Laleh Khodadadi : Targeting Plasma cells
Secreted antibodies that are directed against specific infectious pathogens are an essential component of the immune system and provide efficient protection against recurrent infections. If immunological tolerance fails, secreted antibodies specific for autoantigens, alloantigens, or allergens can cause chronic inflammatory diseases such as autoimmune disorders, transplanted organ rejection or allergies. This plethora of several hundred different clinical disease entities affects more than 10% of the human population. Plasma cells secreting pathogenic antibodies are a key deriver of chronic inflammation. Therefore, they have become a very promising candidate target for treating antibody-mediated diseases. In this lecture the novel therapies targeting plasma cells will be discussed.
when: 14:00-15:00, weekly, every Thursday
where: DRFZ, Seminar room 3, Charitéplatz 1
visitors: Virchowweg 12
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• Are you familiar with chronic inflammatory diseases?
• Have you heard that any organ can be affected?
• Joints, skin, kidneys, nerves, intestines – all?
• understand one inflammatory disease – cure them all?
…. these and further topics will be covered in the new Lecture Series given by our Postdoc Fellows.
miRNA +++ drug discovery +++ imaging +++ cancer +++ RNA-based gene regulation +++ immune checkpoints as therapeutic targets +++ T cells +++ mass cytometry ++ plasma cell targeting +++ RA and cardiovascular disease +++ optical ethods +++ stromal niches
Stefan Frischbutter +++ Patrick Maschmeyer +++ Randall Lindquist +++ Gitta Heinz +++ Marina Babic-Cac +++ Shintaro Hoyjo +++ Axel Schulz +++ Laleh Khodadadi +++ Yvette Meissner +++ Asylkhan Rakhymzhan +++ Daniel Schulz
In the ScienceCampus we aim at transferring research and therapeutic concepts from one disease to another – across disciplines – for a fast translation into the clinic.