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Dr. Andrey Kruglov

Programme Area 3, PA 3 – Systems Rheumatology

Group leader: Chronic Inflammation

+49 (0)30 28460-641/643

kruglov@drfz.de

Scientific Background

Since 2016
Group Leader at DRFZ, Berlin, Germany

2013-2022
Leading Staff Scientist at A.N. Belozersky Institute of Physico-chemical Biology, M.V. Lomonosov Moscow State University, Moscow, Russia

2015-2016
Guest Scientist at DRFZ, Berlin, Germany

2009-2015
Postdoctoral Scientist at DRFZ, Berlin, Germany

2004-2009
PhD in Biology, Engelhardt Insitute of Molecular Biology, Moscow, Russia

1999-2004
Master of Science in Chemistry, Chemistry Department, M.V. Lomonosov Moscow State University, Msocow, Russia

Since 2022
Organisation of B cell seminar at DRFZ

2022-2024
Ad-hoc reviewer for Gut Microbes, Gastroenterology, cellular immunology and etc.

2022-2024
Reviewer of grant proposal for CNRS and SNSF

Since 2012
Member of German Society of Immunology (DGFI)

2021
Leibniz Research Alliance Bioactive Compounds and Biotechnology: “Identification of protein structures resembling RBD of SARS-CoV-2 by human commensal microrganisms” PI: Andrey Kruglov and Co-PI: Jorg Overmann.

TOP PUBLICATIONS

Recruitment of plasma cells from IL-21-dependent and IL-21-independent immune reactions to the bone marrow Ferreira-Gomes M, Chen Y, Durek P, Rincon-Arevalo H, Heinrich F, Bauer L, Szelinski F, Guerra GM, Stefanski AL, Niedobitek A, Wiedemann A, Bondareva M, Ritter J, Lehmann K, Hardt S, Hipfl C, Hein S, Hildt E, Matz M, Mei HE, Cheng Q, Dang VD, Witkowski M, Lino AC, Kruglov A, Melchers F, Perka C, Schrezenmeier EV, Hutloff A, Radbruch A, Dörner T, Mashreghi MF. Recruitment of plasma cells from IL-21-dependent and IL-21-independent immune reactions to the bone marrow. Nat Commun. 2024 May 17;15(1):4182. doi: 10.1038/s41467-024-48570-0. PMID: 38755157; PMCID: PMC11099182.
Cross-regulation of antibody responses against the SARS-CoV-2 Spike protein and commensal microbiota via molecular mimicry Bondareva M, Budzinski L, Durek P, Witkowski M, Angermair S, Ninnemann J, Kreye J, Letz P, Ferreira-Gomes M, Semin I, Guerra GM, Momsen Reincke S, Sánchez-Sendin E, Yilmaz S, Sempert T, Heinz GA, Tizian C, Raftery M, Schönrich G, Matyushkina D, Smirnov IV, Govorun VM, Schrezenmeier E, Stefanski AL, Dörner T, Zocche S, Viviano E, Klement N, Sehmsdorf KJ, Lunin A, Chang HD, Drutskaya M, Kozlovskaya L, Treskatsch S, Radbruch A, Diefenbach A, Prüss H, Enghard P, Mashreghi MF, Kruglov AA. Cross-regulation of antibody responses against the SARS-CoV-2 Spike protein and commensal microbiota via molecular mimicry. Cell Host Microbe. 2023 Nov 8;31(11):1866-1881.e10. doi: 10.1016/j.chom.2023.10.007. PMID: 37944493.
Induction of cross-reactive, mucosal anti-SARS-CoV-2 antibody responses in rheumatoid arthritis patients after 3rd dose of COVID-19 vaccination Bondareva M, Letz P, Karberg K, Schrezenmeier E, Semin I, Rincon-Arevalo H, Dörner T, Mashreghi MF, Stefanski AL, Kruglov AA. Induction of cross-reactive, mucosal anti-SARS-CoV-2 antibody responses in rheumatoid arthritis patients after 3rd dose of COVID-19 vaccination. J Autoimmun. 2022 Dec;133:102918. doi: 10.1016/j.jaut.2022.102918. Epub 2022 Oct 11. PMID: 36228431; PMCID: PMC9550527.
TNF hampers intestinal tissue repair in colitis by restricting IL-22 bioavailability Ninnemann J, Winsauer C, Bondareva M, Kühl AA, Lozza L, Durek P, Lissner D, Siegmund B, Kaufmann SHE, Mashreghi MF, Nedospasov SA, Kruglov AA. TNF hampers intestinal tissue repair in colitis by restricting IL-22 bioavailability. Mucosal Immunol. 2022 Apr;15(4):698-716. doi: 10.1038/s41385-022-00506-x. Epub 2022 Apr 5. PMID: 35383266; PMCID: PMC9259490.
The fecal mycobiome in non-alcoholic fatty liver disease Demir M, Lang S, Hartmann P, Duan Y, Martin A, Miyamoto Y, Bondareva M, Zhang X, Wang Y, Kasper P, Bang C, Roderburg C, Tacke F, Steffen HM, Goeser T, Kruglov A, Eckmann L, Stärkel P, Fouts DE, Schnabl B. The fecal mycobiome in non-alcoholic fatty liver disease. J Hepatol. 2022 Apr;76(4):788-799. doi: 10.1016/j.jhep.2021.11.029. Epub 2021 Dec 10. PMID: 34896404; PMCID: PMC8981795.
Contrasting contributions of TNF from distinct cellular sources in arthritis Kruglov, A., Drutskaya, M., Schlienz, D., Gorshkova, E., Kurz, K., Morawietz, L., & Nedospasov, S. (2020). Contrasting contributions of TNF from distinct cellular sources in arthritis. Ann Rheum Dis, 79(11), 1453-1459. https://doi.org/10.1136/annrheumdis-2019-216068
Nonredundant function of soluble LTalpha3 produced by innate lymphoid cells in intestinal homeostasis Kruglov, A. A*., Grivennikov, S. I., Kuprash, D. V., Winsauer, C., Prepens, S., Seleznik, G. M., Eberl, G., Littman, D. R., Heikenwalder, M., Tumanov, A. V., & Nedospasov, S. A. (2013). Nonredundant function of soluble LTalpha3 produced by innate lymphoid cells in intestinal homeostasis. Science, 342(6163), 1243-1246. https://doi.org/10.1126/science.1243364. * corresponding author

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