Startseite Über uns Köpfe Dr. rer. nat. Karl Skriner
TheRAdiagnostics
Dr. rer. nat. Karl Skriner
 

TheRAdiagnostics

Dr. rer. nat. Karl Skriner

Medizinische Klinik mit Schwerpunkt Rheumatologie und klinische Immunologie CCM
Gebäude: Virchowweg 11
(5. Ebene - Raum 011)
Charitéplatz 1
10117 Berlin
Tel: +49(0) 30 450 513 229 karl.skriner@charite.de

CV - Akademischer Werdegang und Schlüsselpublikationen (nur auf Englisch verfügbar)

Scientific Career

Since 2021 Liaison Group Leader TheRAdiagnostics, DRFZ Berlin

Since 2001 Charité – Universitätsmedizin Berlin, Institute for Rheumatology and Clinical Immunolology: Research Group Leader “Immunomics”

2012 – 2015 Drug Response Dx GmbH, Hennigsdorf, Germany, CSO and founder of a spin-off of the Max Planck Society

1996 – 2001 Research Assistant, University of Vienna, Institute for Rheumatology AKH Vienna

Education

1996 PhD in Genetics, University of Vienna, Austria

1992 Master’s Degree in Biology, Major in Genetics, University of Vienna, Austria

2012 Master of Business Administration (MBA), University of Potsdam, Germany

1996 Final Examen, BG BRG Grammar School Völkermarkt

Boards and Memberships

2018 Associate Member of the Medical Department, Karolinska, Sweden

Member: German Society of Immunology (DGfI),

Member: Society for the Promotion of Immunodiagnostics e.V. (GFID)

Awards

2018 Researcher Award at the 38th European Workshop Rheumatology

2006 Investigator Award at the 26th European Workshop Rheumatology

2005 EULAR: Basic science abstract award Vienna

2002 Professor at the Central University of Venezuela Caracas, USA.

1998 Junior Researcher Award at the 18th European Workshop for Rheumatology

1997 State Prize for Rheumatism Research 1997 for basic scientific research in the areas of Rheumatology by Science Minister Austria.

1996 Dissertation Award of the Austrian Society for Allergology and Allergology

Third Party Funding (Selection)

RA-Prädikt: Entwicklung eines Verfahrens zur prädiktiven Bewertung des Therapieansprechens bei Patienten mit Rheumatoider Arthritis auf der Basis der Massenspektrometrie. BMBF AIF.1.3.2021-31.7.2023, 220.000 € )

KMU-Innovativ-Verbundprojekt: Therapiebegleitende in vitro-diagnostische Assays in der rheumatoiden Arthritis (tIVDiRA) – Teilvorhaben: Immunologische Analyse und Charakterisierung der Biomarker: BMBF: 01.05.2017 – 30.06.2020 (386.000 €)

Verbundvorhaben: ArthroMark – Biomarker und Bildgebung zur Diagnose und Stratifizierung der Rheumatoiden Arthritis und Spondyloarthritis. Evaluation of diagnostic biomarkers for prediction of therapy response Förderkennzeichen: 01EC1401 Förderzeitraum: BMBF:  01.02.2015 bis 31.10.2019 (348.0000€)

Key Publications

1: Marklein B, Jenning M, Konthur Z, Häupl T, Welzel F, Nonhoff U, Krobitsch S, Mulder DM, Koenders MI, Joshua V, Cope AP, Shlomchik MJ, Anders HJ, Burmester GR, Hensvold A, Catrina AI, Rönnelid J, Steiner G, Skriner K.
The citrullinated/native index of autoantibodies against hnRNP-DL predicts an individual “window of treatment success” in RA patients.
Arthritis Res Ther. 2021 Sep 14;23(1):239. doi: 10.1186/s13075-021-02603-x. PMID: 34521462; PMCID: PMC8439038.

2: Kreye J, Reincke SM, Kornau HC, Sanchez-Sendin E, Corman VM, Liu H, Yuan M,Wu NC, Zhu X, Lee CD, Trimpert J, Hoeltje M, Dietert K, Stoeffler L, von Wardenburg N, van Hoof S, Homeyer MA, Hoffmann J, Abdelgawad A, Gruber AD, Bertzbach LD, Vladimirova D, Li LY, Barthel PC, Skriner K, Hocke AC, Hippenstiel S, Witzenrath M, Suttorp N, Kurth F, Franke C, Endres M, Schmitz D, Jeworowski LM, Richter A, Schmidt ML, Schwarz T, Mueller MA, Drosten C, Wendisch D, Sander LE, Osterrieder N, Wilson IA, Pruess H.
A SARS-CoV-2 neutralizing antibody protects from lung pathology in a COVID-19 hamster model.
Cell.2020 Nov 12;183(4):1058-1069.e19. doi: 10.1016/j.cell.2020.09.049. Epub 2020 Sep 23.

