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Schwiete-Labor für Mikrobiota und Entzündungen
Prof. Dr. Hyun-Dong Chang
 

Schwiete-Labor für Mikrobiota und Entzündungen

Prof. Dr. Hyun-Dong Chang

Deutsches Rheuma-Forschungszentrum Berlin
Charitéplatz 1
10117 Berlin
und
Fachgebiet Zytometrie
Institut für Biotechnologie
Fakultät III – Prozesswisschenschaften
Technische Universität Berlin
Tel: +49 (0)30 28460-761 Fax: +49 (0)30 28460-603 chang@drfz.de

CV - Akademischer Werdegang und Schlüsselpublikationen (nur auf Englisch verfügbar)

Scientific Career
  • December 2020 joint appointment as Professor for Cytometry by the Technische Universität Berlin and the DRFZ
  • since 2017 Group leader “Schwiete Laboratory for Microbiota and Inflammation”
  • since 2012 Scientific leader of the Flow Cytometry and Cell Sorting Core Facility (FCCF) of the DRFZ Berlin
  • since 2011 Tenure scientist at the DRFZ Berlin
  • 2007 – 2011 Postdoctoral fellow at the Deutsches Rheuma-Forschungszentrum Berlin
  • 2005 – 2007 Postdoctoral fellow of the Graduiertenkolleg 1121 „Genetic and immunological determinants of pathogen-host-interaction“ funded by the German Research Council (DFG)
Education
  • 2018 Habilitation at the Humboldt University Berlin
  • 1999 – 2005 Doctoral thesis („summa cum laude“) with Prof. Dr. Andreas Radbruch
  • 1998 – 1999 Diploma thesis with Prof. Dr. Maurizio Zanetti, Cancer Center, University of California San Diego (UCSD)
  • 1999 Diploma in Biology at the Free University Berlin (final grade: “sehr gut”)
Boards and Memberships

Boards

  • 2014 – 2016 President of the German Society for Cytometry (DGfZ)
  • since 2016 Organisation Committee of the Spring School of Immunology of the German Society for Immunology

Memberships

  • German Society for Immunology (DGfI)
  • German Society for Cytometry (DGfZ)
Third Party Funding
  • 2019 – 2026 EU H2020 IMI2 3TR
  • 2018 – 2022 DFG SFB TRR241 “Immune-Epithelial Communication in Inflammatory Bowel Diseases”
  • 2017 – 2022 Schwiete-Foundation “Microbiota, Chronic Inflammation and Cancer”
  • 2017 – 2022 EU H2020 IMI2 RTCure
  • 2017 – 2021 DFG SFB TRR130 „B cells: Immunity and Autoimmunity”
  • 2015 – 2019 BMBF Forschungsverbund „Neuroimmunology and Pain (NeuroImpa)“
Key Publications
  1. Beller A, Kruglov A, Durek P, von Goetze V, Werner K, Heinz GA, Ninnemann J, Lehmann K, Maier R, Hoffmann U, Riedel R, Heiking K, Zimmermann J, Siegmund B, Mashreghi MF, Radbruch A, Chang HD. Specific microbiota enhances intestinal IgA levels by inducing TGF-β in T follicular helper cells of Peyer’s patches in mice. Eur J Immunol. 2020 Jun;50(6):783-794. doi: 10.1002/eji.201948474. Epub 2020 Feb 27. PMID: 32065660.

 

