{"id":3509,"date":"2025-01-21T14:50:42","date_gmt":"2025-01-21T14:50:42","guid":{"rendered":"https:\/\/www.drfz.de\/?post_type=working-group&#038;p=3509"},"modified":"2025-07-30T12:55:59","modified_gmt":"2025-07-30T12:55:59","slug":"zellbiologie","status":"publish","type":"working-group","link":"https:\/\/www.drfz.de\/en\/arbeitsgruppen\/zellbiologie\/","title":{"rendered":"Cell Biology"},"content":{"rendered":"\n  <section id=\"about-us\"\n           class=\"section accordion  alignwide  toc-item\"\n           data-open=\"multiple\">\n    <div class=\"container container--center container--medium\">\n              <h2 class=\"h3 section__heading launimation slideBottom\">About us<\/h2>\n      \n      \n      \n              <div id=\"panel-\"\n             class=\"accordion__category active\" role=\"tabpanel\"\n             aria-labelledby=\"tab-\">\n                    <script type=\"application\/ld+json\">\n            {\n              \"@context\": \"https:\/\/schema.org\",\n              \"@type\": \"FAQPage\",\n              \"mainEntity\": [{\"@type\": \"Question\",\"name\": \"From acute to chronic inflammation\",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"An indication of how (rheumatic) chronic inflammation can initiate is provided by the severe disease course in COVID-19 patients who require intensive, prolonged medical care. In collaboration with the research group Mashreghi, we have studied the immune response of these patients over time. The early acute immune reaction induced by the SARS-CoV-2 virus is directed against the virus. However, later the immune reaction is no longer directed against the virus, rather against the patient\u2019s own body. When memory lymphocytes are formed in this immune reaction, the inflammation becomes chronic, and it will no longer respond to therapies that suppress acute immune reactions.\"}},{\"@type\": \"Question\",\"name\": \"Memory plasma lymphocytes\",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"Our group discovered some time ago memory plasma cells, which as we have shown in collaboration with the research group of Falk Hiepe, play a central role in chronic inflammations caused by antibodies, e.g. in systemic lupus erythematosus (SLE). Patients with such pathogenic memory plasma cells cannot achieve therapy-free remission, i.e. be cured, at best their disease symptoms can be suppressed. \u00a0These memory plasma cells are refractory to conventional therapies and continue to secrete their disease-driving antibodies undeterred. We are looking for novel approaches to target these cells therapeutically, from a basic understanding of how and where these cells survive in the body. We have shown that memory plasma cells are mainly located in the bone marrow and in inflamed tissues, where they attach to certain connective tissue cells. And we have shown that the plasma cells need contact with these stromal connective tissue cells to survive. Now we are deciphering the molecular code of the synapse between both cells, and how this translates into survival for different types of plasma cells, protective and pathogenic ones. For the first time, this may open up options for selectively eliminating pathogenic plasma cells, and ablating the cells causing chronic rheumatic inflammation driven by antibodies.\"}},{\"@type\": \"Question\",\"name\": \"Memory B lymphocytes\",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"The precursors of memory plasma cells are memory B lymphocytes, which also control chronic inflammation themselves, together with memory T lymphocytes. Unexpectedly for the experts, we have now been able to show for the first time that most memory B lymphocytes, similar to memory plasma cells, are found in the bone marrow, where they also attach to connective tissue cells and do not circulate through the body via blood. We suspect that they are also maintained and survive in a similar way to plasma cells and are therefore resistant to conventional therapies. Even more surprising is that we could identify many different types of memory B lymphocytes. We are now investigating whether the pathogenic B lymphocytes in arthritis patients belong to a particular subset, which would enable us to target them selectively.