{"id":3503,"date":"2025-01-21T15:05:37","date_gmt":"2025-01-21T15:05:37","guid":{"rendered":"https:\/\/www.drfz.de\/?post_type=working-group&#038;p=3503"},"modified":"2025-07-30T12:05:05","modified_gmt":"2025-07-30T12:05:05","slug":"chronische-entzundungen-im-kindesalter","status":"publish","type":"working-group","link":"https:\/\/www.drfz.de\/en\/arbeitsgruppen\/chronische-entzundungen-im-kindesalter\/","title":{"rendered":"Chronic inflammation in childhood"},"content":{"rendered":"\n  <section id=\"about-us\"\n           class=\"section accordion  alignwide  toc-item\"\n           data-open=\"multiple\">\n    <div class=\"container container--center container--medium\">\n              <h2 class=\"h3 section__heading launimation slideBottom\">About us<\/h2>\n      \n      \n      \n              <div id=\"panel-\"\n             class=\"accordion__category active\" role=\"tabpanel\"\n             aria-labelledby=\"tab-\">\n                    <script type=\"application\/ld+json\">\n            {\n              \"@context\": \"https:\/\/schema.org\",\n              \"@type\": \"FAQPage\",\n              \"mainEntity\": [{\"@type\": \"Question\",\"name\": \"Molecular immune cells signatures \",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"In cooperation with the research group of Mir-Farzin Mashreghi, we aim to define molecular immune cell signatures in the inflamed synovia and in the peripheral blood of children suffering from different forms of JIA. With these results we will define markers specific for the different forms of JIA which can be traced in peripheral blood. Using data from newly established cohorts, we aim to analyze the suitability of these tools to classify the disease, monitor the disease activity and finally to predict the response to different therapeutic regimens. This translational approach will help to establish JIA-specific endotypes, which are fundamental for the development of personalised treatment strategies.\"}},{\"@type\": \"Question\",\"name\": \"Monogenic autoinflammatory diseases\",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"Monogenic alterations causing systemic inflammatory diseases usually manifest in early childhood. They are characterized by excessive production of pro-inflammatory cytokines and are referred to as autoinflammatory diseases (AID). In the last decade, analysis of these underlying molecular genetic alterations has uncovered new immunological pathomechanisms, e.g. the dysregulation of the inflammasome reaction. Analyzing our cohort of patients with defined, (e.g. interferonopathies, inflammasomopathies) as well as unassigned AID, we aim to comprehensively immunophenotype different immune cell populations in order to develop diagnostic markers and unravel the pathological processes leading to excessive cytokine production.\"}}]\n            }\n          <\/script>\n\n          <div class=\"accordion__content\">\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69d75f3f45bf3_0\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">Molecular immune cells signatures <\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69d75f3f45bf3_0\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p>In cooperation with the research group of Mir-Farzin Mashreghi, we aim to define molecular immune cell signatures in the inflamed synovia and in the peripheral blood of children suffering from different forms of JIA. With these results we will define markers specific for the different forms of JIA which can be traced in peripheral blood. Using data from newly established cohorts, we aim to analyze the suitability of these tools to classify the disease, monitor the disease activity and finally to predict the response to different therapeutic regimens. This translational approach will help to establish JIA-specific endotypes, which are fundamental for the development of personalised treatment strategies.