Gitta Heinz: RNA-based gene regulation in chronic inflammation
Thursday, 8 November 2018 || Time: 14:00
This lecture will give an overview on gene regulatory mechanisms that play an important role in establishing and maintaining chronic inflammation and that are driven by RNA molecules. These are on the one hand miRNAs, which modulate gene expression by directly binding to their target mRNAs and promoting translational repression or degradation. Other non-coding RNAs were also described to be involved in inflammatory processes, even though their molecular functions are not fully understood. On the other hand the translation and stability of mRNA molecules, particularly cytokine mRNAs, is tightly regulated via sequence elements within the 3’ untranslated region. As an outlook, novel diagnostic and therapeutic approaches that make use of the above-mentioned mechanisms will be discussed.
when: 14:00-15:00, weekly, every Thursday
where: DRFZ, Seminar room 3, Charitéplatz 1
visitors: Virchowweg 12
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• Are you familiar with chronic inflammatory diseases?
• Have you heard that any organ can be affected?
• Joints, skin, kidneys, nerves, intestines – all?
• understand one inflammatory disease – cure them all?
…. these and further topics will be covered in the new Lecture Series given by our Postdoc Fellows.
miRNA +++ drug discovery +++ imaging +++ cancer +++ RNA-based gene regulation +++ immune checkpoints as therapeutic targets +++ T cells +++ mass cytometry ++ plasma cell targeting +++ RA and cardiovascular disease +++ optical ethods +++ stromal niches
Stefan Frischbutter +++ Patrick Maschmeyer +++ Randall Lindquist +++ Gitta Heinz +++ Marina Babic-Cac +++ Shintaro Hoyjo +++ Axel Schulz +++ Laleh Khodadadi +++ Yvette Meissner +++ Asylkhan Rakhymzhan +++ Daniel Schulz
In the ScienceCampus we aim at transferring research and therapeutic concepts from one disease to another – across disciplines – for a fast translation into the clinic.