{"id":3458,"date":"2025-01-21T15:35:39","date_gmt":"2025-01-21T15:35:39","guid":{"rendered":"https:\/\/www.drfz.de\/?post_type=working-group&#038;p=3458"},"modified":"2025-07-10T09:45:09","modified_gmt":"2025-07-10T09:45:09","slug":"entzundungsmechanismen","status":"publish","type":"working-group","link":"https:\/\/www.drfz.de\/en\/arbeitsgruppen\/entzundungsmechanismen\/","title":{"rendered":"Inflammatory Mechanisms"},"content":{"rendered":"\n  <section id=\"about-us\"\n           class=\"section accordion  alignwide  toc-item\"\n           data-open=\"multiple\">\n    <div class=\"container container--center container--medium\">\n              <h2 class=\"h3 section__heading launimation slideBottom\">About us<\/h2>\n      \n      \n      \n              <div id=\"panel-\"\n             class=\"accordion__category active\" role=\"tabpanel\"\n             aria-labelledby=\"tab-\">\n                    <script type=\"application\/ld+json\">\n            {\n              \"@context\": \"https:\/\/schema.org\",\n              \"@type\": \"FAQPage\",\n              \"mainEntity\": [{\"@type\": \"Question\",\"name\": \"Molecular signature of T cells in the intestine\",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"We have several diverse projects running with the common aim of identifying novel inflammatory signatures that may be amenable to therapeutic blockade, or be predictive markers of treatment failure. We wish to examine the link between bacterial opsonisation by the immune system and the CD4+ T cell responses to these bacteria, with the aim of identifying pathogenic and protective T cell signatures. Previous work has identified a novel role for oncostatin M (OSM) in mice and humans. Upregulation of OSM was found to be a predictive marker for anti-TNF treatment failure in IBD and blockade of OSM in vivo ameliorated disease symptoms in a mouse model of colitis. Therefore, we wish to exploit dysbiosis- and genetic-driven IBD mouse models and primary human tissue samples to explore the impact of OSM on intestinal epithelial cells and barrier functions in health and disease.\"}},{\"@type\": \"Question\",\"name\": \"T-cell-microbiome crosstalk in chronic inflammatory bowel diseases\",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"A comprehensive understanding of how the microbiota-immune system crosstalk is perturbed in chronic inflammation is essential, particularly in light of the high rate of treatment failure. Using a combination of mouse and human T cell immunology, mucosal immunology and animal models of disease as well as clinical specimens and sequence based approaches, we aim to identify environmental, microbial and inflammatory drivers that promote maladaptation and gut tissue inflammation. Our focus on clinical samples ensure that the work we carry out is of high relevance to patients and increases the likelihood of us delivering findings of future clinical relevance.\"}}]\n            }\n          <\/script>\n\n          <div class=\"accordion__content\">\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69dfd40e0bbf8_0\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">Molecular signature of T cells in the intestine<\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69dfd40e0bbf8_0\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p>We have several diverse projects running with the common aim of identifying novel inflammatory signatures that may be amenable to therapeutic blockade, or be predictive markers of treatment failure. We wish to examine the link between bacterial opsonisation by the immune system and the CD4+ T cell responses to these bacteria, with the aim of identifying pathogenic and protective T cell signatures. Previous work has identified a novel role for oncostatin M (OSM) in mice and humans. Upregulation of OSM was found to be a predictive marker for anti-TNF treatment failure in IBD and blockade of OSM <em>in vivo<\/em> ameliorated disease symptoms in a mouse model of colitis. Therefore, we wish to exploit dysbiosis- and genetic-driven IBD mouse models and primary human tissue samples to explore the impact of OSM on intestinal epithelial cells and barrier functions in health and disease.<\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69dfd40e0bbf8_1\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">T-cell-microbiome crosstalk in chronic inflammatory bowel diseases<\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69dfd40e0bbf8_1\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p>A comprehensive understanding of how the microbiota-immune system crosstalk is perturbed in chronic inflammation is essential, particularly in light of the high rate of treatment failure. Using a combination of mouse and human T cell immunology, mucosal immunology and animal models of disease as well as clinical specimens and sequence based approaches, we aim to identify environmental, microbial and inflammatory drivers that promote maladaptation and gut tissue inflammation. Our focus on clinical samples ensure that the work we carry out is of high relevance to patients and increases the likelihood of us delivering findings of future clinical relevance.