\"}},{\"@type\": \"Question\",\"name\": \"Memory T lymphocytes\",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"Together with memory B lymphocytes, memory T lymphocytes control immune reactions, especially the development of memory plasma cells, but also cytokine-mediated chronic inflammation, independent of antibodies. We were able to demonstrate this in Juvenile Idiopathic Arthritis (JIA): a type of arthritis affecting children. We detect these harmful memory T-lymphocytes mainly in the inflamed tissue itself, e.g. in the inflamed joints, where they actively control the chronic inflammation by secretion of cytokines, alarming other cells, and chemokines, attracting and activating effector cells. In order to survive in the joints, the memory T lymphocytes have to adapt to the inflammatory environment. We have identified genes that enable this adaptation, such as the transcription factor TWIST1 and the microRNA miR-148a. We could show that TWIST1 adapts the metabolism of the cells to the environment of the inflamed tissue and prevents death of the cells by switching on miR-148a, and antagonist of the pro-apoptotic gene BCL-2. In a mouse model of intestinal inflammation, we have already been able to selectively kill the harmful memory T lymphocytes in the animals, with \u201cantagomirs\u201d blocking mir-148a, without targeting protective memory T lymphocytes. This is the first indication that it is indeed possible to therapeutically ablate pathogenic memory T lymphocytes in a targeted manner.\"}}]\n            }\n          <\/script>\n\n          <div class=\"accordion__content\">\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69d85ea54cf44_0\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">From acute to chronic inflammation<\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69d85ea54cf44_0\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p>An indication of how (rheumatic) chronic inflammation can initiate is provided by the severe disease course in COVID-19 patients who require intensive, prolonged medical care. In collaboration with the research group Mashreghi, we have studied the immune response of these patients over time. The early acute immune reaction induced by the SARS-CoV-2 virus is directed against the virus. However, later the immune reaction is no longer directed against the virus, rather against the patient\u2019s own body. When memory lymphocytes are formed in this immune reaction, the inflammation becomes chronic, and it will no longer respond to therapies that suppress acute immune reactions.<\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69d85ea54cf44_1\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">Memory plasma lymphocytes<\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69d85ea54cf44_1\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p>Our group discovered some time ago memory plasma cells, which as we have shown in collaboration with the research group of Falk Hiepe, play a central role in chronic inflammations caused by antibodies, e.g. in systemic lupus erythematosus (SLE). Patients with such pathogenic memory plasma cells cannot achieve therapy-free remission, i.e. be cured, at best their disease symptoms can be suppressed. \u00a0These memory plasma cells are refractory to conventional therapies and continue to secrete their disease-driving antibodies undeterred. We are looking for novel approaches to target these cells therapeutically, from a basic understanding of how and where these cells survive in the body. We have shown that memory plasma cells are mainly located in the bone marrow and in inflamed tissues, where they attach to certain connective tissue cells. And we have shown that the plasma cells need contact with these stromal connective tissue cells to survive. Now we are deciphering the molecular code of the synapse between both cells, and how this translates into survival for different types of plasma cells, protective and pathogenic ones. For the first time, this may open up options for selectively eliminating pathogenic plasma cells, and ablating the cells causing chronic rheumatic inflammation driven by antibodies.