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Home > People at the DRFZ > Prof. Dr. Andreas Diefenbach

Prof. Dr. Andreas Diefenbach

Programme Area 1, PA 1 – Cell and Tissue Rheumatology

Group leader: Developmental and Mucosal Immunology

Liaison working group with Charité - Microbiology, Infectious Diseases and Immunology,

+49 30 450 524 171

andreas.diefenbach@charite.de

Scientific Background

Since 2021
Chief Scientific Officer (CSO), Labor Berlin

Since 2018
Professor, Freie Universität Berlin, Department Biology, Chemistry and Pharmacy

Since 2016
Professor (W3) and Director/Chair, Institute of Microbiology, Infectious Diseases and Immunology, Charité – University Medical Centre Berlin, Laboratory Head, Developmental and Mucosal Immunology, German Rheumatism Research Centre, A Leibniz Institute, Berlin, Director, Fachbereich Mikrobiologie und Hygiene, Labor Berlin

2013 – 2016
Professor (W3) and Director/Chair, Institute of Medical Microbiology and Hygiene, Johannes-Gutenberg University of Mainz

2007 – 2013
Professor (W3, tenured), Mikrobiologie & Molekulare Infektionsimmunologie, University of Freiburg, Medical Centre

2007 – 2010
Adjunct Professor of Pathology, Department of Pathology, New York University MedicalCenter, New York, USA

2003 – 2007
Irene Diamond Assistant Professor of Immunology (tenure track), Assistant Professor of Pathology, Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York, USA

1999 – 2003
Postdoctoral Fellow, Department of Molecular & Cell Biology, University of California, Berkeley, USA

1996 – 1998
Resident, Institut für Klinische Mikrobiologie, Immunologie & Hygiene, University of Erlangen

2012
Board Exam (Facharztprüfung), Microbiology, Virology and Epidemiology of Infections (Mikrobiologie, Virologie und Infektionsepidemiologie)

1997
Dr. med. (summa cum laude), Microbiology/Immunology, U Erlangen

1996
M.D., Medicine, University of Erlangen

1989 – 1996
Medical School, University Of Erlangen, Germany and Imperial College, London, UK

Since 2022
Spokesperson, The Berlin Centre for the Biology of Health

Since 2021
Spokesperson, Graduate School “Re-Thinking Health” (Else Kröner-Fresenius Foundation)

Since 2017
Vertrauensdozent, Studienstiftung des Deutschen Volkes

2016 – 2022
Spokesperson, DFG Priority Program 1937 “Innate Lymphoid Cells”

2015 – 2016
Speaker, Research Centre Immunology, Universitätsmedizin Mainz

2014 – 2016
Steering Committee, International PhD Program of Institute of Molecular Biology (IMB) and University of Mainz

Amercian Association of Immunologists, German Association of Immunologists, German Society of Hygiene and Microbiology, Society of Natural Immunity

