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Allergologie
Prof. Dr. med. Margitta Worm

Allergologie

Prof. Dr. med. Margitta Worm

Allergie-Centrum-Charité
Klinik für Dermatologie, Venerologie und Allergologie
Charité Campus Mitte, Universitätsmedizin Berlin
Charitéplatz 1
10117 Berlin
Tel: +49 (0)30 450 518 105 Fax: +49 (0)30 450 518 958 margitta.worm@charite.de
AG Worm
Irrwege des Immunsystems verstehen und korrigieren

CV and Key Publications

Scientific Career
  • 2017 Director Division of Allergy and Immunology
  • 2012 – 2017 Director of outpatient clinic Dpt. Dermatology and Allergy
  • 2011 Coordinator for medical teaching and faculty member for medical education
  • 2007 Study coordinator in clinical trials; coordinating center for clinical studies Charité
  • 2003 Head of the clinical study unit allergy, Department of Dermatology and Allergy
  • 2003 Full professorship for immune modulation of allergic diseases Charité, Berlin
  • 2002 Board certification Allergy & Environmental Medicine
  • 2000 Assistant professor Dpt. Dermatology and Allergy Charité, Berlin
  • 1998 Board certification Dermatology and Venerology
  • 1995 – 2000 Clinical fellow in training Dpt. of Dermatology Charité, Berlin
  • 1993 – 1995 Postdoc research fellow at Children’s Hospital, Havard Medical School, Boston/USA
  • 1991 – 1993 Junior doctor and research fellow at Dpt. of Dermatology, FU-Berlin
  • 1991 Medical graduation at Freie Universität Berlin
Boards and Memberships
  • President of the Deutsche Gesellschaft für Allergologie und Klinische Immunologie (DGAKI)
  • Leader of food allergy group of Deutsche Gesellschaft für Allergologie und klinische Immunologie (DGAKI)
  • 2017 – 2019, chair in food allergy interest group of European Academy of Asthma, Allergy and Immunology (EAACI)
  • President of Network for Online-Registration of Anaphylaxis (NORA e.V)
  • Member of Anaphylaxis Training and Education (AGATE e.V.) Reviewer for German-Research Foundation (DFG)
  • Reviewer for JACI, Allergy, Clin Exp Allergy and others
Awards
  • 2011 Kanert award by Kanert foundation for research in Allergy
  • 2007 Award for pain research „Classical conditioning and expectancy in placebo hypoalgesia
Third Party Funding

