{"id":24447,"date":"2026-08-27T12:01:11","date_gmt":"2026-08-27T12:01:11","guid":{"rendered":"https:\/\/www.drfz.de\/?p=24447"},"modified":"2026-08-27T12:01:11","modified_gmt":"2026-08-27T12:01:11","slug":"car-t-cell-therapy-shows-promise-for-severe-rheumatoid-arthritis","status":"publish","type":"post","link":"https:\/\/www.drfz.de\/en\/neuigkeiten\/car-t-cell-therapy-shows-promise-for-severe-rheumatoid-arthritis\/","title":{"rendered":"CAR-T Cell Therapy Shows Promise for Severe Rheumatoid Arthritis"},"content":{"rendered":"\n<h2 class=\"wp-block-heading alignwide toc-item\" id=\"car-t-cells-slow-down-severe-ra\">CAR-T Cells Slow Down Severe RA<\/h2>\n\n\n\n<p class=\"alignwide wp-block-paragraph\">CAR-T cells are body\u2019s own immune cells that have been genetically modified in the laboratory. This enables them to specifically recognize and eliminate certain B cells\u2014immune cells that may contribute to inflammation in rheumatoid arthritis (RA).<\/p>\n\n\n\n<p class=\"alignwide wp-block-paragraph\">In a world-first clinical trial conducted by the team of Prof. Dr. Gerhard Kr\u00f6nke, head of Clinic for Rheumatology at Charit\u00e9 \u2013 Universit\u00e4smedizin Berlin and liaison group leader at DRFZ, six patients with severe rheumatoid arthritis that was especially difficult to control were treated with CAR-T-Cell therapy. Disease activity decreased significantly in all of them; three patients remained in sustained remission without rheumatoid arthritis medication through the end of the follow-up period, which lasted up to one year. The results of the COMPARE study, initiated at Charit\u00e9 and involving scientists from the DRFZ, were published in the journal Nature Medicine.<\/p>\n\n\n\n<div class=\"wp-block-buttons alignwide is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.charite.de\/service\/pressemitteilung\/artikel\/detail\/zelltherapie_bei_schwerer_rheumatoider_arthritis_erfolgreich\/\" rel=\"Pressemitteilung Charit\u00e9\">Press release by Charit\u00e9<\/a><\/div>\n<\/div>\n\n\n\n  <section id=\"originalpublikation\" class=\"section links-list  alignwide  toc-item\">\n    <div class=\"container container--center\">\n                        <h2 class=\"section__heading launimation slideBottom\">Original publication<\/h2>\n        \n              \n      <div class=\"links-list__items-wrap\">\n        \n<div class=\"links-list__items links-list__items--row \">\n      <div class=\"links-list__item  launimation slideBottom\">\n      \n      <a href=\"https:\/\/www.nature.com\/articles\/s41591-026-04603-3\" target=\"_self\" class=\"h6 links-list__item-title\">Albach, F.N., Rehm, M.C., H\u00fctter-Kr\u00f6nke, M.L. et al. CD19 CAR T cell therapy for treatment-refractory seropositive rheumatoid arthritis: a phase 1 trial. Nat Med (2026). https:\/\/doi.org\/10.1038\/s41591-026-04603-3<\/a>\n\n      \n      <a href=\"https:\/\/www.nature.com\/articles\/s41591-026-04603-3\" target=\"_self\" class=\"links-list__item-link\">\n        <span class=\"button button--arrow button--arrow-nw button--arrow-link\" ><\/span>\n      <\/a>\n    <\/div>\n  <\/div>\n      <\/div>\n    <\/div>\n  <\/section>\n\n\n\n\n  <section id=\"projektleiter\"    class=\"section grid-heads alignwide toc-item\">\n    <div class=\"container container--center\">\n              <div class=\"grid-heads__header\">\n                      <h2 class=\"section__heading launimation slideBottom\">Projekt leader<\/h2>\n          \n                  <\/div>\n      \n              <div class=\"grid-heads__items grid grid--4\">\n          \n<article\n  id=\"post-3781\" class=\"teaser-head launimation slideBottom  post-3781 head type-head