<\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69d75f3f45bf3_1\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">Monogenic autoinflammatory diseases<\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69d75f3f45bf3_1\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p>Monogenic alterations causing systemic inflammatory diseases usually manifest in early childhood. They are characterized by excessive production of pro-inflammatory cytokines and are referred to as autoinflammatory diseases (AID). In the last decade, analysis of these underlying molecular genetic alterations has uncovered new immunological pathomechanisms, e.g. the dysregulation of the inflammasome reaction. Analyzing our cohort of patients with defined, (e.g. interferonopathies, inflammasomopathies) as well as unassigned AID, we aim to comprehensively immunophenotype different immune cell populations in order to develop diagnostic markers and unravel the pathological processes leading to excessive cytokine production.<\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                      <\/div>\n        <\/div>\n          <\/div>\n  <\/section>\n\n\n\n\n  <section id=\"team\"\n           class=\"section accordion  alignwide  toc-item\"\n           data-open=\"multiple\">\n    <div class=\"container container--center container--medium\">\n              <h2 class=\"h3 section__heading launimation slideBottom\">Team<\/h2>\n      \n      \n      \n              <div id=\"panel-\"\n             class=\"accordion__category active\" role=\"tabpanel\"\n             aria-labelledby=\"tab-\">\n                    <script type=\"application\/ld+json\">\n            {\n              \"@context\": \"https:\/\/schema.org\",\n              \"@type\": \"FAQPage\",\n              \"mainEntity\": [{\"@type\": \"Question\",\"name\": \"Members\",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"Group leader\nProf. Dr. med. Tilmann Kallinich\nScientists\nDr. med. Carl G\u00f6tzke\nDr. med. Lisa Ehlers\nStudy coordinators\nLena Frey\nStudy physicians\nDr. Sae-Lim von Stuckrad\nDr. Mareike Lieber\nElisabeth Rolfes\nDaiva Gorcyzca\nPh.D. students\nKatharina Bienioschek\nAntje Bjelde\nBengue Sahin\"}}]\n            }\n          <\/script>\n\n          <div class=\"accordion__content\">\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69d75f3f467ad_0\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">Members<\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69d75f3f467ad_0\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p><strong>Group leader<\/strong><br \/>\nProf. Dr. med. Tilmann Kallinich<\/p>\n<p><strong>Scientists<\/strong><br \/>\nDr. med. Carl G\u00f6tzke<br \/>\nDr. med. Lisa Ehlers<\/p>\n<p><strong>Study coordinators<\/strong><br \/>\nLena Frey<\/p>\n<p><strong>Study physicians<\/strong><br \/>\nDr. Sae-Lim von Stuckrad<br \/>\nDr. Mareike Lieber<br \/>\nElisabeth Rolfes<br \/>\nDaiva Gorcyzca<\/p>\n<p><strong>Ph.D. students<br \/>\n<\/strong>Katharina Bienioschek<br \/>\nAntje Bjelde<br \/>\nBengue Sahin<\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                      <\/div>\n        <\/div>\n          <\/div>\n  <\/section>\n\n\n\n\n  <section id=\"main-cooperation-partners\"\n           class=\"section accordion  alignwide  toc-item\"\n           data-open=\"multiple\">\n    <div class=\"container container--center container--medium\">\n              <h2 class=\"h3 section__heading launimation slideBottom\">Main cooperation partners<\/h2>\n      \n      \n      \n              <div id=\"panel-\"\n             class=\"accordion__category active\" role=\"tabpanel\"\n             aria-labelledby=\"tab-\">\n                    <script type=\"application\/ld+json\">\n            {\n              \"@context\": \"https:\/\/schema.org\",\n              \"@type\": \"FAQPage\",\n              \"mainEntity\": [{\"@type\": \"Question\",\"name\": \"Within DRFZ\/Charit\u00e9\",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"MF Mashreghi (DRFZ), A Kruglow (DRFZ), HD Chang (DRFZ), E. Latz (DRFZ), V Sunkaya (DRFZ), K Minden (DRFZ), MA Mall (Charit\u00e9), H von Bernuth (Charit\u00e9), C Romagnani (Charit\u00e9), A Diefenbach (Charit\u00e9)\"}},{\"@type\": \"Question\",\"name\": \"National academia\",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"D Foell (Muenster), MA Lee-Kirsch (Dresden), C. Schuetz (Dresden), K Tenbrock (Aachen)\"}},{\"@type\": \"Question\",\"name\": \"National industry\",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"Involvement in trial performance with