Startseite Über uns Köpfe Dr. Koji Tokoyoda
Osteoimmunologie
Dr. Koji Tokoyoda
 

Osteoimmunologie

Dr. Koji Tokoyoda

Deutsches Rheuma-Forschungszentrum Berlin
Osteoimmunologie
Charitéplatz 1
10117 Berlin, Germany
Tel: +49 (0)30 28460-782 Fax: +49 (0)30 28460-604 tokoyoda@drfz.de

CV - Akademischer Werdegang und Schlüsselpublikationen (nur auf Englisch verfügbar)

Scientific Career
  • March 2020 Following call for professorship at Tottori University in Yonago, Japan
  • Since 2012 Group leader, Deutsches Rheuma-Forschungszentrum Berlin (DRFZ), Germany
  • 2011 – 2012 Associate professor, Chiba University, Chiba, Japan
  • 2009 – 2011 Independent assistant professor, Chiba University, Chiba, Japan
  • 2005 – 2009 Guest scientist, Deutsches Rheuma-Forschungszentrum Berlin (DRFZ), Germany
  • 2003 – 2005 Assistant professor, Institute of Frontier Medical Sciences, Kyoto University, Kyoto, Japan
  • 2002 – 2003 Research associate, Institute of Frontier Medical Sciences, Kyoto University, Kyoto, Japan
Education
  • 1999 – 2002 Ph.D., Pharmacology, Osaka University, Osaka, Japan
  • 1997 – 1999 M.S., Biology, Tokyo University of Sciences, Chiba, Japan
  • 1993 – 1997 B.S., Biology, Tokyo University of Sciences, Chiba, Japan
Boards and Memberships

Boards

  • Since 2011 Councilor, Japanese Society for Immunolog

Memberships

  • Since 2013 Member, German Society for Immunology (DGfI)
  • Since 1997 Member, Japanese Society for Immunology
Awards and Stipends

Awards

  • 2015 Chiba University Excellent Invention Award
  • 2012 Chiba University Advanced Science Award
  • 2010 Robert-Koch Post-doctorate prizes for young scientists
  • 2010 Japanese Society for Immunology Young Investigator Award

Stipends

  • 2007 – 2008 The Alexander von Humboldt Foundation, Research fellowship for Postdoctoral Researcher
  • 2006 The Uehara Memorial Foundation, Research Fellowship
Third Party Funding

Selection (from 2011 – ongoing)

