{"id":8511,"date":"2024-04-15T14:29:00","date_gmt":"2024-04-15T14:29:00","guid":{"rendered":"https:\/\/www.drfz.de\/news\/neuen-wirkmechanismus-von-kortison-entschluesselt\/"},"modified":"2025-02-14T15:12:31","modified_gmt":"2025-02-14T15:12:31","slug":"neuen-wirkmechanismus-von-kortison-entschluesselt","status":"publish","type":"post","link":"https:\/\/www.drfz.de\/en\/neuigkeiten\/neuen-wirkmechanismus-von-kortison-entschluesselt\/","title":{"rendered":"New mechanism of cortisone action deciphered"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Cortisone has been used for decades to treat chronic inflammation, for example is patients with rheumatic diseases; however, the underlying molecular mechanism of action was largely unclear. A research team led by Prof Dr Gerhard Kr\u00f6nke (Charit\u00e9 and DRFZ) and involving Prof Dr Eicke Latz (DRFZ and Charit\u00e9) has now discovered that cortisone reprograms the metabolism of immune cells, which activates the body\u2019s own inflammatory brake. These findings enable the development of anti-inflammatory drugs with fewer side effects and have recently been published in the journal&nbsp;<em>Nature<\/em>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The study focussed on macrophages, immune cells that play a crucial role in chronic inflammation such as rheumatic disease. The researchers found that cortisone not only influences genes, but also reverses changes in cell metabolism triggered by inflammatory stimuli. This mechanism particularly affects the production of the anti-inflammatory molecule itaconate. Itaconate is secreted by mitochondria, the energy power engines of the cells. During inflammation, however, mitochondria switch their metabolism to \u201cdefence\u201d and itaconate production is inhibited. Permanent failure of the immune brake leads to chronic inflammation. Cortisone can reprogramme the metabolism of the macrophages and thus stimulate the production of itaconate in these cells, thereby inhibiting inflammation.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Several teams were involved in the study from the Medical Clinic for Rheumatology Charit\u00e9-Universit\u00e4tsmedizin Berlin, DRFZ, University Hospital Erlangen and the University of Ulm.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.charite.de\/service\/pressemitteilung\/artikel\/detail\/wie_der_kampfmodus_im_koerper_beendet_wird\/\" target=\"_blank\" rel=\"noreferrer noopener\">Link to press release of the Charit\u00e9\u00a0<br><\/a><\/div>\n<\/div>\n\n\n\n  <section     class=\"section grid-heads alignwide\">\n    <div class=\"container container--center\">\n      \n              <div class=\"grid-heads__items grid grid--4\">\n          \n<article\n  id=\"post-1685\" class=\"teaser-head launimation slideBottom  post-1685 head type-head status-publish has-post-thumbnail hentry department-directors department-pa-1-cell-and-tissue-rheumatology function-scientific-director programme-area-tax-programme-area-1 working-group-function-group-leader working-group-tax-immunobiology-of-inflammation\">\n  <div class=\"teaser-head__image\">\n          <img decoding=\"async\" loading=\"lazy\" sizes=\"auto, 520px\" src=\"https:\/\/www.drfz.de\/wp-content\/uploads\/2024\/12\/Frame-8635-150x97.png\" data-src=\"https:\/\/www.drfz.de\/wp-content\/uploads\/2024\/12\/Frame-8635-1024x664.png\" data-srcset=\"https:\/\/www.drfz.de\/wp-content\/uploads\/2024\/12\/Frame-8635.png 1920w, https:\/\/www.drfz.de\/wp-content\/uploads\/2024\/12\/Frame-8635.png 1600w, https:\/\/www.drfz.de\/wp-content\/uploads\/2024\/12\/Frame-8635.png 1366w, https:\/\/www.drfz.de\/wp-content\/uploads\/2024\/12\/Frame-8635-1024x664.png 1024w, https:\/\/www.drfz.de\/wp-content\/uploads\/2024\/12\/Frame-8635-768x498.png 768w, https:\/\/www.drfz.de\/wp-content\/uploads\/2024\/12\/Frame-8635-550x357.png 550w\" class=\"image image--landscape\" alt=\"\"  width=\"1024\"  height=\"664\">      <\/div>\n  <div class=\"teaser-head__header\">\n    <!