{"id":3501,"date":"2025-01-21T15:12:10","date_gmt":"2025-01-21T15:12:10","guid":{"rendered":"https:\/\/www.drfz.de\/?post_type=working-group&#038;p=3501"},"modified":"2025-07-30T12:02:17","modified_gmt":"2025-07-30T12:02:17","slug":"chronische-entzundung","status":"publish","type":"working-group","link":"https:\/\/www.drfz.de\/en\/arbeitsgruppen\/chronische-entzundung\/","title":{"rendered":"Chronic Inflammation"},"content":{"rendered":"\n  <section id=\"about-us\"\n           class=\"section accordion  alignwide  toc-item\"\n           data-open=\"multiple\">\n    <div class=\"container container--center container--medium\">\n              <h2 class=\"h3 section__heading launimation slideBottom\">About us<\/h2>\n      \n      \n      \n              <div id=\"panel-\"\n             class=\"accordion__category active\" role=\"tabpanel\"\n             aria-labelledby=\"tab-\">\n                    <script type=\"application\/ld+json\">\n            {\n              \"@context\": \"https:\/\/schema.org\",\n              \"@type\": \"FAQPage\",\n              \"mainEntity\": [{\"@type\": \"Question\",\"name\": \"Role of TNF and IL-22 in tissue regeneration in chronic arthritis \",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"Proinflammatory cytokine production can be influenced by microbiota composition in rheumatic patients. We observed significant changes in microbiota composition in patients with rheumatic diseases, and enhanced capacity of such microbiota to induce Tumor Necrosis Factor (TNF) production from peripheral blood mononuclear cells. TNF blockade in patients leads to significant disease amelioration and tissue repair via poorly understood mechanisms. We have revealed that TNF blocks tissue repair via the downregulation of IL-22 biological activity both in mice and humans. In chronic autoimmune arthritis, we found that TNF is crucial for the regulation of blood monocyte homeostasis via control of T cell responses.\"}},{\"@type\": \"Question\",\"name\": \"Regulation of the intestinal flora through IgA production \",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"Since one of the mechanisms of immune-mediated control of microbiota composition is the production of microbiota-specific IgA antibodies by intestinal plasma B cells, we are currently \u00a0dissecting the mechanisms of microbiota control by IgA and utilisation of these mechanisms for microbiota analysis and modulation. To this end, we have generated a set of microbiota-specific IgA antibodies specific to distinct microbiota species, and have identified several antibodies that bind immunologically relevant bacteria in the microbiota.\nAltogether, our data reveal interplay between microbiota composition, cytokine production and rheumatic diseases manifestation, and provide potential novel strategies for treating rheumatic diseases by modulating intestinal microbiota.\"}}]\n            }\n          <\/script>\n\n          <div class=\"accordion__content\">\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69e8932f15526_0\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">Role of TNF and IL-22 in tissue regeneration in chronic arthritis <\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69e8932f15526_0\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p>Proinflammatory cytokine production can be influenced by microbiota composition in rheumatic patients. We observed significant changes in microbiota composition in patients with rheumatic diseases, and enhanced capacity of such microbiota to induce Tumor Necrosis Factor (TNF) production from peripheral blood mononuclear cells. TNF blockade in patients leads to significant disease amelioration and tissue repair via poorly understood mechanisms. We have revealed that TNF blocks tissue repair via the downregulation of IL-22 biological activity both in mice and humans. In chronic autoimmune arthritis, we found that TNF is crucial for the regulation of blood monocyte homeostasis via control of T cell responses.<\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69e8932f15526_1\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">Regulation of the intestinal flora through IgA production <\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69e8932f15526_1\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p>Since one of the mechanisms of immune-mediated control of microbiota composition is the production of microbiota-specific IgA antibodies by intestinal plasma B cells, we are currently \u00a0dissecting the mechanisms of microbiota control by IgA and utilisation of these mechanisms for microbiota analysis and modulation. To this end, we have generated a set of microbiota-specific IgA antibodies specific to distinct microbiota species, and have identified several antibodies that bind immunologically relevant bacteria in the microbiota.<\/p>\n<p>Altogether, our data reveal interplay between microbiota composition, cytokine production and rheumatic diseases manifestation, and provide potential novel strategies for treating rheumatic diseases by modulating intestinal microbiota.