{"id":21265,"date":"2026-02-19T08:45:09","date_gmt":"2026-02-19T08:45:09","guid":{"rendered":"https:\/\/www.drfz.de\/?p=21265"},"modified":"2026-02-20T11:46:01","modified_gmt":"2026-02-20T11:46:01","slug":"fatigue-affects-many-patients-with-rheumatic-disease","status":"publish","type":"post","link":"https:\/\/www.drfz.de\/en\/neuigkeiten\/fatigue-affects-many-patients-with-rheumatic-disease\/","title":{"rendered":"Fatigue affects many patients with rheumatic disease"},"content":{"rendered":"\n<h2 class=\"wp-block-heading alignwide toc-item\" id=\"despite-improved-inflammation-control-50-of-patients-with-rheumatic-disease-suffer-from-persistent-exhaustion-or-fatigue\"><strong>Despite improved inflammation control<\/strong> <strong>50 % of patients with rheumatic disease suffer from persistent exhaustion or fatigue<\/strong><\/h2>\n\n\n\n<p class=\"alignwide has-text-align-wide wp-block-paragraph\">Many people with inflammatory rheumatic diseases suffer from severe, persistent exhaustion or fatigue. Despite significant advances in controlling inflammatory activity, fatigue remains a common and clinically relevant symptom: approximately 55\u201367% of patients are affected, with up to 26% experiencing severe forms. Scientist Katja Thiele from the Health Services Research Group led by Dr Johanna Callhoff at the German Rheumatology Research Center (DRFZ) published these findings together with colleagues and rheumatologists in February 2026 in the international journal <em>Seminars in Arthritis and Rheumatism<\/em>.<\/p>\n\n\n\n<p class=\"alignwide has-text-align-wide wp-block-paragraph\">Annual data from nearly 10,000 patients from German National Database (NDB) was evaluated for the analysis. Katja Thiele was able to show that more than half of those affected by various inflammatory rheumatic diseases \u2013 from rheumatoid arthritis and spondyloarthritis to collagenoses and vasculitides \u2013 report moderate to severe fatigue. Depending on the diagnosis, 47\u201361% of women and 35\u201352% of men were affected. The trend analysis of fatigue data from 2007 to 2023 also showed that the average fatigue burden remained unchanged overall, despite significant improvements in inflammation-related markers and increasing workforce participation.<\/p>\n\n\n\n<p class=\"alignwide has-text-align-wide wp-block-paragraph\">The trajectory analysis over three consecutive years showed that while 19% of patients had improved fatigue, 23% had persistently high fatigue, 24% had worsening fatigue, and 35% reported persistently low fatigue. Furthermore, emotional well-being, physical functioning, coping strategies, and sleep quality were more strongly associated with the course of fatigue than inflammatory laboratory parameters.<\/p>\n\n\n\n<p class=\"alignwide has-text-align-wide wp-block-paragraph\">&#8220;The progression of fatigue reflects the complex interplay of clinical and psychosocial factors,&#8221; says Katja Thiele, summarising the relevance of her findings. &#8220;Treatment should include multidimensional interventions that go beyond traditional inflammation control to also address emotional well-being, physical functioning and social support.