--    -->    <!--      -->    <!--    -->    <h2 class=\"h6 teaser-head__title launimation slideBottom\">Prof. Dr. med. Eicke Latz<\/h2>\n          <div class=\"teaser-head__role\">\n                  <p class=\"text-label function\">Scientific Director<\/p>\n                          <p class=\"text-label programme_area_function programme_area department\">\n            Programme Area 1, Directors          <\/p>\n                          <p class=\"text-label working_group_function working_group\">\n            Group leader: Immunobiology of inflammation          <\/p>\n                      <\/div>\n      <\/div>\n\n      <div class=\"teaser-head__contact\">\n              <p class=\"text-label\"><a href=\"mailto:eicke.latz@drfz.de\"\">eicke.latz@drfz.de<\/a><\/p>\n          <\/div>\n    <a href=\"https:\/\/www.drfz.de\/en\/koepfe\/eicke-latz\/\"\n    aria-describedby=\"post-1685\"\n    title=\"Gehe zum Beitrag\" rel=\"bookmark\"\n    class=\"teaser-head__link button button--small button--arrow button--arrow-link\"><span\n      class=\"visually-hidden\">Prof. Dr. med. Eicke Latz<\/span><\/a>\n<\/article>\n<article\n  id=\"post-3781\" class=\"teaser-head launimation slideBottom  post-3781 head type-head status-publish has-post-thumbnail hentry department-pa-4-translational-rheumatology liaison-charite-rheumatology-and-clinical-immunology programme-area-tax-programme-area-4 working-group-function-group-leader\">\n  <div class=\"teaser-head__image\">\n          <img decoding=\"async\" loading=\"lazy\" sizes=\"auto, 520px\" src=\"https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/01\/Kroenke-Gerhard_Foto_J-Hirscher-150x100.jpg\" data-src=\"https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/01\/Kroenke-Gerhard_Foto_J-Hirscher-1024x682.jpg\" data-srcset=\"https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/01\/Kroenke-Gerhard_Foto_J-Hirscher-1920x1280.jpg 1920w, https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/01\/Kroenke-Gerhard_Foto_J-Hirscher-1600x1066.jpg 1600w, https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/01\/Kroenke-Gerhard_Foto_J-Hirscher-1366x910.jpg 1366w, https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/01\/Kroenke-Gerhard_Foto_J-Hirscher-1024x682.jpg 1024w, https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/01\/Kroenke-Gerhard_Foto_J-Hirscher-768x512.jpg 768w, https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/01\/Kroenke-Gerhard_Foto_J-Hirscher-550x367.jpg 550w\" class=\"image image--landscape\" alt=\"\"  width=\"1024\"  height=\"682\">      <\/div>\n  <div class=\"teaser-head__header\">\n    <!--    -->    <!--      -->    <!--    -->    <h2 class=\"h6 teaser-head__title launimation slideBottom\">Prof. Dr. Gerhard Kr\u00f6nke<\/h2>\n          <div class=\"teaser-head__role\">\n                          <p class=\"text-label programme_area_function programme_area department\">\n            Programme Area 4, PA 4 \u2013 Translational Rheumatology          <\/p>\n                                  <p\n            class=\"text-label liaison\">Liaison working group with Charit\u00e9 &#8211; Rheumatology and Clinical Immunology<\/p>\n              <\/div>\n      <\/div>\n\n      <div class=\"teaser-head__contact\">\n              <p class=\"text-label\"><a href=\"mailto:gerhard.kroenke@charite.de\"\">gerhard.kroenke@charite.de<\/a><\/p>\n          <\/div>\n    <a href=\"https:\/\/www.drfz.de\/en\/koepfe\/gerhard-kronke\/\"\n    aria-describedby=\"post-3781\"\n    title=\"Gehe zum Beitrag\" rel=\"bookmark\"\n    class=\"teaser-head__link button button--small button--arrow button--arrow-link\"><span\n      