<\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                      <\/div>\n        <\/div>\n          <\/div>\n  <\/section>\n\n\n\n\n  <section id=\"team\"\n           class=\"section accordion  alignwide  toc-item\"\n           data-open=\"multiple\">\n    <div class=\"container container--center container--medium\">\n              <h2 class=\"h3 section__heading launimation slideBottom\">Team<\/h2>\n      \n      \n      \n              <div id=\"panel-\"\n             class=\"accordion__category active\" role=\"tabpanel\"\n             aria-labelledby=\"tab-\">\n                    <script type=\"application\/ld+json\">\n            {\n              \"@context\": \"https:\/\/schema.org\",\n              \"@type\": \"FAQPage\",\n              \"mainEntity\": [{\"@type\": \"Question\",\"name\": \"Members\",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"Group leader\nDr. rer. nat. Andrey Kruglov\nPh.D. Students\nLayal Albdeirat\nMarina Bondareva\nMarjenna Schulte\nSenior Scientific Advisor\nProf. Dr. nat. Fritz Melchers\"}}]\n            }\n          <\/script>\n\n          <div class=\"accordion__content\">\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69e8932f16120_0\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">Members<\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69e8932f16120_0\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p><strong>Group leader<\/strong><br \/>\nDr. rer. nat. Andrey Kruglov<\/p>\n<p><strong>Ph.D. Students<br \/>\n<\/strong>Layal Albdeirat<br \/>\nMarina Bondareva<br \/>\nMarjenna Schulte<\/p>\n<p><strong>Senior Scientific Advisor<\/strong><br \/>\nProf. Dr. nat. Fritz Melchers<\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                      <\/div>\n        <\/div>\n          <\/div>\n  <\/section>\n\n\n\n\n  <section id=\"main-cooperation-partners\"\n           class=\"section accordion  alignwide  toc-item\"\n           data-open=\"multiple\">\n    <div class=\"container container--center container--medium\">\n              <h2 class=\"h3 section__heading launimation slideBottom\">Main cooperation partners<\/h2>\n      \n      \n      \n              <div id=\"panel-\"\n             class=\"accordion__category active\" role=\"tabpanel\"\n             aria-labelledby=\"tab-\">\n                    <script type=\"application\/ld+json\">\n            {\n              \"@context\": \"https:\/\/schema.org\",\n              \"@type\": \"FAQPage\",\n              \"mainEntity\": [{\"@type\": \"Question\",\"name\": \"Within DRFZ\/Charit\u00e9\",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"Dr. Mir-Farzin Mashreghi, Prof. Andreas Radbruch, Prof. Fritz Melchers, Prof. Thomas D\u00f6rner, Prof. Hyun-Dong Chang, Prof. Philipp Enghard, Prof. Tillman Kalinich\nCharite: Prof. Harald Pr\u00fc\u00df, Prof. Britta Siegmund, Prof. Adrian Schreiber, Prof. Friedemann Paul, Prof. Andreas Diefenbach\"}},{\"@type\": \"Question\",\"name\": \"Within Leibniz\",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"DSMZ (Prof. J. Overmann), FMP (Prof. F. Liu)\"}},{\"@type\": \"Question\",\"name\": \"National industry\",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"Miltenyi Biotec GmbH, Biontech GmbH\"}},{\"@type\": \"Question\",\"name\": \"International academia\",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"Prof. Sergei Grivennikov (Los Angeles), Prof. Yolanda Sanz (Valencia, Spain), Dr. Lauren Davey (Canada), Dr. Fatima Perreira (UK), Ravinsh Kumar (UK)\"}},{\"@type\": \"Question\",\"name\": \"International industry\",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"Prof. Sergei Grivennikov (Los Angeles), Prof. Yolanda Sanz (Valencia, Spain), Dr. Lauren Davey (Canada), Dr. Fatima Perreira (UK), Ravinsh Kumar (UK)\"}}]\n            }\n          <\/script>\n\n          <div class=\"accordion__content\">\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69e8932f16e9b_0\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">Within DRFZ\/Charit\u00e9<\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69e8932f16e9b_0\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p>Dr. Mir-Farzin Mashreghi, Prof. Andreas Radbruch, Prof. Fritz Melchers, Prof. Thomas D\u00f6rner, Prof. Hyun-Dong Chang, Prof. Philipp Enghard, Prof. Tillman Kalinich<\/p>\n<p>Charite: Prof. Harald Pr\u00fc\u00df, Prof. Britta Siegmund, Prof. Adrian Schreiber, Prof. Friedemann Paul, Prof. Andreas Diefenbach<\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69e8932f16e9b_1\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">Within Leibniz<\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69e8932f16e9b_1\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p>DSMZ (Prof. J. Overmann), FMP (Prof. F. Liu)<\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69e8932f16e9b_2\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">National industry<\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69e8932f16e9b_2\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p>Miltenyi Biotec GmbH, Biontech