Novartis, Lilly, Pfizer\"}},{\"@type\": \"Question\",\"name\": \"International academia\",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"Involvement in trial performance with Novartis, Lilly, Pfizer\"}}]\n            }\n          <\/script>\n\n          <div class=\"accordion__content\">\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69d75f3f47536_0\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">Within DRFZ\/Charit\u00e9<\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69d75f3f47536_0\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p>MF Mashreghi (DRFZ), A Kruglow (DRFZ), HD Chang (DRFZ), E. Latz (DRFZ), V Sunkaya (DRFZ), K Minden (DRFZ), MA Mall (Charit\u00e9), H von Bernuth (Charit\u00e9), C Romagnani (Charit\u00e9), A Diefenbach (Charit\u00e9)<\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69d75f3f47536_1\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">National academia<\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69d75f3f47536_1\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p>D Foell (Muenster), MA Lee-Kirsch (Dresden), C. Schuetz (Dresden), K Tenbrock (Aachen)<\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69d75f3f47536_2\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">National industry<\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69d75f3f47536_2\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p>Involvement in trial performance with Novartis, Lilly, Pfizer<\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69d75f3f47536_3\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">International academia<\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69d75f3f47536_3\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p>Involvement in trial performance with Novartis, Lilly, Pfizer<\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                      <\/div>\n        <\/div>\n          <\/div>\n  <\/section>\n\n\n\n\n  <section id=\"ebv-reactivation-as-a-key-mechanism-of-mis-c-after-sars-cov-2-infection\"    class=\"section featured-post alignwide bg bg--full-width bg--aqua-100\">\n    <div class=\"container container--center\">\n      <div class=\"featured-post__container\">\n        <div class=\"featured-post__content launimation slideBottom\">\n                      <div class=\"featured-post__info\">\n                              \n<ul class=\"tag-pills\" >\n      <li >\n      <span class=\"tag-pill\">\n        <span class=\"visually-hidden\">Kategorie: <\/span>\n        For patients      <\/span>\n    <\/li>\n      <li >\n      <span class=\"tag-pill\">\n        <span class=\"visually-hidden\">Kategorie: <\/span>\n        Publications      <\/span>\n    <\/li>\n  <\/ul>                                                          <time class=\"featured-post__date date\" datetime=\"2025-03-07 15:00:12\">07.03.2025<\/time>                          <\/div>\n                                <h2 class=\"featured-post__title h2\" lang=\"en          \">EBV reactivation as a key mechanism of MIS-C after SARS-CoV-2 infection<\/h2>\n          \n                      <p class=\"featured-post__text\">Why children become seriously ill weeks after a Covid-19 infection and how they can be cured Researchers from Dr. Mir-Farzin Mashreghi\u2019s group from the German\u2026<\/p>\n          \n          <a class=\"featured-post__button button button--arrow button--arrow-link\"\n            href=\"https:\/\/www.drfz.de\/en\/neuigkeiten\/ebv-reactivation-as-a-key-mechanism-of-mis-c-after-sars-cov-2-infection\/\"><span\n              class=\"visually-hidden\">EBV reactivation as a key mechanism of MIS-C after SARS-CoV-2 infection<\/span><\/a>\n        <\/div>\n                  <div class=\"featured-post__media launimation slideRight\">\n            <img loading=\"lazy\" decoding=\"async\" sizes=\"auto, 624px\" src=\"https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/03\/25_03_12_EBV-Reaktivierung-als-Schluesselmechanismus_03-1024x614.jpg\" srcset=\"https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/03\/25_03_12_EBV-Reaktivierung-als-Schluesselmechanismus_03-1920x1152.jpg 1920w, https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/03\/25_03_12_EBV-Reaktivierung-als-Schluesselmechanismus_03-1600x960.jpg 