class=\"visually-hidden\">Prof. Dr. Gerhard Kr\u00f6nke<\/span><\/a>\n<\/article>        <\/div>\n          <\/div>\n  <\/section>\n\n\n\n  <section id=\"block_09d2fdae164c353edb64501b16697873\" class=\"section links-list  alignwide \">\n    <div class=\"container container--center\">\n      \n      <div class=\"links-list__items-wrap\">\n        \n<div class=\"links-list__items links-list__items--row \">\n      <div class=\"links-list__item  launimation slideBottom\">\n      \n      <a href=\"https:\/\/www.nature.com\/articles\/s41586-024-07282-7\" target=\"_blank\" class=\"h6 links-list__item-title\">original publication<\/a>\n\n              <span class=\"links-list__item-underline\">Auger JP, Zimmermann M, Faas M, Stifel U, Chambers D, Krishnacoumar B, Taudte RV, Grund C, Erdmann G, Scholtysek C, Uderhardt S, Ben Brahim O, Pascual Mat\u00e9 M, Stoll C, B\u00f6ttcher M, Palumbo-Zerr K, Mangan MSJ, Dzamukova M, Kieler M, Hofmann M, Bl\u00fcml S, Schabbauer G, Mougiakakos D, Sonnewald U, Hartmann F, Simon D, Kleyer A, Gr\u00fcneboom A, Finotto S, Latz E, Hofmann J, Schett G, Tuckermann J, Kr\u00f6nke G. Metabolic rewiring promotes anti-inflammatory effects of glucocorticoids. Nature. 2024 Apr 10. doi: 10.1038\/s41586-024-07282-7. Epub ahead of print. PMID: 38600378.<\/span>\n      \n      <a href=\"https:\/\/www.nature.com\/articles\/s41586-024-07282-7\" target=\"_blank\" class=\"links-list__item-link\">\n        <span class=\"button button--arrow button--arrow-nw button--arrow-link\" ><\/span>\n      <\/a>\n    <\/div>\n  <\/div>\n      <\/div>\n    <\/div>\n  <\/section>\n\n","protected":false},"excerpt":{"rendered":"<p>Cortisone has been used for decades to treat chronic inflammation, for example is patients with rheumatic diseases; however, the underlying molecular mechanism of action was\u2026<\/p>\n","protected":false},"author":9,"featured_media":4709,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[291],"tags":[442,403,489,448,492,497],"programme-area-tax":[179,182],"working-group-tax":[250],"class_list":["post-8511","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publications","tag-clinical-rheumatology","tag-immunobiology-of-inflammation","tag-kroenke","tag-latz","tag-program-area-1","tag-program-area-4","programme-area-tax-programme-area-1","programme-area-tax-programme-area-4","working-group-tax-immunobiology-of-inflammation"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>New mechanism of cortisone action deciphered - DRFZ<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.drfz.de\/en\/neuigkeiten\/neuen-wirkmechanismus-von-kortison-entschluesselt\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New mechanism of cortisone action deciphered - DRFZ\" \/>\n<meta property=\"og:description\" content=\"Cortisone has been used for decades to treat chronic inflammation, for example is patients with rheumatic diseases; however, the underlying molecular mechanism of action was\u2026\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.drfz.de\/en\/neuigkeiten\/neuen-wirkmechanismus-von-kortison-entschluesselt\/\" \/>\n<meta property=\"og:site_name\" content=\"DRFZ\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/drfz.de\/\" \/>\n<meta property=\"article:published_time\" content=\"2024-04-15T14:29:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-02-14T15:12:31+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/02\/2024_04_15_Wirkmechanismus_Kortison_AdobeStock_2018384.