{"id":3482,"date":"2025-01-21T15:32:19","date_gmt":"2025-01-21T15:32:19","guid":{"rendered":"https:\/\/www.drfz.de\/?post_type=working-group&#038;p=3482"},"modified":"2025-05-23T07:46:06","modified_gmt":"2025-05-23T07:46:06","slug":"entwicklung-des-immunsystems","status":"publish","type":"working-group","link":"https:\/\/www.drfz.de\/en\/arbeitsgruppen\/entwicklung-des-immunsystems\/","title":{"rendered":"Developmental and Mucosal Immunology"},"content":{"rendered":"\n  <section id=\"about-us\"\n           class=\"section accordion  alignwide  toc-item\"\n           data-open=\"multiple\">\n    <div class=\"container container--center container--medium\">\n              <h2 class=\"h3 section__heading launimation slideBottom\">About us<\/h2>\n      \n      \n      \n              <div id=\"panel-\"\n             class=\"accordion__category active\" role=\"tabpanel\"\n             aria-labelledby=\"tab-\">\n                    <script type=\"application\/ld+json\">\n            {\n              \"@context\": \"https:\/\/schema.org\",\n              \"@type\": \"FAQPage\",\n              \"mainEntity\": [{\"@type\": \"Question\",\"name\": \"Transcriptional control of ILC development and function\",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"Our lab has recently contributed to the discovery of innate lymphoid cells (ILCs), a group of tissue-resident innate lymphocytes located at border surfaces that release cytokines specifically acting on epithelial cells thereby contributing to tissue homeostasis and to the adaptation of the host in response to noxious compounds and tissue damage. A focus has been the analysis of transcriptional programs controlling lineage specification, commitment and function of ILCs. We recently identified a common, Id2-expressing progenitor to all \u2018helper-like\u2019 ILC lineages, the CHILP (Klose, Cell 2014). Our previous work has revealed that functional perturbations of ILC predispose to intestinal infections and to chronic inflammatory bowel diseases. It is likely, that such studies will identify new targets for the treatment of debilitating chronic inflammatory disorders.\"}},{\"@type\": \"Question\",\"name\": \"The role of the indigenous microbiota in calibrating innate immunity\",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"The role of environmental factors (microbiota, nutrients) for the formation of an effective and well calibrated innate immune response is recognized. Mononuclear phagocytes germ-free mice were unable to produce most pro-inflammatory cytokines (in particular type I IFN), and, consequently, germ-free mice were more susceptible to infections with viruses (Ganal, Immunity 2012). On a mechanistic level, we showed that signals of the microbiota are needed to remove a chromatin barrier required for the transcription of genes after ligation of pattern recognition receptors (PRR). Ongoing studies address the mechanistic underpinnings of this process as well as the microbiota-derived signals that tune mononuclear phagocyte responses. As many autoimmune diseases have a type I IFN signature, it is possible that dyscalibration of the mononuclear phagocytes by the microbiota may contribute to rheumatic diseases.\"}},{\"@type\": \"Question\",\"name\": \"The role of nutrients for development and function of the innate immune system\",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"Much has been learned about how the microbiota contributes to many aspects of host physiology. In contrast, the role of nutrients for development and function of the intestinal immune system has largely been a matter of speculation owing to the fact that molecular sensors of dietary molecules are widely unknown. Given the broad role of nutrients in metabolic diseases and the impact of intestinal cancer on human health, research into the question of how the power of nutrients can be harnessed for improving human health and for the prevention of disease is much warranted. We have recently found that the aryl hydrocarbon receptor (AhR), a transcription factor activated by small molecular ligands, is required for the development of innate immune system components by serving as a sensor for phytochemicals. Based on these preliminary data, we aim now to systematically define the role of diet-induced changes for the function and differentiation of mucosa-associated innate lymphocytes and to uncover how innate lymphocytes regulate epithelial adaptation by controlling niche support for intestinal epithelial stem cells.\"}}]\n            }\n          <\/script>\n\n          <div class=\"accordion__content\">\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69dc4bd334037_0\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">Transcriptional control of ILC development and function<\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69dc4bd334037_0\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p>Our lab has recently contributed to the discovery of innate lymphoid cells (ILCs), a group of tissue-resident innate lymphocytes located at border surfaces that release cytokines specifically acting on epithelial cells thereby contributing to tissue homeostasis and to the adaptation of the host in response to noxious compounds and tissue damage. A focus has been the analysis of transcriptional programs controlling lineage specification, commitment and function of ILCs. We recently identified a common, Id2-expressing progenitor to all \u2018helper-like\u2019 ILC lineages, the CHILP (Klose, Cell 2014). Our previous work has revealed that functional perturbations of ILC predispose to intestinal infections and to chronic inflammatory bowel diseases. It is likely, that such studies will identify new targets for the treatment of debilitating chronic inflammatory disorders.