<\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69d85ea54cf44_2\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">Memory B lymphocytes<\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69d85ea54cf44_2\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p>The precursors of memory plasma cells are memory B lymphocytes, which also control chronic inflammation themselves, together with memory T lymphocytes. Unexpectedly for the experts, we have now been able to show for the first time that most memory B lymphocytes, similar to memory plasma cells, are found in the bone marrow, where they also attach to connective tissue cells and do not circulate through the body via blood. We suspect that they are also maintained and survive in a similar way to plasma cells and are therefore resistant to conventional therapies. Even more surprising is that we could identify many different types of memory B lymphocytes. We are now investigating whether the pathogenic B lymphocytes in arthritis patients belong to a particular subset, which would enable us to target them selectively.<\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69d85ea54cf44_3\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">Memory T lymphocytes<\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69d85ea54cf44_3\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p>Together with memory B lymphocytes, memory T lymphocytes control immune reactions, especially the development of memory plasma cells, but also cytokine-mediated chronic inflammation, independent of antibodies. We were able to demonstrate this in Juvenile Idiopathic Arthritis (JIA): a type of arthritis affecting children. We detect these harmful memory T-lymphocytes mainly in the inflamed tissue itself, e.g. in the inflamed joints, where they actively control the chronic inflammation by secretion of cytokines, alarming other cells, and chemokines, attracting and activating effector cells. In order to survive in the joints, the memory T lymphocytes have to adapt to the inflammatory environment. We have identified genes that enable this adaptation, such as the transcription factor TWIST1 and the microRNA miR-148a. We could show that TWIST1 adapts the metabolism of the cells to the environment of the inflamed tissue and prevents death of the cells by switching on miR-148a, and antagonist of the pro-apoptotic gene BCL-2. In a mouse model of intestinal inflammation, we have already been able to selectively kill the harmful memory T lymphocytes in the animals, with \u201cantagomirs\u201d blocking mir-148a, without targeting protective memory T lymphocytes. This is the first indication that it is indeed possible to therapeutically ablate pathogenic memory T lymphocytes in a targeted manner.<\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                      <\/div>\n        <\/div>\n          <\/div>\n  <\/section>\n\n\n\n\n  <section id=\"team\"\n           class=\"section accordion  alignwide  toc-item\"\n           data-open=\"multiple\">\n    <div class=\"container container--center container--medium\">\n              <h2 class=\"h3 section__heading launimation slideBottom\">Team<\/h2>\n      \n      \n      \n              <div id=\"panel-\"\n             class=\"accordion__category active\" role=\"tabpanel\"\n             aria-labelledby=\"tab-\">\n                    <script type=\"application\/ld+json\">\n            {\n              \"@context\": \"https:\/\/schema.org\",\n              \"@type\": \"FAQPage\",\n              \"mainEntity\": [{\"@type\": \"Question\",\"name\": \"Members\",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"Group leader\nProf. Dr. rer. nat Andreas Radbruch\nScientists\nJun Dong, PhD\nPhD students\nXiangyi Deng\nLukas Heiberger\nJinchan Li\nPedram Mahmoudi\nEmilia Schneider\nYu Shen\nZixu Wang\"}}]\n            }\n          <\/script>\n\n          <div class=\"accordion__content\">\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69d85ea54d881_0\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">Members<\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69d85ea54d881_0\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      \n\n\n\n\n<p><strong>Group leader<\/strong><br \/>\nProf. Dr. rer. nat Andreas Radbruch<\/p>\n<p><strong>Scientists<br \/>\n<\/strong>Jun Dong, PhD<\/p>\n<p><strong>PhD students<br \/>\n<\/strong>Xiangyi Deng<br \/>\nLukas Heiberger<br \/>\nJinchan Li<br \/>\nPedram Mahmoudi<br \/>\nEmilia Schneider<br \/>\nYu Shen<br \/>\nZixu Wang<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                      <\/div>\n        <\/div>\n          <\/div>\n  <\/section>\n\n\n\n\n  <section id=\"news\"\n           class=\"section related-news alignwide related-news--slider  toc-item\">\n    <div class=\"container container--center\">\n\n      <div class=\"related-news__wrap\">\n                  <div