<\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                      <\/div>\n        <\/div>\n          <\/div>\n  <\/section>\n\n\n\n\n  <section id=\"team\"\n           class=\"section accordion  alignwide  toc-item\"\n           data-open=\"multiple\">\n    <div class=\"container container--center container--medium\">\n              <h2 class=\"h3 section__heading launimation slideBottom\">Team<\/h2>\n      \n      \n      \n              <div id=\"panel-\"\n             class=\"accordion__category active\" role=\"tabpanel\"\n             aria-labelledby=\"tab-\">\n                    <script type=\"application\/ld+json\">\n            {\n              \"@context\": \"https:\/\/schema.org\",\n              \"@type\": \"FAQPage\",\n              \"mainEntity\": [{\"@type\": \"Question\",\"name\": \"Members\",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"Group leader\nProf. Ahmed Hegazy, M.D., Ph.D.\nProject coordinator\nAnna Miko\u0142ajczyk, Dipl. Biochem.\nPost Doc\nGino Kwon, Msc\nPh.D. students\nCamila Cancino, Msc\nLuis Velasco-Blasquez, Msc\nMariia Saliutina, Msc\nSoraya Abu-Sharki, Msc\nYanjiang Luo, M.D\nZhenjie Jin, M.D\nAgata Konopka (M.D.\/Ph.D.)\nMD students\nKim Juhran\nTechnical assistance\nCharles- Christian Mugisha, Research assistant &amp; Lab manager\n\u00a0\n\u00a0\n\u00a0\"}}]\n            }\n          <\/script>\n\n          <div class=\"accordion__content\">\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69dfd40e0c890_0\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">Members<\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69dfd40e0c890_0\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p><strong>Group leader<br \/>\n<\/strong>Prof. Ahmed Hegazy, M.D., Ph.D.<\/p>\n<p><strong>Project coordinator<br \/>\n<\/strong>Anna Miko\u0142ajczyk, Dipl. Biochem.<\/p>\n<p><strong>Post Doc<br \/>\n<\/strong>Gino Kwon, Msc<\/p>\n<p><strong>Ph.D. students<br \/>\n<\/strong>Camila Cancino, Msc<br \/>\nLuis Velasco-Blasquez, Msc<br \/>\nMariia Saliutina, Msc<br \/>\nSoraya Abu-Sharki, Msc<br \/>\nYanjiang Luo, M.D<br \/>\nZhenjie Jin, M.D<br \/>\nAgata Konopka (M.D.\/Ph.D.)<\/p>\n<p><strong>MD students<br \/>\n<\/strong>Kim Juhran<\/p>\n<p><strong>Technical assistance<br \/>\n<\/strong>Charles- Christian Mugisha, Research assistant &amp; Lab manager<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>\u00a0<\/strong><\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                      <\/div>\n        <\/div>\n          <\/div>\n  <\/section>\n\n\n\n\n  <section id=\"main-cooperation-partners\"\n           class=\"section accordion  alignwide  toc-item\"\n           data-open=\"multiple\">\n    <div class=\"container container--center container--medium\">\n              <h2 class=\"h3 section__heading launimation slideBottom\">Main cooperation partners<\/h2>\n      \n      \n      \n              <div id=\"panel-\"\n             class=\"accordion__category active\" role=\"tabpanel\"\n             aria-labelledby=\"tab-\">\n                    <script type=\"application\/ld+json\">\n            {\n              \"@context\": \"https:\/\/schema.org\",\n              \"@type\": \"FAQPage\",\n              \"mainEntity\": [{\"@type\": \"Question\",\"name\": \"Within DRFZ\/Charit\u00e9\",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"Max L\u00f6hning, Farzin Mashreghi, Chiara Romagnani, Andrey Kruglov, Carl Weidinger, Brita Siegmund, Andreas Diefenbach\"}},{\"@type\": \"Question\",\"name\": \"National academia\",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"Kevin Thurely, Christoph Becker, Sebastian Zundler, Stefan Wirtz, Thomas H\u00f6fer, Lukas Flatz\"}},{\"@type\": \"Question\",\"name\": \"International academia\",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"Zlatko Trajanoski, Andreas Bergthaler, Isabelle Arnold (ETH)\"}},{\"@type\": \"Question\",\"name\": \"International industry\",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"Zlatko Trajanoski, Andreas Bergthaler, Isabelle Arnold (ETH)\"}}]\n            }\n          <\/script>\n\n          <div class=\"accordion__content\">\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69dfd40e0d838_0\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">Within DRFZ\/Charit\u00e9<\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69dfd40e0d838_0\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p>Max L\u00f6hning, Farzin Mashreghi, Chiara Romagnani, Andrey Kruglov, Carl Weidinger, Brita Siegmund, Andreas Diefenbach<\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69dfd40e0d838_1\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">National