{"id":3529,"date":"2024-12-04T10:44:48","date_gmt":"2024-12-04T10:44:48","guid":{"rendered":"https:\/\/www.drfz.de\/?post_type=working-group&#038;p=3529"},"modified":"2025-07-31T07:53:54","modified_gmt":"2025-07-31T07:53:54","slug":"angeborene-immunitat","status":"publish","type":"working-group","link":"https:\/\/www.drfz.de\/en\/arbeitsgruppen\/angeborene-immunitat\/","title":{"rendered":"Innate Immunity"},"content":{"rendered":"\n  <section id=\"about-us\"\n           class=\"section accordion  alignwide  toc-item\"\n           data-open=\"multiple\">\n    <div class=\"container container--center container--medium\">\n              <h2 class=\"h3 section__heading launimation slideBottom\">About us<\/h2>\n      \n      \n      \n              <div id=\"panel-\"\n             class=\"accordion__category active\" role=\"tabpanel\"\n             aria-labelledby=\"tab-\">\n                    <script type=\"application\/ld+json\">\n            {\n              \"@context\": \"https:\/\/schema.org\",\n              \"@type\": \"FAQPage\",\n              \"mainEntity\": [{\"@type\": \"Question\",\"name\": \"Imprinting of effector programs in ILCs\",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"The signals and innate receptors instructing the different effector programs and their execution in ILCs remain largely unknown. Such innate sensors could also enhance effector functions in T cells, thus promoting inflammation in a TCR-independent fashion. Therefore, our main research focus is devoted to study the innate modules and triggers employed by ILCs and T cells to initiate and maintain inflammation in a TCR-independent fashion and to understand whether distinct inflammatory programs can be imprinted in ILCs to promote rheumatic diseases.\"}},{\"@type\": \"Question\",\"name\": \"Innate activating receptors\",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"Recently, we have described a specific recognition strategy by Natural Killer (NK) cells which, in the absence of rearranged receptors, can detect mutated peptides derived from virus and host. Specific peptide recognition drives activation and expansion of a specialized subset of adaptive NK cells and contributes to determine their imprinting of pro-inflammatory cytokines. This data have important implications for our understanding of non-self and self-recognition by lymphocytes and how its dysregulation can lead to loss of tolerance and autoimmunity. Our data also indicate that innate activating receptors, such as NKG2D, also regulate Th1\/Th17 cell-mediated responses in arthritis, thereby identifying innate activating receptors as potential check points and therapeutic targets for inflammatory diseases.\nAltogether, the identification of the innate triggers and the specific signals driving the acquisition and the stable imprinting of distinct inflammatory programs in ILCs and T cells will be important to develop potentially new targets for the amelioration of chronic inflammation in rheumatic diseases.\"}},{\"@type\": \"Question\",\"name\": \"Inflammatory Memory and Innate Clonality\",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"Rapid response to pathogens involves a pool of innate immune effector cells which respond promptly to infection. However, innate cells can differentiate after pathogen encounters and remember past experiences, acquiring memory-like features. We have found that human memory-like natural killer (NK) cells undergo global epigenetic remodelling and expand clonally in response to cytomegalovirus infection.\nWe seek to identify the mechanisms driving the acquisition, selection and maintenance of public and private clonal memory in human NK cells. Our working hypothesis is that NK cell clonal expansions might increase NK cell fitness and effector potential but also enhance the risk of oncogenic mutations and of inflammatory disorders.\"}}]\n            }\n          <\/script>\n\n          <div class=\"accordion__content\">\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69dc4cb49f8e2_0\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">Imprinting of effector programs in ILCs<\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69dc4cb49f8e2_0\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p>The signals and innate receptors instructing the different effector programs and their execution in ILCs remain largely unknown. Such innate sensors could also enhance effector functions in T cells, thus promoting inflammation in a TCR-independent fashion. Therefore, our main research focus is devoted to study the innate modules and triggers employed by ILCs and T cells to initiate and maintain inflammation in a TCR-independent fashion and to understand whether distinct inflammatory programs can be imprinted in ILCs to promote rheumatic diseases.