&#8221;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n  <section id=\"original-publication\" class=\"section links-list  alignwide  toc-item\">\n    <div class=\"container container--center\">\n                        <h2 class=\"section__heading launimation slideBottom\">Original publication<\/h2>\n        \n              \n      <div class=\"links-list__items-wrap\">\n        \n<div class=\"links-list__items links-list__items--row \">\n      <div class=\"links-list__item  launimation slideBottom\">\n      \n      <a href=\"https:\/\/pdf.sciencedirectassets.com\/272541\/1-s2.0-S0049017225X0007X\/1-s2.0-S0049017225002665\/main.pdf?X-Amz-Security-Token=IQoJb3JpZ2luX2VjELD%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FwEaCXVzLWVhc3QtMSJHMEUCIQDSnxJJv%2FiRJNvkQQLTdM1NTb9VOzJ%2Fjs%2BmcnQMnJcO3wIgNA%2B8%2BFVNsYMra4bT6UoPmIktNgo%2B1Jv2XOovDOHaGW4qswUIeBAFGgwwNTkwMDM1NDY4NjUiDJSF7jP1vOxASSJS%2FyqQBco0M892oXPwomoapWjtKIJt4vuTIHaFd0azORwiS89uiPM7bSvBKSPX%2FWb%2F2tvjEGx9Ez16jB5nN6fOZAiylmDsFsE3JT%2BrfyC78L1io%2FXkoTDbQ2%2Fp3aJcJquxWkweOe3NDaR4e%2F8wjovwFwNrdYhvNP1oyy2TypwjwpAlGX%2FRWt7YybqkpUJeVl1vL9x1HEawuHZyzjpcVGh0f9ri8omBuBx8EffMLQPLA8sUYHwXDM%2F8jBpNGO%2BQZ%2BiVQ4FHtyb0po8qFtFvcZDyP0Q9H3mwtlaCiqbBhsNIbvmWafaJgYaAgZTZfoUG1RxQcvKeWvypRdTL%2FnM7zQE%2FQZtYIRZLt7k00kDQWBijnMOuZfZMjLQpou6h%2BzgWqTAlR9pju16GE56Z0pc5iuOSJ6Kk9MkRUSquj8hcjzlNRVpIctDw4%2BdXTv35pCnggRIO9PNFe7EhjogVe5bQwqtyIX43dPqByPWqwM%2F6%2Fi5xUAOeiGkyVo%2BDcYNMlRUjvp4HDYrPi6L%2BKEBp8fVFd%2F%2FF3RV0qfMOGgFsVeryXA%2FmcBqGtCpxoA8IZn8LGpGFeD%2BroouftjO1ffQ9tAmKga741C8avA5tYASzaTdBoAhSg8XU%2FrlOqNxB3e1pQeiCHEPi7PeDzv1KtqTzJmARvph0s18yNIoorCTNbkiBWwUzvUMYG9XeFkyT2%2B%2BDf0%2BFcWmsq%2BAdu88aYmV3MqsZJ3OJfzS94L%2B%2Fk4e85F8PwvefgpVR9HeOG5kKv6j%2BUiK3psc7w2Z8jlhk3ap1fGt2g%2BVEOPZWotbAyD2F0x%2BTEObhcOBDxoW9PvBSt9mCG0X1gtqZ9FSZ%2BITVlVY%2Fg6VH9%2Bc%2B2RucmraMfFAeApOj3w%2Ft%2B4DQzUm9MPny2swGOrEBKFIU4xdf6anhriIgt5E1ZEZuNbzOaO6PO%2FDlCyhw0V2Pb9%2B%2FYBUgI9B9Otc25xBGv3SOBsXyTop9GwKszl55PsNrPrAoX%2FhMa0sbxnAfAmccgNQ6Ry0HKhcO8HiodW7HdT768JcFDBojdjrzV%2BBocAPQySonV64JuGnYTx8cIkIPdBdCpoPBZk7wHgFsPrT%2FyAly1whG9e7ZKz8AjSTQI6oFnOjQ%2FLVwjqUtos0lLiMC&#038;X-Amz-Algorithm=AWS4-HMAC-SHA256&#038;X-Amz-Date=20260219T082627Z&#038;X-Amz-SignedHeaders=host&#038;X-Amz-Expires=300&#038;X-Amz-Credential=ASIAQ3PHCVTY5KOHFMV4%2F20260219%2Fus-east-1%2Fs3%2Faws4_request&#038;X-Amz-Signature=873c337951c1d6fc799bb7bd361620139e0476880c890f13828b674fe0968d14&#038;hash=1a5cefb739836d79412717c1a4fee0029dbdcaf2a7b836f54b9d3836b7ee47f0&#038;host=68042c943591013ac2b2430a89b270f6af2c76d8dfd086a07176afe7c76c2c61&#038;pii=S0049017225002665&#038;tid=spdf-c57f1767-c616-45a6-bdab-af371d308a58&#038;sid=a7c213936225c6463e2860c501127ed43e35gxrqb&#038;type=client&#038;tsoh=d3d3LnNjaWVuY2VkaXJlY3QuY29t&#038;rh=d3d3LnNjaWVuY2VkaXJlY3QuY29t&#038;ua=06005e065756575651&#038;rr=9d04611ead6e339b&#038;cc=de\" target=\"_self\" class=\"h6 links-list__item-title\">Trends in fatigue in inflammatory rheumatic diseases: Annual data and trajectory analysis of the German National Database 2007-2023<\/a>\n\n              <span class=\"links-list__item-underline\">Thiele K, Albrecht K, Veltri C, Karberg K, K\u00f6hler B, Callhoff J, Richter JG. Trends in fatigue in inflammatory rheumatic diseases: Annual data and trajectory analysis of the German National Database 2007-2023. Semin Arthritis Rheum. 2026 Feb;76:152895. doi: 10.1016\/j.semarthrit.2025.152895. Epub 2025 Dec 11. PMID: 41412093.