AG Kallinich

Understanding chronic inflammation in the developing children

Einleitung
Mitarbeiter
Kooperationspartner
Ausgewählte Publikationen

Chronic inflammation in childhood

Juvenile idiopathic arthritis (JIA) is the most frequent chronic inflammatory disease in childhood with a prevalence of approximately 1 : 1000. Since the clinical presentation, the prevalence of co-morbidities, and the prognosis of children with JIA differ significantly from adults with different rheumatic diseases, knowledge about the pathogenesis obtained in adults cannot simply be transferred to children. JIA-specific markers for classifying disease subtypes, defining endotypes and predicting therapeutic response are missing.

In cooperation with the research group of Mir-Farzin Mashreghi, we aim to define molecular immune cell signatures in the inflamed synovia and in the peripheral blood of children suffering from different forms of JIA. With these results we will define markers specific for the different forms of JIA which can be traced in peripheral blood. Using data from newly established cohorts, we aim to analyze the suitability of these tools to classify the disease, monitor the disease activity and finally to predict the response to different therapeutic regimens. This translational approach will help to establish JIA-specific endotypes, which are fundamental for the development of personalised treatment strategies.

Monogenic alterations causing systemic inflammatory diseases usually manifest in early childhood. They are characterized by excessive production of pro-inflammatory cytokines and are referred to as autoinflammatory diseases (AID). In the last decade, analysis of these underlying molecular genetic alterations has uncovered new immunological pathomechanisms, e.g. the dysregulation of the inflammasome reaction. Analyzing our cohort of patients with defined, (e.g. interferonopathies, inflammasomopathies) as well as unassigned AID, we aim to comprehensively immunophenotype different immune cell populations in order to develop diagnostic markers and unravel the pathological processes leading to excessive cytokine production.

Gruppenleiter
    PD Dr. med. Tilmann Kallinich

PD Dr. med. Tilmann Kallinich

Klinik für Pädiatrie m.S. Pneumologie und Immunologie mit Intensivmedizin
Charité – Universitätsmedizin Berlin
Augustenburger Platz 1
13353 Berlin
tilmann.kallinich@charite.de

Leiter der Sektion Rheumatologie / Oberarzt / Zusatzbezeichnung Kinderrheumatologie

BIH Clinical Fellow, gefördert durch die Stiftung Charité

Keywords
Juvenile idiopathic arthritis
Autoinflammation
Monogenic diseases
Immunophenotyping

Weiter zu Mitarbeiter

Group leader
PD Dr. Tilmann Kallinich

Clinical Scientist
Dr. Carl Christoph Goetzke

Clinicians
Dr. Sae-Lim von Stuckrad
Dr. Banu Orak

Gruppenleiter
    PD Dr. med. Tilmann Kallinich

PD Dr. med. Tilmann Kallinich

Klinik für Pädiatrie m.S. Pneumologie und Immunologie mit Intensivmedizin
Charité – Universitätsmedizin Berlin
Augustenburger Platz 1
13353 Berlin
tilmann.kallinich@charite.de

Leiter der Sektion Rheumatologie / Oberarzt / Zusatzbezeichnung Kinderrheumatologie

BIH Clinical Fellow, gefördert durch die Stiftung Charité

Keywords
Juvenile idiopathic arthritis
Autoinflammation
Monogenic diseases
Immunophenotyping

Weiter zu Kooperationspartner
  • Dr. Dirk Föll, Universität Münster, Klinik für Pädiatrische Rheumatologie und Immunologie, Münster, Germany
  • Dr. Raphaela Goldbach-Mansky, National Institut of Health, Translational Autoinflammatory Disease Studies Section, Bethesda, USA
  • Dr. Elke Krüger, Universitätsmedizin Greifswald, Institut für Medizinische Biochemie und Molekularbiologie, Greifswald, Germany
  • Dr. Klaus Tenbrock, Klinik für Kinder- und Jugendmedizin, Aachen, Germany
Gruppenleiter
    PD Dr. med. Tilmann Kallinich

PD Dr. med. Tilmann Kallinich

Klinik für Pädiatrie m.S. Pneumologie und Immunologie mit Intensivmedizin
Charité – Universitätsmedizin Berlin
Augustenburger Platz 1
13353 Berlin
tilmann.kallinich@charite.de