academia<\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69dfd40e0d838_1\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p>Kevin Thurely, Christoph Becker, Sebastian Zundler, Stefan Wirtz, Thomas H\u00f6fer, Lukas Flatz<\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69dfd40e0d838_2\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">International academia<\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69dfd40e0d838_2\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p>Zlatko Trajanoski, Andreas Bergthaler, Isabelle Arnold (ETH)<\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69dfd40e0d838_3\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">International industry<\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69dfd40e0d838_3\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p>Zlatko Trajanoski, Andreas Bergthaler, Isabelle Arnold (ETH)<\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                      <\/div>\n        <\/div>\n          <\/div>\n  <\/section>\n\n\n\n\n  <section id=\"news\"\n           class=\"section related-news alignwide related-news--slider  toc-item\">\n    <div class=\"container container--center\">\n\n      <div class=\"related-news__wrap\">\n                  <div class=\"section__heading-container launimation slideBottom\">\n                          <h2 class=\"section__heading\">News<\/h2>\n                                  <\/div>\n        \n        \n        <div class=\"related-news__slider swiper swiper-pull-right\">\n                      <div class=\"slider__skip-links-container\">\n              <a id=\"before-slider-block_6815fcd4f9e39255e41fa741b3598703\"\n                 href=\"#after-slider-block_6815fcd4f9e39255e41fa741b3598703\"\n                 class=\"slider-skip-link\">Go to end of slider<\/a>\n            <\/div>\n          \n          <div class=\"swiper-wrapper grid graded-boxes\">\n                          <div class=\"swiper-slide\">\n                \n<article\n  id=\"post-17702\" class=\"teaser-post box box--min-height launimation slideBottom graded-box post-17702 post type-post status-publish format-standard has-post-thumbnail hentry category-news-en category-publications tag-hegazy_en tag-inflammatory-mechanisms-en tag-inflammatory-mechanisms tag-program-area-4 working-group-tax-inflammatory-mechanisms\">\n  <div class=\"teaser-post__wrap\">\n    <div class=\"teaser-post__cats\">\n      \n<ul class=\"tag-pills tag-pills--small\" role=\"none\">\n      <li role=\"none\">\n      <span class=\"tag-pill\">\n        <span class=\"visually-hidden\">Kategorie: <\/span>\n        News      <\/span>\n    <\/li>\n  <\/ul>    <\/div>\n\n    <div class=\"teaser-post__body\">\n      <time class=\"date\" datetime=\"2025-05-30 12:20:17\">30.05.2025<\/time>\n      <div class=\"teaser-post__title h5\">\n        <a href=\"https:\/\/www.drfz.de\/en\/neuigkeiten\/new-inflammatory-mechanism-discovered-in-chronic-intestinal-inflammation\/\" aria-describedby=\"post-17702\"\n          title=\"Gehe zum Beitrag\" rel=\"bookmark\">\n          New inflammatory mechanism discovered in chronic intestinal inflammation        <\/a>\n      <\/div>\n\n              <div class=\"teaser-post__excerpt ellipsis\">\n          Oncostatin M as a key target for therapies Chronic inflammatory bowel diseases such as Crohn&#8217;s disease and ulcerative colitis are difficult to treat and are\u2026        <\/div>\n          <\/div>\n  <\/div>\n<\/article>              <\/div>\n                          <div class=\"swiper-slide\">\n                \n<article\n  id=\"post-17475\" class=\"teaser-post box box--min-height launimation slideBottom graded-box post-17475 post type-post status-publish format-standard hentry category-for-patients category-news-en tag-clinical-rheumatology tag-developmental-mucosal-immunology tag-immunobiology-of-inflammation tag-inflammatory-mechanisms tag-innate-immunity tag-macrophages-in-chronic-inflammation tag-program-area-1 tag-program-area-4 working-group-tax-clinical-rheumatology working-group-tax-developmental-and-mucosal-immunology working-group-tax-immunobiology-of-inflammation working-group-tax-inflammatory-mechanisms working-group-tax-innate-immunity working-group-tax-macrophage-biology-and-innate-cellular-networks-in-chronic-inflammatory-diseases\">\n  <div class=\"teaser-post__wrap\">\n    <div class=\"teaser-post__cats\">\n      \n<ul class=\"tag-pills tag-pills--small\" role=\"none\">\n      <li role=\"none\">\n      <span class=\"tag-pill\">\n        <span class=\"visually-hidden\">Kategorie: <\/span>\n        For patients      <\/span>\n    <\/li>\n  <\/ul>    <\/div>\n\n    <div class=\"teaser-post__body\">\n      <time class=\"date\" datetime=\"2025-05-22 15:56:22\">22.05.2025<\/time>\n      <div class=\"teaser-post__title h5\">\n        <a href=\"https:\/\/www.drfz.de\/en\/neuigkeiten\/early-recognition-targeted-intervention-staying-healthy-immunoprecept-unites-top-berlin-research\/\" aria-describedby=\"post-17475\"\n          