<\/span>\n      \n      <a 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target=\"_self\" class=\"links-list__item-link\">\n        <span class=\"button button--arrow button--arrow-nw button--arrow-link\" ><\/span>\n      <\/a>\n    <\/div>\n  <\/div>\n      <\/div>\n    <\/div>\n  <\/section>\n\n\n\n\n  <section id=\"scientists-involved\"    class=\"section grid-heads alignwide toc-item\">\n    <div class=\"container container--center\">\n              <div class=\"grid-heads__header\">\n                      <h2 class=\"section__heading launimation slideBottom\">Scientists involved<\/h2>\n          \n                  <\/div>\n      \n              <div class=\"grid-heads__items grid grid--4\">\n          \n<article\n  id=\"post-8787\" class=\"teaser-head launimation slideBottom  post-8787 head type-head status-publish has-post-thumbnail hentry department-pa-2-epidemiology-and-health-services-research function-group-leader programme-area-tax-programme-area-2 working-group-function-group-leader working-group-tax-health-services-research\">\n  <div class=\"teaser-head__image\">\n          <img decoding=\"async\" loading=\"lazy\" sizes=\"auto, 520px\" src=\"https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/02\/Callhoff-1-150x98.jpg\" data-src=\"https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/02\/Callhoff-1-1024x666.jpg\" data-srcset=\"https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/02\/Callhoff-1-1920x1248.jpg 1920w, https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/02\/Callhoff-1-1600x1040.jpg 1600w, https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/02\/Callhoff-1-1366x888.jpg 1366w, https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/02\/Callhoff-1-1024x666.jpg 1024w, https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/02\/Callhoff-1-768x499.jpg 768w, https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/02\/Callhoff-1-550x358.jpg 550w\" class=\"image image--landscape\" alt=\"\"  width=\"1024\"  height=\"666\">      <\/div>\n  <div class=\"teaser-head__header\">\n    <!--    -->    <!--      -->    <!--    -->    <h2 class=\"h6 teaser-head__title launimation slideBottom\">Dr. Johanna Callhoff<\/h2>\n          <div class=\"teaser-head__role\">\n                  <p class=\"text-label function\">Group leader<\/p>\n                          <p class=\"text-label programme_area_function programme_area department\">\n            Programme Area 2, PA 2 \u2013 Epidemiology and Health Services Research          <\/p>\n                          <p class=\"text-label working_group_function working_group\">\n            Group leader: Health Services Research          <\/p>\n                      <\/div>\n      <\/div>\n\n      <div class=\"teaser-head__contact\">\n              <p class=\"text-label\"><a href=\"mailto:johanna.callhoff@drfz.de\"\">johanna.callhoff@drfz.de<\/a><\/p>\n          <\/div>\n    <a href=\"https:\/\/www.drfz.de\/en\/koepfe\/johanna-callhoff\/\"\n    aria-describedby=\"post-8787\"\n    title=\"Gehe zum Beitrag\" rel=\"bookmark\"\n    class=\"teaser-head__link button button--small button--arrow button--arrow-link\"><span\n      class=\"visually-hidden\">Dr. Johanna Callhoff<\/span><\/a>\n<\/article>\n<article\n  id=\"post-15618\" class=\"teaser-head launimation slideBottom  post-15618 head type-head status-publish has-post-thumbnail hentry