<\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69dc4bd334037_1\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">The role of the indigenous microbiota in calibrating innate immunity<\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69dc4bd334037_1\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p>The role of environmental factors (microbiota, nutrients) for the formation of an effective and well calibrated innate immune response is recognized. Mononuclear phagocytes germ-free mice were unable to produce most pro-inflammatory cytokines (in particular type I IFN), and, consequently, germ-free mice were more susceptible to infections with viruses (Ganal, Immunity 2012). On a mechanistic level, we showed that signals of the microbiota are needed to remove a chromatin barrier required for the transcription of genes after ligation of pattern recognition receptors (PRR). Ongoing studies address the mechanistic underpinnings of this process as well as the microbiota-derived signals that tune mononuclear phagocyte responses. As many autoimmune diseases have a type I IFN signature, it is possible that dyscalibration of the mononuclear phagocytes by the microbiota may contribute to rheumatic diseases.<\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69dc4bd334037_2\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">The role of nutrients for development and function of the innate immune system<\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69dc4bd334037_2\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p>Much has been learned about how the microbiota contributes to many aspects of host physiology. In contrast, the role of nutrients for development and function of the intestinal immune system has largely been a matter of speculation owing to the fact that molecular sensors of dietary molecules are widely unknown. Given the broad role of nutrients in metabolic diseases and the impact of intestinal cancer on human health, research into the question of how the power of nutrients can be harnessed for improving human health and for the prevention of disease is much warranted. We have recently found that the aryl hydrocarbon receptor (AhR), a transcription factor activated by small molecular ligands, is required for the development of innate immune system components by serving as a sensor for phytochemicals. Based on these preliminary data, we aim now to systematically define the role of diet-induced changes for the function and differentiation of mucosa-associated innate lymphocytes and to uncover how innate lymphocytes regulate epithelial adaptation by controlling niche support for intestinal epithelial stem cells.<\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                      <\/div>\n        <\/div>\n          <\/div>\n  <\/section>\n\n\n\n\n  <section id=\"team\"\n           class=\"section accordion  alignwide  toc-item\"\n           data-open=\"multiple\">\n    <div class=\"container container--center container--medium\">\n              <h2 class=\"h3 section__heading launimation slideBottom\">Team<\/h2>\n      \n      \n      \n              <div id=\"panel-\"\n             class=\"accordion__category active\" role=\"tabpanel\"\n             aria-labelledby=\"tab-\">\n                    <script type=\"application\/ld+json\">\n            {\n              \"@context\": \"https:\/\/schema.org\",\n              \"@type\": \"FAQPage\",\n              \"mainEntity\": [{\"@type\": \"Question\",\"name\": \"Members\",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"Group leader\nUniv. Prof. Dr. med. Andreas Diefenbach\nGroup Members\nAnna Fagundes\nStylianos Gnafakis\nLuke Houghton\nAtsuyo Ikeda\nLuise Kausch-Blecken\nMichael Kofoed-Branzk\nAnita Kowalczyk\nIrene Mattiola\nDiego Perez Vazquez\nAlmina Polinova\nBruno Rocha\nOmer Shomrat\nCaroline Tizian\nNilsu Turay\nMario Witkowski\"}}]\n            }\n          <\/script>\n\n          <div class=\"accordion__content\">\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69dc4bd334d40_0\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">Members<\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69dc4bd334d40_0\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p><strong>Group leader<\/strong><br \/>\nUniv. Prof. Dr. med. Andreas Diefenbach<\/p>\n<p><strong>Group Members<\/strong><br \/>\nAnna Fagundes<br \/>\nStylianos Gnafakis<br \/>\nLuke Houghton<br \/>\nAtsuyo Ikeda<br \/>\nLuise Kausch-Blecken<br \/>\nMichael Kofoed-Branzk<br \/>\nAnita Kowalczyk<br \/>\nIrene Mattiola<br \/>\nDiego Perez Vazquez<br \/>\nAlmina Polinova<br \/>\nBruno Rocha<br \/>\nOmer Shomrat<br \/>\nCaroline Tizian<br \/>\nNilsu Turay<br \/>\nMario Witkowski<\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                      <\/div>\n        <\/div>\n          <\/div>\n  <\/section>\n\n\n\n\n  <section id=\"main-cooperation-partners\"\n           class=\"section accordion  alignwide  toc-item\"\n           data-open=\"multiple\">\n    <div class=\"container container--center container--medium\">\n              <h2 class=\"h3 section__heading launimation slideBottom\">Main cooperation partners<\/h2>\n      \n      \n      \n              <div id=\"panel-\"\n             class=\"accordion__category active\" role=\"tabpanel\"\n             aria-labelledby=\"tab-\">\n                    <script type=\"application\/ld+json\">\n            {\n              \"@context\": \"https:\/\/schema.org\",\n              \"@type\": \"FAQPage\",\n              \"mainEntity\": [{\"@type\": \"Question\",\"name\": \"Within DRFZ\/Charit\u00e9\",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"Mir-Farzin Mashreghi, Anja Hauser, Chiara Romagnani, Eicke Latz, Andrey Kruglov, Antigoni Triantafyllopoulou, Max L\u00f6hning, Bastian Opitz, Christoph Klose\"}},{\"@type\": \"Question\",\"name\": \"National academia\",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"Caspar Ohnmacht\"}},{\"@type\": \"Question\",\"name\": \"International academia\",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"Salome Pinho, Greg Sonnenberg, Serge van de Pavert, Guiseppe Scium\u00e8\"}}]\n            }\n          <\/script>\n\n          <div class=\"accordion__content\">\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69dc4bd335adb_0\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">Within DRFZ\/Charit\u00e9<\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69dc4bd335adb_0\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p>Mir-Farzin Mashreghi, Anja Hauser, Chiara Romagnani, Eicke Latz, Andrey Kruglov, Antigoni Triantafyllopoulou, Max L\u00f6hning, Bastian Opitz, Christoph Klose<\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69dc4bd335adb_1\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">National academia<\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69dc4bd335adb_1\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p>Caspar Ohnmacht<\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69dc4bd335adb_2\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">International academia<\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69dc4bd335adb_2\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p>Salome Pinho, Greg Sonnenberg, Serge van de Pavert, Guiseppe Scium\u00e8<\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                      <\/div>\n        <\/div>\n          <\/div>\n  <\/section>\n\n\n\n\n  <section id=\"how-does-the-immune-system-cause-chronicity-in-rheumatic-inflammation\" class=\"section cta  alignwide toc-item\">\n    <div class=\"container container--center\">\n\n      <div class=\"cta__wrapper bg bg--surface\">\n        <div class=\"cta__content\">\n                      <h2 class=\"cta__heading launimation slideBottom\">More Information about<\/h2>\n          \n                      <div class=\"cta__desc wysiwyg launimation slideBottom\">How does the immune system cause chronicity in rheumatic inflammation?<\/div>\n          \n          \n                      <div class=\"cta__ctas button-group\">\n              <a href=\"http:\/\/charite-mikrobiologie.de\/diefenbach-lab\/\" class=\"cta__button button button--arrow launimation slideBottom\" title=\"\" target=\"_blank\"><span><\/span><\/a>            <\/div>\n                  <\/div><!-- content -->\n\n              <\/div><!-- wrapper -->\n\n    <\/div><!-- container -->\n  <\/section>\n\n\n\n\n  <section id=\"news\"\n           class=\"section related-news alignwide related-news--slider  toc-item\">\n    <div class=\"container container--center\">\n\n      <div class=\"related-news__wrap\">\n                  <div class=\"section__heading-container launimation slideBottom\">\n                          <h2 class=\"section__heading\">News<\/h2>\n                                  <\/div>\n        \n        \n     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The German Rheumatology Research Center, a Leibniz Institute, is partner in the new Berlin Cluster\u2026        <\/div>\n          <\/div>\n  <\/div>\n<\/article>              <\/div>\n            \n          <\/div><!-- swiper-wrapper -->\n\n          \n                  <\/div>\n\n                      <\/div>\n\n    <\/div><!-- container -->\n  <\/section>\n\n\n\n\n  <section id=\"projects\"\n           class=\"section related-projects alignwide related-projects--slider  toc-item\">\n    <div class=\"container container--center\">\n      <div class=\"related-projects__wrap\">\n                  <div class=\"section__heading-container launimation slideBottom\">\n                          <h2 class=\"section__heading\">Projects<\/h2>\n                                  <\/div>\n        \n        \n        <div class=\"related-projects__slider swiper swiper-pull-right\">\n                      <div class=\"slider__skip-links-container\">\n              <a 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graded-box post-4472 project type-project status-publish hentry programme-area-tax-programme-area-1 programme-area-tax-programme-area-2 programme-area-tax-programme-area-3 supporter-bmbf-en working-group-tax-chronic-inflammation-in-childhood working-group-tax-developmental-and-mucosal-immunology working-group-tax-paediatric-rheumatology-and-health-services-research working-group-tax-therapeutic-gene-regulation\">\n  <div class=\"teaser-project__wrap\">\n          <div class=\"teaser-project__cats\">\n        \n<ul class=\"tag-pills tag-pills--small\" role=\"none\">\n      <li role=\"none\">\n      <span class=\"tag-pill\">\n        <span class=\"visually-hidden\">Kategorie: <\/span>\n        BMFTR      <\/span>\n    <\/li>\n  <\/ul>      <\/div>\n    \n    <div class=\"teaser-project__body\">\n      <div class=\"teaser-project__title h5\">\n        <a href=\"https:\/\/www.drfz.de\/en\/forschungsprojekte\/german-centre-for-child-and-adolescent-health-dzkj\/\" 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