2022
ERC Advanced Grant

2019-2022
Visiting Professor, Chiba University, Chiba, Japan

2018
Elected Member, Berlin-Brandenburg Academy of Sciences

since 2017
Clarivate Highly Cited Researcher

2013
ERC Starting/Consolidator Grant

2010
Main Scientific Prize, Deutsche Gesellschaft für Mikrobiologie und Hygiene

2009
Kavli Fellow, National Academy of Sciences USA & Alexander-Von-Humboldt-Stiftung

2004
Whitehead Fellowship for Junior Faculty in Biomedical Sciences

2003
Irene Diamond Professorship for Immunology

2000
Postdoctoral Fellowship for Physicians, Howard Hughes Medical Institute

1999
Postdoctoral Fellowship, Deutsche Forschungsgemeinschaft

TOP 5 PUBLICATIONS

Amplification of autoimmune organ damage by NKp46-activated ILC1s Biniaris-Georgallis SI, Aschman T, Stergioula K, Schreiber F, Jafari V, Taranko A, Karmalkar T, Kasapi A, Rovis Tl, Jelencic V, Bejarano D, Fabry L, Mattiola I, Molgora M, Hou J, Hublitz Kw, Heinrich F, Guerra GM, Durek P, Patone G, Lindberg ELH, Maatz H, Hölsken O, Krönke G, Mortha A, Voll RE, Clarke AJ, Hauser AE, Colonna M, Thurley K, Schlitzer A, Schneider C, Stamatiades EG, Mashreghi MF, Jonjic S, Hübner N, Diefenbach A*, Kanda M*, and Triantafyllopoulou A*. 2024. NKp46-activated ILC1 amplify autoimmune organ damage by programming disease-associated macrophages. Nature, published online Aug 13, 2024. *Corresponding/Senior Authors (equal contribution)
Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells Witkowski M, Tizian C, Ferreira-Gomes M, Niemeyer D, Jones TC, Heinrich F, Frischbutter S, Angermair S, Hohnstein T, Mattiola I, Nawrath P, McEwen S, Zocche S, Viviano E, Heinz GA, Maurer M, Kölsch U, Chua RL, Aschman T, Meisel C, Radke J, Sawitzki B, Roehmel J, Allers K, Moos V, Schneider T, Hanitsch L, Mall MA, Conrad C, Radbruch H, Duerr CU, Trapani JA, Marcenaro E, Kallinich T, Corman VM, Kurth F, Sander LE, Drosten C, Treskatsch S, Durek P, Kruglov A, Radbruch A, Mashreghi MF, Diefenbach A. Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells. Nature. 2021. 600:295-301. doi: 10.1038/s41586-021-04142-6.
Group 3 Innate Lymphoid Cells Program a Distinct Subset of IL-22BP-Producing Dendritic Cells Demarcating Solitary Intestinal Lymphoid Tissues Guendel F, Kofoed-Branzk M, Gronke K, Tizian C, Witkowski M, Cheng HW, Heinz GA, Heinrich F, Durek P, Norris PS, Ware CF, Ruedl C, Herold S, Pfeffer K, Hehlgans T, Waisman A, Becher B, Giannou AD, Brachs S, Ebert K, Tanriver Y, Ludewig B, Mashreghi MF, Kruglov AA, Diefenbach A. Group 3 Innate Lymphoid Cells Program a Distinct Subset of IL-22BP-Producing Dendritic Cells Demarcating Solitary Intestinal Lymphoid Tissues. Immunity. 2020. 53:1015-1032.e8. doi: 10.1016/j.immuni.2020.10.012.
Microbiota-Induced Type I Interferons Instruct a Poised Basal State of Dendritic Cells Schaupp L, Muth S, Rogell L, Kofoed-Branzk M, Melchior F, Lienenklaus S, Ganal-Vonarburg SC, Klein M, Guendel F, Hain T, Schütze K, Grundmann U, Schmitt V, Dorsch M, Spanier J, Larsen PK, Schwanz T, Jäckel S, Reinhardt C, Bopp T, Danckwardt S, Mahnke K, Heinz GA, Mashreghi MF, Durek P, Kalinke U, Kretz O, Huber TB, Weiss S, Wilhelm C, Macpherson AJ, Schild H, Diefenbach A*,1, Probst HC*. Microbiota-Induced Type I Interferons Instruct a Poised Basal State of Dendritic Cells. Cell. 2020. 181:1080-1096.e19. doi: 10.1016/j.cell.2020.04.022. *Corresponding/Senior Authors (equal contribution), 1Lead Author
Interleukin-22 protects intestinal stem cells against genotoxic stress Gronke K, Hernández PP, Zimmermann J, Klose CSN, Kofoed-Branzk M, Guendel F, Witkowski M, Tizian C, Amann L, Schumacher F, Glatt H, Triantafyllopoulou A, Diefenbach A. Interleukin-22 protects intestinal stem cells against genotoxic stress. Nature. 2019. 566:249-253. doi: 10.1038/s41586-019-0899-7.

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