Selection from 2011 – ongoing

  • 2020 – 2023 DFG WO 541/19-1 Food@ – KFG339
  • 2015 – 2018 DFG WO 541/13-2 „Cellular and molecular mechanisms of TNF (tumor necrosis factor- alpha) mediated protection in atopic dermatitis“
  • 2015 – 2018 DFG WO 541/16-1 „Cyclooxygenasen als Modulatoren allergischer Reaktionen, mechanistische Hintergründe und therapeutisches Potential“
  • 2013 – 2017 DFG TRR-130 TP 19 „Regulation der B-Zelldifferenzierung durch Vitamin A und D“
  • 2017 – 2021 DFG TRR-130 TP 19 „Regulation der B-Zelldifferenzierung durch Vitamin A und D“
  • 2013 – 2017 DFG WO 541/14-1 “Nutzen des Placeboeffektes bei atopischer Dermatitis – Steigerung der pharmakologischen Wirkung bei Juckreiz durch Konditionierungs- und Erwartungsprozesse“
  • 2012 – 2015 DFG WO 541/13-1 “Cellular and molecular mechanisms of TNF (tumor necrosis factor- alpha)mediated protection in atopic dermatitis“
  • 2013 – 2016 DFG SFB 650 TP 5 „Immunmodulation allergischer Erkrankungen durch nukleäre Hormonrezeptorliganden”
Key Publications
  1. Worm M; Higenbottam T; Pfaar O; Mösges R; Aberer W; Gunawardena K; Wessiepe D; Lee D; Kramer MF; Skinner M; Lees B; Zielen S (2018). Randomized controlled trials define shape of dose response for Pollinex Quattro Birch allergoid immunotherapy. Allergy. Sep;73(9):1812-1822.
  2. Kettner A; DellaCorte G; de Blay F; Jacobsen L; Jutel M; Worm M; Charlon V; Simonsen K; Reymond C; Spertini F (2018). Benefit of Bet v 1 contiguous overlapping peptide immunotherapy persists during first follow-up season. J Allergy Clin Immunol. Aug;142(2):678-680.e7.
  3. Muraro A; Fernandez-Rivas M; Beyer K; Cardona V; Clark A; Eller E; Hourihane JO; Jutel M; Sheikh A; Agache I; Allen KJ; Angier E; Ballmer-Weber B; Bilò MB; Bindslev-Jensen C; Camargo CA Jr; Cianferoni A; DunnGalvin A; Eigenmann PA; Halken S; Hoffmann-Sommergruber K; Lau S; Nilsson C; Poulsen LK; Rueff F; Spergel J; Sturm G; Timmermans F; Torres MJ; Turner P; van Ree R; Wickman M; Worm M; Mills ENC; Roberts G (2018). The urgent need for a harmonized severity scoring system for acute allergic reactions. Allergy. Sep;73(9):1792-1800.
  4. Worm M; Higenbottam T; Pfaar O; Mösges R; Aberer W; Gunawardena K; Wessiepe D; Lee D; Kramer MF; Skinner M; Lees B; Zielen S (2018). Randomized controlled trials define shape of dose response for Pollinex Quattro Birch allergoid immunotherapy. Allergy. Sep;73(9):1812-1822.
  5. Heine G; Hollstein T; Treptow S; Radbruch A; Worm M. (2018). 9-cis retinoic acid modulates the type I allergic immune response. J Allergy Clin Immunol. Feb;141(2):650-658.e5.
  6. Grabenhenrich LB; Dölle S; Ruëff F; Renaudin JM; Scherer K; Pföhler C; Treudler R; Koehli A; Mahler V; Spindler T; Lange L; Bilò MB; Papadopoulos NG; Hourihane JOB; Lang R; Fernández-Rivas M; Christoff G; Cichocka-Jarosz E; Worm M (2018). Epinephrine in Severe Allergic Reactions: The European Anaphylaxis Register. J Allergy Clin Immunol Pract. Mar 29.
  7. Kettner A; DellaCorte G; de Blay F; Jacobsen L; Jutel M; Worm M; Charlon V; Simonsen K; Reymond C; Spertini F (2018). Benefit of Bet v 1 contiguous overlapping peptide immunotherapy persists during first follow-up season. J Allergy Clin Immunol. Aug;142(2):678-680.e7.
