1280,"height":720,"caption":"Familie mit Tilmann Kallinich"},{"@type":"BreadcrumbList","@id":"https:\/\/www.drfz.de\/en\/neuigkeiten\/on-the-trail-of-a-mysterious-childhood-disease-the-story-of-ace-and-research-into-pims\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.drfz.de\/en\/"},{"@type":"ListItem","position":2,"name":"News","item":"https:\/\/www.drfz.de\/en\/news\/"},{"@type":"ListItem","position":3,"name":"On the trail of a mysterious childhood disease\u2014The story of Ace and research into PIMS"}]},{"@type":"WebSite","@id":"https:\/\/www.drfz.de\/en\/#website","url":"https:\/\/www.drfz.de\/en\/","name":"DRFZ","description":"","publisher":{"@id":"https:\/\/www.drfz.de\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.drfz.de\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.drfz.de\/en\/#organization","name":"Deutsches Rheuma-Forschungszentrum","url":"https:\/\/www.drfz.de\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.drfz.de\/en\/#\/schema\/logo\/image\/","url":"https:\/\/www.drfz.de\/wp-content\/uploads\/2024\/10\/drfz-footer-logo.svg","contentUrl":"https:\/\/www.drfz.de\/wp-content\/uploads\/2024\/10\/drfz-footer-logo.svg","width":1,"height":1,"caption":"Deutsches Rheuma-Forschungszentrum"},"image":{"@id":"https:\/\/www.drfz.de\/en\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/drfz.de\/","https:\/\/x.com\/DRFZ_Berlin","https:\/\/www.linkedin.com\/company\/deutsches-rheuma-forschungszentrum-berlin","https:\/\/www.youtube.com\/channel\/UCf8nDuqpkWwcmCWmfSTkE3w"]},{"@type":"Person","@id":"https:\/\/www.drfz.de\/en\/#\/schema\/person\/a86dc60d63c6fa52cb3ee62f12c72737","name":"Ute Hoffmann","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/08c654ead40d6cafc50e4ed4fbf2fe4a8a979f96141a813138eec621e1d2879f?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/08c654ead40d6cafc50e4ed4fbf2fe4a8a979f96141a813138eec621e1d2879f?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/08c654ead40d6cafc50e4ed4fbf2fe4a8a979f96141a813138eec621e1d2879f?s=96&d=mm&r=g","caption":"Ute Hoffmann"}}]}},"_links":{"self":[{"href":"https:\/\/www.drfz.de\/en\/wp-json\/wp\/v2\/posts\/20167","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.drfz.de\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.drfz.de\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.drfz.de\/en\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.drfz.de\/en\/wp-json\/wp\/v2\/comments?post=20167"}],"version-history":[{"count":4,"href":"https:\/\/www.drfz.de\/en\/wp-json\/wp\/v2\/posts\/20167\/revisions"}],"predecessor-version":[{"id":20189,"href":"https:\/\/www.drfz.de\/en\/wp-json\/wp\/v2\/posts\/20167\/revisions\/20189"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.drfz.de\/en\/wp-json\/wp\/v2\/media\/20185"}],"wp:attachment":[{"href":"https:\/\/www.drfz.de\/en\/wp-json\/wp\/v2\/media?parent=20167"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.drfz.de\/en\/wp-json\/wp\/v2\/categories?post=20167"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.drfz.de\/en\/wp-json\/wp\/v2\/tags?post=20167"},{"taxonomy":"programme-area-tax","embeddable":true,"href":"https:\/\/www.drfz.de\/en\/wp-json\/wp\/v2\/programme-area-tax?post=20167"},{"taxonomy":"working-group-tax","embeddable":true,"href":"https:\/\/www.drfz.de\/en\/wp-json\/wp\/v2\/working-group-tax?post=20167"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}