Leiter der Sektion Rheumatologie / Oberarzt / Zusatzbezeichnung Kinderrheumatologie

BIH Clinical Fellow, gefördert durch die Stiftung Charité

Keywords
Juvenile idiopathic arthritis
Autoinflammation
Monogenic diseases
Immunophenotyping

Weiter zu Ausgewählte Publikationen

[Evidence-based treatment recommendations for familial Mediterranean fever : A joint statement by the Society for Pediatric and Adolescent Rheumatology and the German Society for Rheumatology].
Kallinich T, Blank N, Braun T, Feist E, Kiltz U, Neudorf U, Oommen PT, Weseloh C, Wittkowski H, Braun J.
Z Rheumatol. 2019 Feb;78(1):91-101

Classification criteria for autoinflammatory recurrent fevers.
Gattorno M, Hofer M, Federici S, Vanoni F, Bovis F, Aksentijevich I, Anton J, Arostegui JI, Barron K, Ben-Cherit E, Brogan PA, Cantarini L, Ceccherini I, De Benedetti F, Dedeoglu F, Demirkaya E, Frenkel J, Goldbach-Mansky R, Gul A, Hentgen V, Hoffman H, Kallinich T, Kone-Paut I, Kuemmerle-Deschner J, Lachmann HJ, Laxer RM, Livneh A, Obici L, Ozen S, Rowczenio D, Russo R, Shinar Y, Simon A, Toplak N, Touitou I, Uziel Y, van Gijn M, Foell D, Garassino C, Kastner D, Martini A, Sormani MP, Ruperto N; Eurofever Registry and the Paediatric Rheumatology International Trials Organisation (PRINTO).
Ann Rheum Dis. 2019 Apr 24. pii: annrheumdis-2019-215048. doi: 10.1136/annrheumdis-2019-215048. [Epub ahead of print]

Familial Mediterranean fever in children and adolescents: factors for colchicine dosage and predicting parameters for dose increase.
Knieper AM, Klotsche J, Lainka E, Berger T, Dressler F, Jansson AF, Rietschel C, Oommen PT, Berendes R, Niehues T, Neudorf U, Foell D, Wittkowski H, Kallinich T.
Rheumatology (Oxford). 2017 Sep 1;56(9):1597-1606. doi: 10.1093/rheumatology/kex222.

Musculoskeletal Disease in MDA5-Related Type I Interferonopathy: A Mendelian Mimic of Jaccoud’s Arthropathy.
de Carvalho LM, Ngoumou G, Park JW, Ehmke N, Deigendesch N, Kitabayashi N, Melki I, Souza FFL, Tzschach A, Nogueira-Barbosa MH, Ferriani V, Louzada-Junior P, Marques W Jr, Lourenço CM, Horn D, Kallinich T, Stenzel W, Hur S, Rice GI, Crow YJ.
Arthritis Rheumatol. 2017 Oct;69(10):2081-2091. doi: 10.1002/art.40179. Epub 2017 Aug 22.

Juvenile arthritis caused by a novel FAMIN (LACC1) mutation in two children with systemic and extended oligoarticular course.
Kallinich T, Thorwarth A, von Stuckrad SL, Rösen-Wolff A, Luksch H, Hundsdoerfer P, Minden K, Krawitz P.
Pediatr Rheumatol Online J. 2016 Nov 24;14(1):63.

Gruppenleiter
    PD Dr. med. Tilmann Kallinich

PD Dr. med. Tilmann Kallinich

Klinik für Pädiatrie m.S. Pneumologie und Immunologie mit Intensivmedizin
Charité – Universitätsmedizin Berlin
Augustenburger Platz 1
13353 Berlin
tilmann.kallinich@charite.de

Leiter der Sektion Rheumatologie / Oberarzt / Zusatzbezeichnung Kinderrheumatologie

BIH Clinical Fellow, gefördert durch die Stiftung Charité

Keywords
Juvenile idiopathic arthritis
Autoinflammation
Monogenic diseases
Immunophenotyping

Weiter zu Einleitung