class=\"section__heading-container launimation slideBottom\">\n                          <h2 class=\"section__heading\">News<\/h2>\n                                  <\/div>\n        \n        \n        <div class=\"related-news__slider swiper swiper-pull-right\">\n                      <div class=\"slider__skip-links-container\">\n              <a id=\"before-slider-block_cda11cc029c48df8fcf9f23785dd8d2b\"\n                 href=\"#after-slider-block_cda11cc029c48df8fcf9f23785dd8d2b\"\n                 class=\"slider-skip-link\">Go to end of slider<\/a>\n            <\/div>\n          \n          <div class=\"swiper-wrapper grid graded-boxes\">\n                          <div class=\"swiper-slide\">\n                \n<article\n  id=\"post-17747\" class=\"teaser-post box box--min-height launimation slideBottom graded-box post-17747 post type-post status-publish format-standard has-post-thumbnail hentry category-news-en category-publications tag-andreas-radbruch-en tag-cell-biology tag-program-area-1 tag-radbruch-en working-group-tax-cell-biology\">\n  <div class=\"teaser-post__wrap\">\n    <div class=\"teaser-post__cats\">\n      \n<ul class=\"tag-pills tag-pills--small\" role=\"none\">\n      <li role=\"none\">\n      <span class=\"tag-pill\">\n        <span class=\"visually-hidden\">Kategorie: <\/span>\n        News      <\/span>\n    <\/li>\n  <\/ul>    <\/div>\n\n    <div class=\"teaser-post__body\">\n      <time class=\"date\" datetime=\"2025-06-04 07:28:11\">04.06.2025<\/time>\n      <div class=\"teaser-post__title h5\">\n        <a href=\"https:\/\/www.drfz.de\/en\/neuigkeiten\/revisiting-tissue-residency-cd69%e2%81%bb-memory-t-cells-in-the-human-bone-marrow\/\" aria-describedby=\"post-17747\"\n          title=\"Gehe zum Beitrag\" rel=\"bookmark\">\n          Revisiting Tissue Residency: CD69\u207b Memory T Cells in the Human Bone Marrow        <\/a>\n      <\/div>\n\n              <div class=\"teaser-post__excerpt ellipsis\">\n          Retention of Surface CD69-Negative Memory T Cells in Bone Marrow via S1PR1 Internalization Tissue-resident memory T cells play a central role in inflammatory rheumatic diseases,\u2026        <\/div>\n          <\/div>\n  <\/div>\n<\/article>              <\/div>\n                          <div class=\"swiper-slide\">\n                \n<article\n  id=\"post-8484\" class=\"teaser-post box box--min-height launimation slideBottom graded-box post-8484 post type-post status-publish format-standard has-post-thumbnail hentry category-publications tag-b-cell-memory tag-cell-biology tag-thomas-doerner-en tag-mashreghi-en tag-program-area-1 tag-program-area-3 tag-program-area-4 tag-radbruch-en tag-therapeutic-gene-regulation programme-area-tax-programme-area-1 programme-area-tax-programme-area-3 programme-area-tax-programme-area-4 working-group-tax-b-cell-memory working-group-tax-cell-biology working-group-tax-therapeutic-gene-regulation\">\n  <div class=\"teaser-post__wrap\">\n    <div class=\"teaser-post__cats\">\n      \n<ul class=\"tag-pills tag-pills--small\" role=\"none\">\n      <li role=\"none\">\n      <span class=\"tag-pill\">\n        <span class=\"visually-hidden\">Kategorie: <\/span>\n        Publications      <\/span>\n    <\/li>\n  <\/ul>    <\/div>\n\n    <div class=\"teaser-post__body\">\n      <time class=\"date\" datetime=\"2024-05-22 14:07:00\">22.05.2024<\/time>\n      <div class=\"teaser-post__title h5\">\n        <a href=\"https:\/\/www.drfz.de\/en\/neuigkeiten\/schluesselerkenntnisse-ueber-plasmazellen-des-knochenmarks-und-langanhaltende-immunitaet\/\" aria-describedby=\"post-8484\"\n          title=\"Gehe zum Beitrag\" rel=\"bookmark\">\n          Key Insights into Bone Marrow Plasma Cells and Long-Lasting Immunity        <\/a>\n      <\/div>\n\n              <div class=\"teaser-post__excerpt ellipsis\">\n          A groundbreaking study conducted by researchers from the German Rheumatology Research Centre Berlin, an institute of the Leibniz Association, and the Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin\u2026        <\/div>\n          <\/div>\n  <\/div>\n<\/article>              <\/div>\n                          <div class=\"swiper-slide\">\n                \n<article\n  id=\"post-13048\" class=\"teaser-post box box--min-height launimation slideBottom graded-box post-13048 post type-post status-publish format-standard has-post-thumbnail hentry category-for-patients tag-cell-biology tag-program-area-1 tag-radbruch-en