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"800\" \/>\n\t<meta property=\"og:image:height\" content=\"450\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Viet Hoang\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@DRFZ_Berlin\" \/>\n<meta name=\"twitter:site\" content=\"@DRFZ_Berlin\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Viet Hoang\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/neuigkeiten\\\/neuen-wirkmechanismus-von-kortison-entschluesselt\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/neuigkeiten\\\/neuen-wirkmechanismus-von-kortison-entschluesselt\\\/\"},\"author\":{\"name\":\"Viet Hoang\",\"@id\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/#\\\/schema\\\/person\\\/bfb3defd73223982109dc1eafd951bd3\"},\"headline\":\"New mechanism of cortisone action deciphered\",\"datePublished\":\"2024-04-15T14:29:00+00:00\",\"dateModified\":\"2025-02-14T15:12:31+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/neuigkeiten\\\/neuen-wirkmechanismus-von-kortison-entschluesselt\\\/\"},\"wordCount\":236,\"publisher\":{\"@id\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/neuigkeiten\\\/neuen-wirkmechanismus-von-kortison-entschluesselt\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.drfz.de\\\/wp-content\\\/uploads\\\/2025\\\/02\\\/2024_04_15_Wirkmechanismus_Kortison_AdobeStock_2018384.jpg\",\"keywords\":[\"Clinical Rheumatology\",\"Immunobiology of Inflammation\",\"Kr\u00f6nke\",\"Latz\",\"Program area 1\",\"Program area 4\"],\"articleSection\":[\"Publications\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/neuigkeiten\\\/neuen-wirkmechanismus-von-kortison-entschluesselt\\\/\",\"url\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/neuigkeiten\\\/neuen-wirkmechanismus-von-kortison-entschluesselt\\\/\",\"name\":\"New mechanism of cortisone action deciphered - DRFZ\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/neuigkeiten\\\/neuen-wirkmechanismus-von-kortison-entschluesselt\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/neuigkeiten\\\/neuen-wirkmechanismus-von-kortison-entschluesselt\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.drfz.de\\\/wp-content\\\/uploads\\\/2025\\\/02\\\/2024_04_15_Wirkmechanismus_Kortison_AdobeStock_2018384.jpg\",\"datePublished\":\"2024-04-15T14:29:00+00:00\",\"dateModified\":\"2025-02-14T15:12:31+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/neuigkeiten\\\/neuen-wirkmechanismus-von-kortison-entschluesselt\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.drfz.de\\\/en\\\/neuigkeiten\\\/neuen-wirkmechanismus-von-kortison-entschluesselt\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/neuigkeiten\\\/neuen-wirkmechanismus-von-kortison-entschluesselt\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.drfz.de\\\/wp-content\\\/uploads\\\/2025\\\/02\\\/2024_04_15_Wirkmechanismus_Kortison_AdobeStock_2018384.jpg\",\"contentUrl\":\"https:\\\/\\\/www.drfz.de\\\/wp-content\\\/uploads\\\/2025\\\/02\\\/2024_04_15_Wirkmechanismus_Kortison_AdobeStock_2018384.jpg\",\"width\":800,\"height\":450},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/neuigkeiten\\\/neuen-wirkmechanismus-von-kortison-entschluesselt\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"News\",\"item\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/news\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"New mechanism of cortisone action deciphered\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/\",\"name\":\"DRFZ\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/#organization\",\"name\":\"Deutsches Rheuma-Forschungszentrum\",\"url\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.drfz.de\\\/wp-content\\\/uploads\\\/2024\\\/10\\\/drfz-footer-logo.svg\",\"contentUrl\":\"https:\\\/\\\/www.drfz.de\\\/wp-content\\\/uploads\\\/2024\\\/10\\\/drfz-footer-logo.svg\",\"width\":1,\"height\":1,\"caption\":\"Deutsches Rheuma-Forschungszentrum\"},\"image\":{\"@id\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/drfz.de\\\/\",\"https:\\\/\\\/x.com\\\/DRFZ_Berlin\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/deutsches-rheuma-forschungszentrum-berlin\",\"https:\\\/\\\/www.youtube.com\\\/channel\\\/UCf8nDuqpkWwcmCWmfSTkE3w\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.drfz.de\\\/en\\\/#\\\/schema\\\/person\\\/bfb3defd73223982109dc1eafd951bd3\",\"name\":\"Viet Hoang\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/f8b96e1b0aba912be35271142abfbb8039fdd9593cd9d332398b53a8f5b7156e?