Alexander Beller: Microbiota analysis in health and disease
Thursday, 7 February 2019 || Time: 14:00
Microbiota analysis in health and disease
The human intestine is colonized by numerous microorganisms. The human intestinal microbiota consists of 300-1000 different microbial species and contains about 1013 individual bacteria. This is comparable with the number of eukaryotic cells in a human’s body.
The ability of gut microbiota to interact with and to activate the host immune system is extensively described. In addition, recent studies describe that certain gut microbiota or its metabolites can influence different, non-mucosal parts of human body. In particular, the correlations between microbiota composition and autoimmune or cardiovascular diseases, or even psychiatric disorders were described in human and mice.
The current studies of microbiota make use of a variety of different methods which all have pros and contras. In our lab we use in first line high-resolution microbiota flow cytometry which provides us a non-invasive, fast and efficient diagnostic tool to visualize dramatic changes of microbiota composition in inflammatory diseases. This method, combined with 16S rDNA sequencing and fluorescence in situ hybridization, allows us to analyze the microbiota fast and efficiently, and isolate distinct bacteria for functional and molecular analyses.
Campus-Lecture Series on Chronic Inflammatory Diseases
Chronic Inflammatory Diseases are a major health issue without satisfactory treatment despite decades of research. In this lecture series, postdoctoral researchers associated with the Leibniz WissenschaftsCampus Berlin, will present their research areas and perspectives spanning state-of-the-art experimental methods, cellular mechanisms of chronic inflammation, novel therapeutic approaches and drug discovery. The aim is to share experiences, ideas and concepts thereby increasing interest in the complex field of chronic inflammatory diseases among advanced Master’s students and PhD students in all related subjects.
when: 14:00-15:00, weekly, every Thursday
where: DRFZ, Seminar room 3, Charitéplatz 1
visitors: Virchowweg 12
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• Are you familiar with chronic inflammatory diseases?
• Have you heard that any organ can be affected?
• Joints, skin, kidneys, nerves, intestines – all?
• understand one inflammatory disease – cure them all?
…. these and further topics will be covered in the new Lecture Series given by our Postdoc Fellows.
miRNA +++ drug discovery +++ imaging +++ cancer +++ RNA-based gene regulation +++ immune checkpoints as therapeutic targets +++ T cells +++ mass cytometry ++ plasma cell targeting +++ RA and cardiovascular disease +++ optical ethods +++ stromal niches
Stefan Frischbutter +++ Patrick Maschmeyer +++ Randall Lindquist +++ Gitta Heinz +++ Marina Babic-Cac +++ Shintaro Hoyjo +++ Axel Schulz +++ Laleh Khodadadi +++ Yvette Meissner +++ Asylkhan Rakhymzhan +++ Daniel Schulz
In the ScienceCampus we aim at transferring research and therapeutic concepts from one disease to another – across disciplines – for a fast translation into the clinic.