<\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69dc4cb49f8e2_1\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">Innate activating receptors<\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69dc4cb49f8e2_1\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p>Recently, we have described a specific recognition strategy by Natural Killer (NK) cells which, in the absence of rearranged receptors, can detect mutated peptides derived from virus and host. Specific peptide recognition drives activation and expansion of a specialized subset of adaptive NK cells and contributes to determine their imprinting of pro-inflammatory cytokines. This data have important implications for our understanding of non-self and self-recognition by lymphocytes and how its dysregulation can lead to loss of tolerance and autoimmunity. Our data also indicate that innate activating receptors, such as NKG2D, also regulate Th1\/Th17 cell-mediated responses in arthritis, thereby identifying innate activating receptors as potential check points and therapeutic targets for inflammatory diseases.<\/p>\n<p>Altogether, the identification of the innate triggers and the specific signals driving the acquisition and the stable imprinting of distinct inflammatory programs in ILCs and T cells will be important to develop potentially new targets for the amelioration of chronic inflammation in rheumatic diseases.<\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69dc4cb49f8e2_2\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">Inflammatory Memory and Innate Clonality<\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69dc4cb49f8e2_2\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p>Rapid response to pathogens involves a pool of innate immune effector cells which respond promptly to infection. However, innate cells can differentiate after pathogen encounters and remember past experiences, acquiring memory-like features. We have found that human memory-like natural killer (NK) cells undergo global epigenetic remodelling and expand clonally in response to cytomegalovirus infection.<\/p>\n<p>We seek to identify the mechanisms driving the acquisition, selection and maintenance of public and private clonal memory in human NK cells. Our working hypothesis is that NK cell clonal expansions might increase NK cell fitness and effector potential but also enhance the risk of oncogenic mutations and of inflammatory disorders.<\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                      <\/div>\n        <\/div>\n          <\/div>\n  <\/section>\n\n\n\n\n  <section id=\"team\"\n           class=\"section accordion  alignwide  toc-item\"\n           data-open=\"multiple\">\n    <div class=\"container container--center container--medium\">\n              <h2 class=\"h3 section__heading launimation slideBottom\">Team<\/h2>\n      \n      \n      \n              <div id=\"panel-\"\n             class=\"accordion__category active\" role=\"tabpanel\"\n             aria-labelledby=\"tab-\">\n                    <script type=\"application\/ld+json\">\n            {\n              \"@context\": \"https:\/\/schema.org\",\n              \"@type\": \"FAQPage\",\n              \"mainEntity\": [{\"@type\": \"Question\",\"name\": \"Members\",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"Group leader\nProf. Chiara Romagnani, MD, Phd\nScientists\nDr. Christina Stehle\nDr. Timo R\u00fcckert\nPh.D. students\nNils M\u00fcller\nChristoforos Dimitropoulos\nOliver Knight\nAlexandra Forrai\nKlara Penkert\nRamon Ranka\nMaximilian Mandry (MD\/PHD Student)\nMaximilian Riedel\nAsta Perl\nMelissa Quadflieg\nTechnician\nMarion Klemm\nLaura Puccio\nCoordination\nDr. Svenja R\u00fchland\"}}]\n            }\n          <\/script>\n\n          <div class=\"accordion__content\">\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69dc4cb4a05cb_0\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">Members<\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69dc4cb4a05cb_0\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p><strong>Group leader<br \/>\n<\/strong>Prof. Chiara Romagnani, MD, Phd<\/p>\n<p><strong>Scientists<br \/>\n<\/strong>Dr. Christina Stehle<br \/>\nDr. Timo R\u00fcckert<\/p>\n<p><strong>Ph.D. students<br \/>\n<\/strong>Nils M\u00fcller<br \/>\nChristoforos Dimitropoulos<br \/>\nOliver Knight<br \/>\nAlexandra Forrai<br \/>\nKlara Penkert<br \/>\nRamon Ranka<br \/>\nMaximilian Mandry (MD\/PHD Student)<br \/>\nMaximilian Riedel<br \/>\nAsta Perl<br \/>\nMelissa Quadflieg<\/p>\n<p><strong>Technician<br \/>\n<\/strong>Marion Klemm<br \/>\nLaura Puccio<\/p>\n<p><strong>Coordination<\/strong><br \/>\nDr. Svenja R\u00fchland<\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                      <\/div>\n        <\/div>\n          <\/div>\n  <\/section>\n\n\n\n\n  <section id=\"main-cooperation-partners\"\n           class=\"section accordion  alignwide  toc-item\"\n           data-open=\"multiple\">\n    <div class=\"container container--center container--medium\">\n              <h2 class=\"h3 section__heading launimation slideBottom\">Main cooperation partners<\/h2>\n      \n      \n      \n              <div id=\"panel-\"\n             class=\"accordion__category active\" role=\"tabpanel\"\n             aria-labelledby=\"tab-\">\n                    <script type=\"application\/ld+json\">\n            {\n              \"@context\": \"https:\/\/schema.org\",\n              \"@type\": \"FAQPage\",\n              \"mainEntity\": [{\"@type\": \"Question\",\"name\": \"Within DRFZ\/Charit\u00e9\",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"Andreas Diefenbach, Christoph Klose, Leif Ludwig, Tillmann Kallinich, Anja Hauser, Mir-Farzin Mashreghi, Hyun-Dong Chang, Ahmed Hegazy, Britta Siegmund\"}},{\"@type\": \"Question\",\"name\": \"National academia\",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"Thomas H\u00f6fer (DKFZ), Veit Buchholz (TUM), Thomas Sch\u00fcler (Univ Magdeburg), Georg Gasteiger (Univ W\u00fcrzburg)\"}},{\"@type\": \"Question\",\"name\": \"National industry\",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"Mario Assenmacher, Miltenyi Biotech\"}},{\"@type\": \"Question\",\"name\": \"International academia\",\"acceptedAnswer\": {\"@type\": \"Answer\",\"text\": \"Eric Vivier, (Centre d\u2019Immunologie de Marseille-Luminy,\u00a0 Marseille), Joseph Sun (MSKCC, NY), Michael Birnbaum (MIT Boston), Caleb Lareau (MSKCC, NY), Domenico Mavilio (Humanitas, Milano)\"}}]\n            }\n          <\/script>\n\n          <div class=\"accordion__content\">\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69dc4cb4a14e4_0\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">Within DRFZ\/Charit\u00e9<\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69dc4cb4a14e4_0\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p>Andreas Diefenbach, Christoph Klose, Leif Ludwig, Tillmann Kallinich, Anja Hauser, Mir-Farzin Mashreghi, Hyun-Dong Chang, Ahmed Hegazy, Britta Siegmund<\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69dc4cb4a14e4_1\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">National academia<\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69dc4cb4a14e4_1\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p>Thomas H\u00f6fer (DKFZ), Veit Buchholz (TUM), Thomas Sch\u00fcler (Univ Magdeburg), Georg Gasteiger (Univ W\u00fcrzburg)<\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69dc4cb4a14e4_2\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">National industry<\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69dc4cb4a14e4_2\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p>Mario Assenmacher, Miltenyi Biotech<\/p>\n\n                                          <\/div>\n                  <\/div>\n                <\/div>\n              <\/div>\n                          <div class=\"accordion-item  box box--accordion over launimation slideBottom\">\n                <button class=\"accordion-item__title\"\n                        aria-expanded=\"false\"\n                        aria-controls=\"accordion_69dc4cb4a14e4_3\"\n                        aria-label=\"Zeige den Inhalt an\">\n                    <span class=\"accordion-item__title-wrapper\">\n                      <span class=\"accordion-item__title-main h5\">International academia<\/span>\n                                          <\/span>\n                  <span class=\"icon-wrapper\"><\/span>\n                <\/button>\n\n                <div class=\"accordion-item__content-container\" id=\"accordion_69dc4cb4a14e4_3\">\n                  <div class=\"accordion-item__content\">\n                    \n                    <div class=\"accordion-item__content-text wysiwyg\">\n                      <p>Eric Vivier, (Centre d\u2019Immunologie de Marseille-Luminy,\u00a0 Marseille), Joseph Sun (MSKCC, NY), Michael Birnbaum (MIT Boston), Caleb Lareau (MSKCC, NY), Domenico Mavilio (Humanitas, Milano)<\/p>\n\n                                          <\/div>\n                  <\/div>\n                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role=\"none\">\n      <span class=\"tag-pill\">\n        <span class=\"visually-hidden\">Kategorie: <\/span>\n        For patients      <\/span>\n    <\/li>\n  <\/ul>    <\/div>\n\n    <div class=\"teaser-post__body\">\n      <time class=\"date\" datetime=\"2025-05-22 15:56:22\">22.05.2025<\/time>\n      <div class=\"teaser-post__title h5\">\n        <a href=\"https:\/\/www.drfz.de\/en\/neuigkeiten\/early-recognition-targeted-intervention-staying-healthy-immunoprecept-unites-top-berlin-research\/\" aria-describedby=\"post-17475\"\n          title=\"Gehe zum Beitrag\" rel=\"bookmark\">\n          Early recognition, targeted intervention, staying healthy: ImmunoPreCept unites top Berlin research        <\/a>\n      <\/div>\n\n              <div class=\"teaser-post__excerpt ellipsis\">\n          The DRFZ is part of the new Cluster of Excellence The German Rheumatology Research Center, a Leibniz Institute, is partner in the new Berlin Cluster\u2026        <\/div>\n          <\/div>\n  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href=\"https:\/\/www.drfz.de\/en\/neuigkeiten\/chiara-romagnani-is-a-new-member-of-the-leopoldina\/\" aria-describedby=\"post-9607\"\n          title=\"Gehe zum Beitrag\" rel=\"bookmark\">\n          Chiara Romagnani is a new member of the Leopoldina        <\/a>\n      <\/div>\n\n              <div class=\"teaser-post__excerpt ellipsis\">\n          Prof. Dr. Chiara Romagnani, Liaison Group Leader at the DRFZ and Director of the Institute of Medical Immunology at Charit\u00e9 &#8211; Universit\u00e4tsmedizin Berlin is a\u2026        <\/div>\n          <\/div>\n  <\/div>\n<\/article>              <\/div>\n                          <div class=\"swiper-slide\">\n                \n<article\n  id=\"post-8290\" class=\"teaser-post box box--min-height launimation slideBottom graded-box post-8290 post type-post status-publish format-standard has-post-thumbnail hentry category-news-en tag-innate-immunity tag-program-area-1 programme-area-tax-programme-area-1 working-group-tax-innate-immunity\">\n  <div class=\"teaser-post__wrap\">\n    <div class=\"teaser-post__cats\">\n      \n<ul class=\"tag-pills tag-pills--small\" role=\"none\">\n      <li role=\"none\">\n      <span class=\"tag-pill\">\n        <span class=\"visually-hidden\">Kategorie: <\/span>\n        News      <\/span>\n    <\/li>\n  <\/ul>    <\/div>\n\n    <div class=\"teaser-post__body\">\n      <time class=\"date\" datetime=\"2024-12-20 09:23:00\">20.12.2024<\/time>\n      <div class=\"teaser-post__title h5\">\n        <a href=\"https:\/\/www.drfz.de\/en\/neuigkeiten\/pettenkofer-preis-fuer-timo-rueckert\/\" aria-describedby=\"post-8290\"\n          title=\"Gehe zum Beitrag\" rel=\"bookmark\">\n          Pettenkofer Prize for Timo R\u00fcckert        <\/a>\n      <\/div>\n\n              <div class=\"teaser-post__excerpt ellipsis\">\n          Dr. Timo R\u00fcckert, postdoc in Chiara Romagnani\u2019s liaison research group at DRFZ and the Institute of Medical Immunology at Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, has been\u2026        <\/div>\n          <\/div>\n  <\/div>\n<\/article>              <\/div>\n            \n          <\/div><!-- swiper-wrapper -->\n\n                      <div class=\"slider__pagination slider__pagination--contained\">\n              <button class=\"slider__button-prev\"><\/button>\n              <button class=\"slider__button-next\"><\/button>\n            <\/div>\n          \n                      <div class=\"slider__skip-links-container\">\n              <a id=\"after-slider-block_714bd69d7bd6b644f160bc0ac5820941\"\n                 href=\"#before-slider-block_714bd69d7bd6b644f160bc0ac5820941\"\n                 class=\"skip-link\">Go to beginning of slider<\/a>\n            <\/div>\n                  <\/div>\n\n                          <div class=\"related-news__load-more text-center\">\n            \n<div class=\"load-more\">\n  <script type=\"application\/json\">\n      {\"customButtonText\":\"Show 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