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/f8b96e1b0aba912be35271142abfbb8039fdd9593cd9d332398b53a8f5b7156e?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/f8b96e1b0aba912be35271142abfbb8039fdd9593cd9d332398b53a8f5b7156e?s=96&d=mm&r=g\",\"caption\":\"Viet Hoang\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"New mechanism of cortisone action deciphered - DRFZ","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.drfz.de\/en\/neuigkeiten\/neuen-wirkmechanismus-von-kortison-entschluesselt\/","og_locale":"en_US","og_type":"article","og_title":"New mechanism of cortisone action deciphered - DRFZ","og_description":"Cortisone has been used for decades to treat chronic inflammation, for example is patients with rheumatic diseases; however, the underlying molecular mechanism of action was\u2026","og_url":"https:\/\/www.drfz.de\/en\/neuigkeiten\/neuen-wirkmechanismus-von-kortison-entschluesselt\/","og_site_name":"DRFZ","article_publisher":"https:\/\/www.facebook.com\/drfz.de\/","article_published_time":"2024-04-15T14:29:00+00:00","article_modified_time":"2025-02-14T15:12:31+00:00","og_image":[{"width":800,"height":450,"url":"https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/02\/2024_04_15_Wirkmechanismus_Kortison_AdobeStock_2018384.jpg","type":"image\/jpeg"}],"author":"Viet Hoang","twitter_card":"summary_large_image","twitter_creator":"@DRFZ_Berlin","twitter_site":"@DRFZ_Berlin","twitter_misc":{"Written by":"Viet Hoang","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.drfz.de\/en\/neuigkeiten\/neuen-wirkmechanismus-von-kortison-entschluesselt\/#article","isPartOf":{"@id":"https:\/\/www.drfz.de\/en\/neuigkeiten\/neuen-wirkmechanismus-von-kortison-entschluesselt\/"},"author":{"name":"Viet Hoang","@id":"https:\/\/www.drfz.de\/en\/#\/schema\/person\/bfb3defd73223982109dc1eafd951bd3"},"headline":"New mechanism of cortisone action deciphered","datePublished":"2024-04-15T14:29:00+00:00","dateModified":"2025-02-14T15:12:31+00:00","mainEntityOfPage":{"@id":"https:\/\/www.drfz.de\/en\/neuigkeiten\/neuen-wirkmechanismus-von-kortison-entschluesselt\/"},"wordCount":236,"publisher":{"@id":"https:\/\/www.drfz.de\/en\/#organization"},"image":{"@id":"https:\/\/www.drfz.de\/en\/neuigkeiten\/neuen-wirkmechanismus-von-kortison-entschluesselt\/#primaryimage"},"thumbnailUrl":"https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/02\/2024_04_15_Wirkmechanismus_Kortison_AdobeStock_2018384.jpg","keywords":["Clinical Rheumatology","Immunobiology of Inflammation","Kr\u00f6nke","Latz","Program area 1","Program area 4"],"articleSection":["Publications"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.drfz.de\/en\/neuigkeiten\/neuen-wirkmechanismus-von-kortison-entschluesselt\/","url":"https:\/\/www.drfz.de\/en\/neuigkeiten\/neuen-wirkmechanismus-von-kortison-entschluesselt\/","name":"New mechanism of cortisone action deciphered - DRFZ","isPartOf":{"@id":"https:\/\/www.drfz.de\/en\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.drfz.de\/en\/neuigkeiten\/neuen-wirkmechanismus-von-kortison-entschluesselt\/#primaryimage"},"image":{"@id":"https:\/\/www.drfz.de\/en\/neuigkeiten\/neuen-wirkmechanismus-von-kortison-entschluesselt\/#primaryimage"},"thumbnailUrl":"https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/02\/2024_04_15_Wirkmechanismus_Kortison_AdobeStock_2018384.jpg","datePublished":"2024-04-15T14:29:00+00:00","dateModified":"2025-02-14T15:12:31+00:00","breadcrumb":{"@id":"https:\/\/www.drfz.de\/en\/neuigkeiten\/neuen-wirkmechanismus