  8. Worm M; Scherer K; Köhli-Wiesner A; Ruëff F; Mahler V; Lange L; Treudler R; Rietschel E; Szepfalusi Z; Lang R; Rabe U; Reese T; Schwerk N; Beyer K; Hompes S; Bircher A; Przybilla B; Hawranek T; Hansen G; Friedrichs F; Merk H; Tenbrock K; Lehmann S; Gerstlauer M; Kleine-Tebbe J; Niggemann B; Dickel H; Bücheler M; Bieber T; Hanfland J; Schmitt-Grohe S; Vlajnic D; Heckmann V; Nemat K; Schäkel K; Nordwig A; Schuster A; Schweitzer-Krantz S; Hillen U; Kopp M; Szliska C; Klinge J; Neustädter I; Fuchs T; Bruns R; Marsch C; Kreft B; Coors E; Rebien W; Wedi B; Pföhler C; Rett M; Henzgen M; Vöhringer P; Fölster-Holst R; Hunzelmann N; Siebenhaar G; Nestoris S; Schirpke C; Grabbe J; Stichtenoth G; Ring J; Brockow K; Brehler R; Yildiz I; Volkmuth S; Geißler M; Polz M; Riffelmann F; Thies S; Lepp U; Rabe U; Rebmann H; Spindler T; Klimek L; Pfaar O; Brosi W; Aberer W; Varga E; Reider N; Huttegger I; Kinaciyan T; Hoffmann-Sommergruber K; Eng P; Helbling A; Eigenmann P; Guggenheim R; Schmid-Grendelmeier P (2017). Food-induced anaphylaxis and cofactors – data from the anaphylaxis registry. Allergol Select. 2017 Aug 4;1(1):21-27.
  9. Heratizadeh A; Werfel T; Wollenberg A; Abraham S; Plank-Habibi S; Schnopp C; Sticherling M; Apfelbacher C; Biedermann T; Breuer K; Fell I; Fölster-Holst R; Heine G; Grimm J; Hennighausen L; Kugler C; Reese I; Ring J; Schäkel K Schmitt J; Seikowski K; von Stebut E; Wagner N; Waßmann-Otto A; Wienke-Graul U; Weisshaar E; Worm M; Gieler U; Kupfer J; Arbeitsgemeinschaft Neurodermitisschulung für Erwachsene (ARNE) Study Group (2017). Effects of structured patient education in adults with atopic dermatitis: Multicenter randomized controlled trial. J Allergy Clin Immunol. Sep;140(3):845-853.e3.
  10. Grabenhenrich LB; Dölle S; Moneret-Vautrin A; Köhli A; Lange L; Spindler T; Ruëff F; Nemat K; Maris I; Roumpedaki E; Scherer K; Ott H; Reese T; Mustakov T; Lang R; Fernandez-Rivas M; Kowalski ML; Bilò MB; Hourihane JO; Papadopoulos NG; Beyer K; Muraro A; Worm M (2016). Anaphylaxis in children and adolescents: The European Anaphylaxis Registry. J Allergy Clin Immunol. Apr;137(4):1128-1137.
  11. Nassiri M; Eckermann O; Babina M; Edenharter G, Worm M (2016). Serum levels of 9α,11β-PGF2 and cysteinyl leukotrienes are useful biomarkers of anaphylaxis. J Allergy Clin Immunol. Jan;137(1):312-4.
  12. Spertini F; DellaCorte G; Kettner A; de Blay F; Jacobsen L; Jutel M; Worm M; Charlon V; Reymond C (2016). Efficacy of 2 months of allergen-specific immunotherapy with Bet v 1-derived contiguous overlapping peptides in patients with allergic rhinoconjunctivitis: Results of a phase IIb study. J Allergy Clin Immunol. Jul;138(1):162-8.
  13. Francuzik W; Nassiri M; Babina M; Worm M (2015). Impact of sex on anaphylaxis severity–data from the Anaphylaxis Registry. J Allergy Clin Immunol. Nov;136(5):1425-6.
  14. Nassiri M; Babina M; Dölle S; Edenharter G; Ruëff F; Worm M (2015). Ramipril and metoprolol intake aggravate human and murine anaphylaxis: evidence for direct mast cell priming. J Allergy Clin Immunol. 135(2):491-9.
  15. Heine G; Tabeling C; Hartmann B; Calera G; Carla R; Kühl A; Lindner J; Radbruch A; Witzenrath M; Worm M (2014). 25-Hydroxvitamin D3 Promotes the Long-Term Effect of Specific Immunotherapy in a Murine Allergy Model. J Immunol, 193(3):1017-23.
  16. Bergmann KC; Demoly P; Worm M; Fokkens WJ; Carrilo T; Tabar AI; Nguyen H; Montagut A; Zeldin RK (2014). Efficacy and safety of sublingual tablets of house dust mite allergen extracts in adults with allergic rhinitis. J Allergy Clin Immunol. 133(6):1608-1614.e6.