  • 2020 Deutsche Forschungsgemeinschaft (DFG), Project-specific Workshops, “The 5th International Immunological Memory and Vaccine Forum”, 24.400 €
  • 2017 – 2020 Deutsche Forschungsgemeinschaft (DFG), Research grant TO 944/3-1, “Identification of antigen-presenting cells for memory T helper cells in the recall response”, 246.000 €
  • 2016 – 2019 Deutsche Forschungsgemeinschaft (DFG), Research grant TO 944/2-1, “Molecular characterization of survival niches for memory T helper cells in bone marrow”, 242.000 €
  • 2015 Deutsche Forschungsgemeinschaft (DFG), Project-specific Workshops, “The 3rd International Immunological Memory and Vaccine Forum”, 18.000 €
  • 2012 – 2015 Leibniz Gemeinschaft, SAW Network Project, “ImmunoMemory”, 156.000 € (my part, 781.000 € as total)
  • 2011 – 2012 Takeda Science Foundation (Japan), “Roles of T helper cell memory in the body”, 39.000 €
  • 2010 – 2012 Ministry of Education, Culture, Sports, Science and Technology (Japan), Young Scientists Class A, “Roles of T helper cell memory in the body”, 390.000 €
  • 2010 – 2012 Ministry of Education, Culture, Sports, Science and Technology (Japan), Scientific Research on Priority Areas, “Immune memory system of auto-reactive T helper cells”, 130.000 €
  • 2010 – 2011 Astellas Foundation for Research on Metabolic Disorders (Japan), “Generation of T helper cell memory in the body”, 13.000 €
  • 2010 – 2011 Uehara Memorial Foundation (Japan), “Dynamics of T helper cell memory in the body”, 26.000 €
Key Publications
  1. Tokoyoda K, Takemoto Y, Nakayama T, Arai T, and Kubo M. (2000) Synergism between the calmodulin-binding and autoinhibitory domains on calcineurin is essential for the induction of their phosphatase activity. J. Biol. 275:11728-11734.
  2. Tokoyoda K, Tsujikawa K, Matsushita H, Ono Y, Hayashi T, Harada Y, Abe R, Kubo M, and Yamamoto H. (2004) Up-regulation of IL-4 production by the activated cAMP/cAMP-dependent protein kinase (protein kinase A) pathway in CD3/CD28-stimulated naive T cells. Int. Immunol. 16:643-653.
  3. Tokoyoda K, Egawa T, Sugiyama T, Choi BI, and Nagasawa T. (2004) Cellular niches controlling B lymphocyte behavior within bone marrow during development. Immunity 20:707-718.
  4. Tokoyoda K, Zehentmeier S, Hegazy AN, Albrecht I, Grün JR, Löhning M, and Radbruch A. (2009) Professional memory CD4+ T lymphocytes preferentially reside and rest in the bone marrow. Immunity 30:721-730.
  5. Tokoyoda K, Zehentmeier S, and Radbruch A. (2009) Organization and maintenance of immunological memory by stroma niches. Eur. J. Immunol. 39:2095-2099.
  6. Tokoyoda K, Hauser AE, Nakayama T, and Radbruch A. (2010) Organization of immunological memory by stroma. Nat. Rev. Immunol. 10:193-200.
  7. Shinoda K*, Tokoyoda K* (*equally contributed), Hanazawa A, Hayashizaki K, Zehentmeier S, Ho-sokawa H, Iwamura C, Koseki H, Tumes DJ, Radbruch A, and Nakayama T. (2012) Type II membrane protein CD69 regulates the formation of resting T helper memory. Proc. Natl. Acad. Sci. USA 109:7409-7414.
  8. Hanazawa A, Hayashizaki K, Shinoda K, Yagita H, Okumura K, Löhning M, Hara T, Taniichi S, Ikuta K, Eckes B, Radbruch A, Tokoyoda K*, and Nakayama T* (*equally contributed). (2013) CD49b-dependent establishment of T helper cell memory. Immunol. Cell Biol. 91:524-531.
  9. Hanazawa A, Löhning M, Radbruch A, and Tokoyoda K. (2013) CD49b/CD69-dependent generation of resting T helper cell memory. Front. Immunol. 4:183.
  10. Hojyo S, Sarkander J, Männe C, Mursell M, Hanazawa A, Zimmel D, Zhu J, Paul WE, Fillatreau S, Löhning M, Radbruch A, andTokoyoda K. (2016) B cells negatively regulate the establishment of CD49b+T-bet+ resting memory T helper cells in the bone marrow. Front. Immunol. 7:26.
  11. Hayashizaki K*, Kimura MY*, Tokoyoda K* (*equally contributed), Hosokawa H, Shinoda K, Hirahara K, Ichikawa T, Onodera A, Hanazawa A, Iwamura C, Kakuta J, Muramoto K, Motohashi S, Tumes DJ, Iinuma T, Yamamoto H, Ikehara Y, Okamoto Y, and Nakayama T. (2016) Myosin light chain 9 and 12 are functional ligands for CD69 that regulate airway inflammation. Science Immunolology. 1:eaaf9154.
  12. Sarkander J, Hojyo S, andTokoyoda K. (2016) Vaccination to gain humoral immune memory. Clin. Transl. 5:e120.
  13. Männe C, Takaya A, Yamasaki Y, Mursell M, Hojyo S, Wu TY, Sarkander J, McGrath MA, Cornelis R, Hahne S, Cheng Q, Kawamoto T, Hiepe F, Kaufmann SHE, Yamamoto T, Radbruch A, andTokoyoda K. (2019) Salmonella SiiE prevents an efficient humoral immune memory by interfering with IgG+ plasma cell persistence in the bone marrow. Proc. Natl. Acad. Sci. 116:7425-7430.
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