title=\"Gehe zum Beitrag\" rel=\"bookmark\">\n          Early recognition, targeted intervention, staying healthy: ImmunoPreCept unites top Berlin research        <\/a>\n      <\/div>\n\n              <div class=\"teaser-post__excerpt ellipsis\">\n          The DRFZ is part of the new Cluster of Excellence The German Rheumatology Research Center, a Leibniz Institute, is partner in the new Berlin Cluster\u2026        <\/div>\n          <\/div>\n  <\/div>\n<\/article>              <\/div>\n                          <div class=\"swiper-slide\">\n                \n<article\n  id=\"post-8328\" class=\"teaser-post box box--min-height launimation slideBottom graded-box post-8328 post type-post status-publish format-standard has-post-thumbnail hentry category-publications tag-ahmed-hegazy-en-en tag-inflammatory-mechanisms tag-program-area-4 programme-area-tax-programme-area-4 working-group-tax-inflammatory-mechanisms\">\n  <div class=\"teaser-post__wrap\">\n    <div class=\"teaser-post__cats\">\n      \n<ul class=\"tag-pills tag-pills--small\" role=\"none\">\n      <li role=\"none\">\n      <span class=\"tag-pill\">\n        <span class=\"visually-hidden\">Kategorie: <\/span>\n        Publications      <\/span>\n    <\/li>\n  <\/ul>    <\/div>\n\n    <div class=\"teaser-post__body\">\n      <time class=\"date\" datetime=\"2024-11-08 10:11:00\">08.11.2024<\/time>\n      <div class=\"teaser-post__title h5\">\n        <a href=\"https:\/\/www.drfz.de\/en\/neuigkeiten\/biomarker-fuer-therapieerfolg-bei-chronischen-darmentzuendungen-identifiziert\/\" aria-describedby=\"post-8328\"\n          title=\"Gehe zum Beitrag\" rel=\"bookmark\">\n          Biomarker identified that predicts therapeutic success in chronic inflammatory bowel disease        <\/a>\n      <\/div>\n\n              <div class=\"teaser-post__excerpt ellipsis\">\n          A research team led by Ahmed Hegzay, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin and DRFZ, has identified a biomarker that can predict whether anti-integrin therapy with the\u2026        <\/div>\n          <\/div>\n  <\/div>\n<\/article>              <\/div>\n            \n          <\/div><!-- swiper-wrapper -->\n\n                      <div class=\"slider__pagination slider__pagination--contained\">\n              <button class=\"slider__button-prev\"><\/button>\n              <button class=\"slider__button-next\"><\/button>\n            <\/div>\n          \n                      <div class=\"slider__skip-links-container\">\n              <a id=\"after-slider-block_6815fcd4f9e39255e41fa741b3598703\"\n                 href=\"#before-slider-block_6815fcd4f9e39255e41fa741b3598703\"\n                 class=\"skip-link\">Go to beginning of slider<\/a>\n            <\/div>\n                  <\/div>\n\n                        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more<\/a>\n<\/div>\n          <\/div>\n              <\/div>\n\n    <\/div><!-- container -->\n  <\/section>\n\n\n\n\n  <section id=\"projects\"\n           class=\"section related-projects alignwide related-projects--slider  toc-item\">\n    <div class=\"container container--center\">\n      <div class=\"related-projects__wrap\">\n                  <div class=\"section__heading-container launimation slideBottom\">\n                          <h2 class=\"section__heading\">Projects<\/h2>\n                                  <\/div>\n        \n        \n        <div class=\"related-projects__slider swiper swiper-pull-right\">\n                      <div class=\"slider__skip-links-container\">\n              <a id=\"before-slider-block_b9bdb0ac0f6fab93a5e8e3dd69281c04\"\n                 href=\"#after-slider-block_b9bdb0ac0f6fab93a5e8e3dd69281c04\"\n                 class=\"slider-skip-link\">Go to end of slider<\/a>\n            <\/div>\n          \n          <div class=\"swiper-wrapper grid graded-boxes\">\n                          <div class=\"swiper-slide\">\n                <article\n  id=\"post-17506\" class=\"teaser-project box launimation slideBottom graded-box post-17506 project type-project status-publish hentry supporter-dfg-en working-group-tax-developmental-and-mucosal-immunology working-group-tax-immunobiology-of-inflammation working-group-tax-inflammatory-mechanisms working-group-tax-innate-immunity working-group-tax-macrophage-biology-and-innate-cellular-networks-in-chronic-inflammatory-diseases\">\n  <div class=\"teaser-project__wrap\">\n          <div class=\"teaser-project__cats\">\n        \n<ul class=\"tag-pills tag-pills--small\" role=\"none\">\n      <li role=\"none\">\n      <span class=\"tag-pill\">\n        <span class=\"visually-hidden\">Kategorie: <\/span>\n        DFG      <\/span>\n    <\/li>\n  <\/ul>      <\/div>\n    \n    <div class=\"teaser-project__body\">\n      <div class=\"teaser-project__title h5\">\n        <a 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