status-publish has-post-thumbnail hentry department-pa-4-translational-rheumatology liaison-charite-rheumatology-and-clinical-immunology programme-area-tax-programme-area-4 working-group-function-group-leader\">\n  <div class=\"teaser-head__image\">\n          <img decoding=\"async\" loading=\"lazy\" sizes=\"auto, 520px\" src=\"https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/01\/Kroenke-Gerhard_Foto_J-Hirscher-150x100.jpg\" data-src=\"https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/01\/Kroenke-Gerhard_Foto_J-Hirscher-1024x682.jpg\" data-srcset=\"https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/01\/Kroenke-Gerhard_Foto_J-Hirscher-1920x1280.jpg 1920w, https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/01\/Kroenke-Gerhard_Foto_J-Hirscher-1600x1066.jpg 1600w, https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/01\/Kroenke-Gerhard_Foto_J-Hirscher-1366x910.jpg 1366w, https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/01\/Kroenke-Gerhard_Foto_J-Hirscher-1024x682.jpg 1024w, https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/01\/Kroenke-Gerhard_Foto_J-Hirscher-768x512.jpg 768w, https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/01\/Kroenke-Gerhard_Foto_J-Hirscher-550x367.jpg 550w\" class=\"image image--landscape\" alt=\"\"  width=\"1024\"  height=\"682\">      <\/div>\n  <div class=\"teaser-head__header\">\n    <!--    -->    <!--      -->    <!--    -->    <h2 class=\"h6 teaser-head__title launimation slideBottom\">Prof. Dr. Gerhard Kr\u00f6nke<\/h2>\n          <div class=\"teaser-head__role\">\n                                          <p\n            class=\"text-label liaison\">Liaison working group with Charit\u00e9 &#8211; Rheumatology and Clinical Immunology<\/p>\n              <\/div>\n      <\/div>\n\n      <div class=\"teaser-head__contact\">\n              <p class=\"text-label\"><a href=\"mailto:gerhard.kroenke@charite.de\"\">gerhard.kroenke@charite.de<\/a><\/p>\n          <\/div>\n    <a href=\"https:\/\/www.drfz.de\/en\/koepfe\/gerhard-kronke\/\"\n    aria-describedby=\"post-3781\"\n    title=\"Gehe zum Beitrag\" rel=\"bookmark\"\n    class=\"teaser-head__link button button--small button--arrow button--arrow-link\"><span\n      class=\"visually-hidden\">Prof. Dr. Gerhard Kr\u00f6nke<\/span><\/a>\n<\/article>        <\/div>\n          <\/div>\n  <\/section>\n","protected":false},"excerpt":{"rendered":"<p>CAR-T Cells Slow Down Severe RA CAR-T cells are body\u2019s own immune cells that have been genetically modified in the laboratory. This enables them to\u2026<\/p>\n","protected":false},"author":4,"featured_media":24446,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[288,291],"tags":[442,489,497],"programme-area-tax":[182],"working-group-tax":[253],"class_list":["post-24447","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-for-patients","category-publications","tag-clinical-rheumatology","tag-kroenke","tag-program-area-4","programme-area-tax-programme-area-4","working-group-tax-clinical-rheumatology"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>CAR-T Cell Therapy Shows Promise for Severe Rheumatoid Arthritis - DRFZ<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.drfz.de\/en\/neuigkeiten\/car-t-cell-therapy-shows-promise-for-severe-rheumatoid-arthritis\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"CAR-T Cell Therapy Shows Promise for Severe Rheumatoid Arthritis - DRFZ\" \/>\n<meta property=\"og:description\" content=\"CAR-T Cells Slow Down Severe RA CAR-T cells are body\u2019s own immune cells that have been genetically modified in the laboratory. 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