programme-area-tax-programme-area-1 working-group-tax-cell-biology\">\n  <div class=\"teaser-post__wrap\">\n    <div class=\"teaser-post__cats\">\n      \n<ul class=\"tag-pills tag-pills--small\" role=\"none\">\n      <li role=\"none\">\n      <span class=\"tag-pill\">\n        <span class=\"visually-hidden\">Kategorie: <\/span>\n        For patients      <\/span>\n    <\/li>\n  <\/ul>    <\/div>\n\n    <div class=\"teaser-post__body\">\n      <time class=\"date\" datetime=\"2023-11-30 08:54:00\">30.11.2023<\/time>\n      <div class=\"teaser-post__title h5\">\n        <a href=\"https:\/\/www.drfz.de\/en\/neuigkeiten\/portrait-von-andreas-radbruch-im-leibniz-magazin\/\" aria-describedby=\"post-13048\"\n          title=\"Gehe zum Beitrag\" rel=\"bookmark\">\n          Portrait of Andreas Radbruch in Leibniz Magazine        <\/a>\n      <\/div>\n\n              <div class=\"teaser-post__excerpt ellipsis\">\n          The Leibniz Magazine has published a portrait of Andreas Radbruch, head of the \u201cCell Biology\u201d group at the DRFZ, in the issue focusing on \u201cMemory\u201d.\u2026        <\/div>\n          <\/div>\n  <\/div>\n<\/article>              <\/div>\n            \n          <\/div><!-- swiper-wrapper -->\n\n                      <div class=\"slider__pagination slider__pagination--contained\">\n              <button 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      \n        <div class=\"related-projects__slider swiper swiper-pull-right\">\n                      <div class=\"slider__skip-links-container\">\n              <a id=\"before-slider-block_7976c5af70b7f6fd0a29676d55cf1ee4\"\n                 href=\"#after-slider-block_7976c5af70b7f6fd0a29676d55cf1ee4\"\n                 class=\"slider-skip-link\">Go to end of slider<\/a>\n            <\/div>\n          \n          <div class=\"swiper-wrapper grid graded-boxes\">\n                          <div class=\"swiper-slide\">\n                <article\n  id=\"post-15574\" class=\"teaser-project box launimation slideBottom graded-box post-15574 project type-project status-publish hentry programme-area-tax-programme-area-1 programme-area-tax-programme-area-3 supporter-leibniz-association working-group-tax-cell-biology working-group-tax-therapeutic-gene-regulation\">\n  <div class=\"teaser-project__wrap\">\n          <div class=\"teaser-project__cats\">\n        \n<ul class=\"tag-pills tag-pills--small\" role=\"none\">\n      <li role=\"none\">\n      <span class=\"tag-pill\">\n        <span class=\"visually-hidden\">Kategorie: <\/span>\n        Leibniz Association      <\/span>\n    <\/li>\n  <\/ul>      <\/div>\n    \n    <div class=\"teaser-project__body\">\n      <div class=\"teaser-project__title h5\">\n        <a href=\"https:\/\/www.drfz.de\/en\/forschungsprojekte\/leibniz-lab-pandemic-preparedness\/\" aria-describedby=\"post-15574\"\n          title=\"Gehe zum Beitrag\" rel=\"bookmark\">\n          Leibniz-Lab: Pandemic Preparedness        <\/a>\n      <\/div>\n    <\/div>\n  <\/div>\n<\/article>              <\/div>\n                          <div class=\"swiper-slide\">\n                <article\n  id=\"post-4515\" class=\"teaser-project box launimation slideBottom graded-box post-4515 project type-project status-publish hentry programme-area-tax-programme-area-1 programme-area-tax-programme-area-4 supporter-european-union working-group-tax-autoimmunology working-group-tax-cell-biology working-group-tax-schwiete-lab-for-microbiota-and-inflammation-en\">\n  <div class=\"teaser-project__wrap\">\n          <div class=\"teaser-project__cats\">\n        \n<ul class=\"tag-pills tag-pills--small\" role=\"none\">\n      <li role=\"none\">\n      <span class=\"tag-pill\">\n        <span class=\"visually-hidden\">Kategorie: <\/span>\n        European Union      <\/span>\n    <\/li>\n  <\/ul>      <\/div>\n    \n    <div class=\"teaser-project__body\">\n      <div class=\"teaser-project__title h5\">\n        <a href=\"https:\/\/www.drfz.de\/en\/forschungsprojekte\/3tr-taxonomy-treatment-targets-and-remission-taxonomie-behandlung-targets-und-remission\/\" aria-describedby=\"post-4515\"\n          title=\"Gehe zum Beitrag\" rel=\"bookmark\">\n          3TR &#8211; Taxonomy, Treatment, Targets and Remission (Taxonomie, Behandlung, Targets und Remission)        <\/a>\n      <\/div>\n    <\/div>\n  <\/div>\n<\/article>              <\/div>\n            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