GmbH<\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69e8932f16e9b_3\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">International academia<\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69e8932f16e9b_3\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p>Prof. Sergei Grivennikov (Los Angeles), Prof. Yolanda Sanz (Valencia, Spain), Dr. Lauren Davey (Canada), Dr. Fatima Perreira (UK), Ravinsh Kumar (UK)<\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69e8932f16e9b_4\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">International industry<\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69e8932f16e9b_4\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p>Prof. Sergei Grivennikov (Los Angeles), Prof. Yolanda Sanz (Valencia, Spain), Dr. Lauren Davey (Canada), Dr. Fatima Perreira (UK), Ravinsh Kumar (UK)<\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                      <\/div>\n        <\/div>\n          <\/div>\n  <\/section>\n\n\n\n\n  <section id=\"news\"\n           class=\"section related-news alignwide related-news--slider  toc-item\">\n    <div class=\"container container--center\">\n\n      <div class=\"related-news__wrap\">\n                  <div 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Beitrag\" rel=\"bookmark\">\n          KFO 5023 &#8211; BECAUSE-Y        <\/a>\n      <\/div>\n    <\/div>\n  <\/div>\n<\/article>              <\/div>\n                          <div class=\"swiper-slide\">\n                <article\n  id=\"post-4495\" class=\"teaser-project box launimation slideBottom graded-box post-4495 project type-project status-publish hentry programme-area-tax-programme-area-3 supporter-leibniz-association working-group-tax-chronic-inflammation\">\n  <div class=\"teaser-project__wrap\">\n          <div class=\"teaser-project__cats\">\n        \n<ul class=\"tag-pills tag-pills--small\" role=\"none\">\n      <li role=\"none\">\n      <span class=\"tag-pill\">\n        <span class=\"visually-hidden\">Kategorie: <\/span>\n        Leibniz Association      <\/span>\n    <\/li>\n  <\/ul>      <\/div>\n    \n    <div class=\"teaser-project__body\">\n      <div class=\"teaser-project__title h5\">\n        <a href=\"https:\/\/www.drfz.de\/en\/forschungsprojekte\/imprinting-of-adaptive-immunity-by-cross-reactivity\/\" aria-describedby=\"post-4495\"\n          title=\"Gehe zum Beitrag\" rel=\"bookmark\">\n          Imprinting of Adaptive Immunity by Cross-Reactivity (ImpACt)        <\/a>\n      <\/div>\n    <\/div>\n  <\/div>\n<\/article>              <\/div>\n                          <div class=\"swiper-slide\">\n                <article\n  id=\"post-4114\" class=\"teaser-project box launimation slideBottom graded-box post-4114 project type-project status-publish hentry programme-area-tax-programme-area-1 programme-area-tax-programme-area-3 programme-area-tax-programme-area-4 supporter-dfg-en working-group-tax-cell-biology working-group-tax-chronic-inflammation working-group-tax-developmental-and-mucosal-immunology working-group-tax-inflammatory-mechanisms working-group-tax-innate-immunity working-group-tax-macrophage-biology-and-innate-cellular-networks-in-chronic-inflammatory-diseases working-group-tax-schwiete-lab-for-microbiota-and-inflammation-en\">\n  <div class=\"teaser-project__wrap\">\n          <div class=\"teaser-project__cats\">\n        \n<ul class=\"tag-pills tag-pills--small\" role=\"none\">\n      <li role=\"none\">\n      <span class=\"tag-pill\">\n        <span class=\"visually-hidden\">Kategorie: <\/span>\n        DFG      <\/span>\n    <\/li>\n  <\/ul>      <\/div>\n    \n    <div class=\"teaser-project__body\">\n      <div class=\"teaser-project__title h5\">\n        <a href=\"https:\/\/www.drfz.de\/en\/forschungsprojekte\/dfg-sfb-trr-241\/\" aria-describedby=\"post-4114\"\n          title=\"Gehe zum Beitrag\" rel=\"bookmark\">\n          DFG CRC TRR 241 &#8211; Immune-Epithelial Communication in Inflammatory Bowel Diseases        <\/a>\n      <\/div>\n    <\/div>\n  <\/div>\n<\/article>              <\/div>\n            \n          <\/div><!-- swiper-wrapper -->\n\n                      <div class=\"slider__pagination 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","protected":false},"excerpt":{"rendered":"","protected":false},"author":4,"featured_media":20229,"template":"","programme-area-tax":[181],"working-group-tag":[323,346,333],"working-group-tax":[243],"class_list":["post-3501","working-group","type-working-group","status-publish","has-post-thumbnail","hentry","programme-area-tax-programme-area-3","working-group-tag-chronic-arthritis","working-group-tag-microbiota-en","working-group-tag-tissue-regeneration-en","working-group-tax-chronic-inflammation"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Chronic Inflammation - DRFZ<\/title>\n<meta name=\"description\" content=\"Andrey Kruglov heads the research group Chronic Inflammation at the German Rheumatology Research Center, a Leibniz Institute.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link 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