  1. Müller S, Chang HD. Microorganisms and Their Activities Within Microbial Communities. Cytometry A. 2020 Jul;97(7):681-682. doi: 10.1002/cyto.a.24175. Epub 2020 Jul 10. PMID: 32583569.
  2. Chang HD, Tokoyoda K, Hoyer B, Alexander T, Khodadadi L, Mei H, Dörner T, Hiepe F, Burmester GR, Radbruch A. Pathogenic memory plasma cells in autoimmunity. Curr Opin Immunol. 2019 Oct 29;61:86-91. doi:10.1016/j.coi.2019.09.005
  3. Cossarizza A, Chang HD, Radbruch A et al Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition). Eur J Immunol. 2019 Oct;49(10):1457-1973. doi: 10.1002/eji.201970107.
  4. Hradilkova K, Maschmeyer P, Westendorf K, Schliemann H, Husak O, von Stuckrad ASL, Kallinich T, Minden K, Durek P, Grün JR, Chang HD*, Radbruch A*. Regulation of Fatty Acid Oxidation by Twist 1 in the Metabolic Adaptation of T Helper Lymphocytes to Chronic Inflammation. Arthritis Rheumatol. 2019 Oct;71(10):1756-1765. doi: 10.1002/art.40939.
  5. Neumann C, Blume J, Roy U, Teh PP, Vasanthakumar A, Beller A, Liao Y, Heinrich F, Arenzana TL, Hackney JA, Eidenschenk C, Gálvez EJC, Stehle C, Heinz GA, Maschmeyer P, Sidwell T, Hu Y, Amsen D, Romagnani C, Chang HD, Kruglov A, Mashreghi MF, Shi W, Strowig T, Rutz S, Kallies A, Scheffold A. c-Maf-dependent T(reg) cell control of intestinal T(H)17 cells and IgA establishes host-microbiota homeostasis. Nat Immunol. 2019 Apr;20(4):471-481. doi:10.1038/s41590-019-0316-2.
  6. Zimmermann J, Durek P, Kühl AA, Schattenberg F, Maschmeyer P, Siracusa F, Lehmann K, Westendorf K, Weber M, Riedel R, Müller S, Radbruch A, Chang HD. The intestinal microbiota determines the colitis-inducing potential of T-bet-deficient Th cells in mice. Eur J Immunol. 2017 Sep 6. doi: 10.1002/eji.201747100.
  7. Zimmermann J, Hübschmann T, Schattenberg F, Schumann J, Durek P, Riedel R, Friedrich M, Glauben R, Siegmund B, Radbruch A, Müller S, Chang HD. High-resolution microbiota flow cytometry reveals dynamic colitis-associated changes in fecal bacterial composition. Eur J Immunol. 2016 May;46(5):1300-3. doi: 10.1002/eji.201646297.
  8. Zimmermann J, Kühl AA, Weber M, Grün JR, Löffler J, Haftmann C, Riedel R, Maschmeyer P, Lehmann K, Westendorf K, Mashreghi MF, Löhning M, Mack M, Radbruch A, Chang HD. T-bet expression by Th cells promotes type 1 inflammation but is dispensable for colitis. Mucosal Immunol. 2016 Nov;9(6):1487-1499. doi: 10.1038/mi.2016.5.
  9. Köck J, Kreher S, Lehmann K, Riedel R, Bardua M, Lischke T, Jargosch M, Haftmann C, Bendfeldt H, Hatam F, Mashreghi MF, Baumgrass R, Radbruch A, Chang HD. Nuclear factor of activated T cells regulates the expression of interleukin-4 in Th2 cells in an all-or-none fashion. J Biol Chem. 2014 Sep 26;289(39):26752-61. doi: 10.1074/jbc.M114.587865.
  10. Lexberg MH, Taubner A, Förster A, Albrecht I, Richter A, Kamradt T, Radbruch A, Chang HD. Th memory for interleukin-17 expression is stable in vivo. Eur J Immunol. 2008 Oct;38(10):2654-64. doi: 10.1002/eji.200838541.
  11. Niesner U, Albrecht I, Janke M, Doebis C, Loddenkemper C, Lexberg MH, Eulenburg K, Kreher S, Koeck J, Baumgrass R, Bonhagen K, Kamradt T, Enghard P, Humrich JY, Rutz S, Schulze-Topphoff U, Aktas O, Bartfeld S, Radbruch H, Hegazy AN, Löhning M, Baumgart DC, Duchmann R, Rudwaleit M, Häupl T, Gitelman I, Krenn V, Gruen J, Sieper J, Zeitz M, Wiedenmann B, Zipp F, Hamann A, Janitz M, Scheffold A, Burmester GR, Chang HD, Radbruch A. Autoregulation of Th1-mediated inflammation by twist1. J Exp Med. 2008 Aug 4;205(8):1889-901. doi: 10.1084/jem.20072468.
AG Chang
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