3: Jenning M, Marklein B, Ytterberg J, Zubarev RA, Joshua V, van Schaardenburg D, van de Stadt L, Catrina AI, Nonhoff U, Häupl T, Konthur Z, Burmester GR, Skriner K.
Bacterial citrullinated epitopes generated by Porphyromonas gingivalis infection-a missing link for ACPA production.
Ann Rheum Dis. 2020 Sep;79(9):1194-1202. doi: 10.1136/annrheumdis-2019-216919. Epub 2020 Jun 12. PMID: 32532752..

4: Robinson WH, DiGennaro C, Hueber W, Haab BB, Kamachi M, Dean EJ, Fournel S, Fong D, Genovese MC, de Vegvar HE, Skriner K, Hirschberg DL, Morris RI, Muller S, Pruijn GJ, van Venrooij WJ, Smolen JS, Brown PO, Steinman L, Utz PJ.
Autoantigen microarrays for multiplex characterization of autoantibody responses.
Nat Med. 2002; 8(3):295-301.

5: Steen J, Forsström B, Sahlström P, Odowd V, Israelsson L, Krishnamurthy A, Badreh S, Mathsson Alm L, Compson J, Ramsköld D, Ndlovu W, Rapecki S, Hansson M, Titcombe PJ, Bang H, Mueller DL, Catrina AI, Grönwall C, Skriner K, Nilsson P,Lightwood D, Klareskog L, Malmström V.
Human plasma cell derived monoclonal antibodies to post-translationally modified proteins recognize amino acid motifs rather than specific proteins.
Arthritis Rheumatol. 2018 Aug 27

6: Lloyd Katy A., Wigerblad Gustaf, Sahlström Peter, Garimella Manasa G., Chemin Karine, Steen Johanna, Titcombe Philip J., Marklein Bianka, Zhou Diana, Stålesen Ragnhild, Ossipova Elena, Lundqvist Christina, Ekwall Olov, Rönnelid Johan, Mueller Daniel L., Karlsson Mikael C. I., Kaplan Mariana J., Skriner Karl, Klareskog Lars, Wermeling Fredrik, Malmström Vivianne, Grönwall Caroline.
Differential ACPA Binding to Nuclear Antigens Reveals a PAD-Independent Pathway and a Distinct Subset of Acetylation Cross-Reactive Autoantibodies in Rheumatoid Arthritis.
Frontiers in Immunology,V9 ,2019 ,3033.

7: Sohrabian A, Mathsson-Alm L, Hansson M, Knight A, Lysholm J, Cornillet M, Skriner K, Serre G, Larsson A, Weitoft T, Rönnelid J.
Number of individual ACPA reactivities in synovial fluid immune complexes, but not serum anti-CCP2 levels, associate with inflammation and joint destruction in rheumatoid arthritis.
Ann Rheum Dis. 2018 Sep;77(9):1345-1353

8: Hoffmann MH, Skriner K, Herman S, Baumann C, Steiner CW, Ospelt C, Meyer B, Gleiss A, Pfatschbacher J, Niederreiter B, Tuncel J, Zanoni G, Steiner G.
Nucleic acid-stimulated antigen-presenting cells trigger T cells to induce disease in a rat transfer model of inflammatory arthritis.
J Autoimmun. 2011; 36:288-300.

9: Skriner K, Hueber W, Süleymanoglu E, Höfler E, Krenn V, Smolen J, Steiner G.
AUF1, the regulator of tumor necrosis factor alpha messenger RNA decay, istargeted by autoantibodies of patients with systemic rheumatic diseases.
Arthritis Rheum. 2008; 58(2):511-20.

10: Skriner K, Adolph K, Jungblut PR, Burmester GR.
Association of citrullinated proteins with synovial exosomes.
Arthritis Rheum. 2006; 54(12):3809-

Seite drucken
Seite teilen
DRFZ NewsFlash abonnieren