-von-kortison-entschluesselt\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.drfz.de\/en\/neuigkeiten\/neuen-wirkmechanismus-von-kortison-entschluesselt\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.drfz.de\/en\/neuigkeiten\/neuen-wirkmechanismus-von-kortison-entschluesselt\/#primaryimage","url":"https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/02\/2024_04_15_Wirkmechanismus_Kortison_AdobeStock_2018384.jpg","contentUrl":"https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/02\/2024_04_15_Wirkmechanismus_Kortison_AdobeStock_2018384.jpg","width":800,"height":450},{"@type":"BreadcrumbList","@id":"https:\/\/www.drfz.de\/en\/neuigkeiten\/neuen-wirkmechanismus-von-kortison-entschluesselt\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.drfz.de\/en\/"},{"@type":"ListItem","position":2,"name":"News","item":"https:\/\/www.drfz.de\/en\/news\/"},{"@type":"ListItem","position":3,"name":"New mechanism of cortisone action deciphered"}]},{"@type":"WebSite","@id":"https:\/\/www.drfz.de\/en\/#website","url":"https:\/\/www.drfz.de\/en\/","name":"DRFZ","description":"","publisher":{"@id":"https:\/\/www.drfz.de\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.drfz.de\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.drfz.de\/en\/#organization","name":"Deutsches Rheuma-Forschungszentrum","url":"https:\/\/www.drfz.de\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.drfz.de\/en\/#\/schema\/logo\/image\/","url":"https:\/\/www.drfz.de\/wp-content\/uploads\/2024\/10\/drfz-footer-logo.svg","contentUrl":"https:\/\/www.drfz.de\/wp-content\/uploads\/2024\/10\/drfz-footer-logo.svg","width":1,"height":1,"caption":"Deutsches Rheuma-Forschungszentrum"},"image":{"@id":"https:\/\/www.drfz.de\/en\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/drfz.de\/","https:\/\/x.com\/DRFZ_Berlin","https:\/\/www.linkedin.com\/company\/deutsches-rheuma-forschungszentrum-berlin","https:\/\/www.youtube.com\/channel\/UCf8nDuqpkWwcmCWmfSTkE3w"]},{"@type":"Person","@id":"https:\/\/www.drfz.de\/en\/#\/schema\/person\/bfb3defd73223982109dc1eafd951bd3","name":"Viet Hoang","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/f8b96e1b0aba912be35271142abfbb8039fdd9593cd9d332398b53a8f5b7156e?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/f8b96e1b0aba912be35271142abfbb8039fdd9593cd9d332398b53a8f5b7156e?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/f8b96e1b0aba912be35271142abfbb8039fdd9593cd9d332398b53a8f5b7156e?s=96&d=mm&r=g","caption":"Viet Hoang"}}]}},"_links":{"self":[{"href":"https:\/\/www.drfz.de\/en\/wp-json\/wp\/v2\/posts\/8511","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.drfz.de\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.drfz.de\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.drfz.de\/en\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/www.drfz.de\/en\/wp-json\/wp\/v2\/comments?post=8511"}],"version-history":[{"count":1,"href":"https:\/\/www.drfz.de\/en\/wp-json\/wp\/v2\/posts\/8511\/revisions"}],"predecessor-version":[{"id":8512,"href":"https:\/\/www.drfz.de\/en\/wp-json\/wp\/v2\/posts\/8511\/revisions\/8512"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.drfz.de\/en\/wp-json\/wp\/v2\/media\/4709"}],"wp:attachment":[{"href":"https:\/\/www.drfz.de\/en\/wp-json\/wp\/v2\/media?parent=8511"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.drfz.de\/en\/wp-json\/wp\/v2\/categories?post=8511"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.drfz.de\/en\/wp-json\/wp\/v2\/tags?post=8511"},{"taxonomy":"programme-area-tax","embeddable":true,"href":"https:\/\/www.drfz.de\/en\/wp-json\/wp\/v2\/programme-area-tax?post=8511"},{"taxonomy":"working-group-tax","embeddable":true,"href":"https:\/\/www.drfz.de\/en\/wp-json\/wp\/v2\/working-group-tax?post=8511"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}