department-scientists-en programme-area-tax-programme-area-2 working-group-tax-health-services-research\">\n  <div class=\"teaser-head__image\">\n          <img decoding=\"async\" loading=\"lazy\" sizes=\"auto, 520px\" src=\"https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/04\/Albrecht-2022-150x100.jpg\" data-src=\"https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/04\/Albrecht-2022.jpg\" data-srcset=\"https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/04\/Albrecht-2022.jpg 1920w, https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/04\/Albrecht-2022.jpg 1600w, https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/04\/Albrecht-2022.jpg 1366w, https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/04\/Albrecht-2022.jpg 1024w, https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/04\/Albrecht-2022-768x512.jpg 768w, https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/04\/Albrecht-2022-550x367.jpg 550w\" class=\"image image--landscape\" alt=\"Dr. Katinka Albrecht\"  width=\"1024\"  height=\"683\">      <\/div>\n  <div class=\"teaser-head__header\">\n    <!--    -->    <!--      -->    <!--    -->    <h2 class=\"h6 teaser-head__title launimation slideBottom\">Dr. med. Katinka Albrecht<\/h2>\n          <div class=\"teaser-head__role\">\n                          <p class=\"text-label programme_area_function programme_area department\">\n            Programme Area 2, Scientists          <\/p>\n                          <p class=\"text-label working_group_function working_group\">\n            Health Services Research          <\/p>\n                      <\/div>\n      <\/div>\n\n      <div class=\"teaser-head__contact\">\n              <p class=\"text-label\"><a href=\"mailto:albrecht@drfz.de\"\">albrecht@drfz.de<\/a><\/p>\n          <\/div>\n    <a href=\"https:\/\/www.drfz.de\/en\/koepfe\/dr-med-katinka-albrecht\/\"\n    aria-describedby=\"post-15618\"\n    title=\"Gehe zum Beitrag\" rel=\"bookmark\"\n    class=\"teaser-head__link button button--small button--arrow button--arrow-link\"><span\n      class=\"visually-hidden\">Dr. med. Katinka Albrecht<\/span><\/a>\n<\/article>        <\/div>\n          <\/div>\n  <\/section>\n\n\n\n<p class=\"alignwide has-text-align-wide wp-block-paragraph\">Grafik: Adobe Stock (332624215)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Despite improved inflammation control 50 % of patients with rheumatic disease suffer from persistent exhaustion or fatigue Many people with inflammatory rheumatic diseases suffer from\u2026<\/p>\n","protected":false},"author":4,"featured_media":21264,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[288,291],"tags":[460,389,493],"programme-area-tax":[180],"working-group-tax":[259],"class_list":["post-21265","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-for-patients","category-publications","tag-callhoff","tag-health-services-research","tag-program-area-2","programme-area-tax-programme-area-2","working-group-tax-health-services-research"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Fatigue affects many patients with rheumatic disease - DRFZ<\/title>\n<meta name=\"description\" content=\"Johanna Callhoff and Katinka Albrecht from DRFZ found out that 50 % of patients with rheumatic disease have persistent 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