1600w, https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/03\/25_03_12_EBV-Reaktivierung-als-Schluesselmechanismus_03-1366x820.jpg 1366w, https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/03\/25_03_12_EBV-Reaktivierung-als-Schluesselmechanismus_03-1024x614.jpg 1024w, https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/03\/25_03_12_EBV-Reaktivierung-als-Schluesselmechanismus_03-768x461.jpg 768w, https:\/\/www.drfz.de\/wp-content\/uploads\/2025\/03\/25_03_12_EBV-Reaktivierung-als-Schluesselmechanismus_03-550x330.jpg 550w\" class=\"\" alt=\"EBV-Reaktivierung als Schl\u00fcsselmechanismus\"  width=\"1024\"  height=\"614\">          <\/div>\n              <\/div>\n    <\/div>\n  <\/section>\n\n\n\n  <section id=\"news\"\n           class=\"section related-news alignwide related-news--slider  toc-item\">\n    <div class=\"container container--center\">\n\n      <div class=\"related-news__wrap\">\n                  <div class=\"section__heading-container launimation slideBottom\">\n                          <h2 class=\"section__heading\">News<\/h2>\n                                  <\/div>\n        \n        \n        <div 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tag-pills--small\" role=\"none\">\n      <li role=\"none\">\n      <span class=\"tag-pill\">\n        <span class=\"visually-hidden\">Kategorie: <\/span>\n        For patients      <\/span>\n    <\/li>\n  <\/ul>    <\/div>\n\n    <div class=\"teaser-post__body\">\n      <time class=\"date\" datetime=\"2025-11-10 16:00:20\">10.11.2025<\/time>\n      <div class=\"teaser-post__title h5\">\n        <a href=\"https:\/\/www.drfz.de\/en\/neuigkeiten\/on-the-trail-of-a-mysterious-childhood-disease-the-story-of-ace-and-research-into-pims\/\" aria-describedby=\"post-20167\"\n          title=\"Gehe zum Beitrag\" rel=\"bookmark\">\n          On the trail of a mysterious childhood disease\u2014The story of Ace and research into PIMS        <\/a>\n      <\/div>\n\n              <div class=\"teaser-post__excerpt ellipsis\">\n          Tilmann Kallinich and Mir-Farzin Mashreghi in Leibniz Magazine In Leibniz Magazine, Fabian Zapatka tells the story of six-year-old Ace Jaite, representing many children with Pediatric\u2026        <\/div>\n          <\/div>\n  <\/div>\n<\/article>              <\/div>\n                          <div class=\"swiper-slide\">\n                \n<article\n  id=\"post-19854\" class=\"teaser-post box box--min-height launimation slideBottom graded-box post-19854 post type-post status-publish format-standard has-post-thumbnail hentry category-for-patients category-news-en tag-chronic-inflammatory-diseases-of-childhood-adolescence tag-program-area-3 tag-therapeutic-gene-regulation\">\n  <div class=\"teaser-post__wrap\">\n    <div class=\"teaser-post__cats\">\n      \n<ul class=\"tag-pills tag-pills--small\" role=\"none\">\n      <li role=\"none\">\n      <span class=\"tag-pill\">\n        <span class=\"visually-hidden\">Kategorie: <\/span>\n        For patients      <\/span>\n    <\/li>\n  <\/ul>    <\/div>\n\n    <div class=\"teaser-post__body\">\n      <time class=\"date\" datetime=\"2025-09-30 15:18:49\">30.09.2025<\/time>\n      <div 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rel=\"bookmark\">\n          Awards at the DGRh Congress 2025        <\/a>\n      <\/div>\n\n              <div class=\"teaser-post__excerpt ellipsis\">\n          Julia Rautenstrauch, Jacob Ritter, and Lisa Lindner honored during the 2025 Rheumatology Congress The 53rd Congress of the German Society for Rheumatology and Clinical Immunology\u2026        <\/div>\n          <\/div>\n  <\/div>\n<\/article>              <\/div>\n            \n          <\/div><!-- swiper-wrapper -->\n\n                      <div class=\"slider__pagination slider__pagination--contained\">\n              <button class=\"slider__button-prev\"><\/button>\n              <button class=\"slider__button-next\"><\/button>\n            <\/div>\n          \n                      <div class=\"slider__skip-links-container\">\n              <a id=\"after-slider-block_bca04c814e79f8b419d781ba5a513e9f\"\n                 href=\"#before-slider-block_bca04c814e79f8b419d781ba5a513e9f\"\n                 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