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Dr. Andrey Kruglov

Programme Area 3, PA 3 – Systems Rheumatology

Group leader: Chronic Inflammation

+49 (0)30 28460-641/643

kruglov@drfz.de

Scientific Background

Since 2016rnGroup Leader at DRFZ, Berlin, Germanyrnrn2013-2022rnLeading Staff Scientist at A.N. Belozersky Institute of Physico-chemical Biology, M.V. Lomonosov Moscow State University, Moscow, Russiarnrn2015-2016rnGuest Scientist at DRFZ, Berlin, Germanyrnrn2009-2015rnPostdoctoral Scientist at DRFZ, Berlin, Germany

2004-2009rnPhD in Biology, Engelhardt Insitute of Molecular Biology, Moscow, Russiarnrn1999-2004rnMaster of Science in Chemistry, Chemistry Department, M.V. Lomonosov Moscow State University, Msocow, Russia

Since 2022rnOrganisation of B cell seminar at DRFZrnrn2022-2024rnAd-hoc reviewer for Gut Microbes, Gastroenterology, cellular immunology and etc.rnrn2022-2024rnReviewer of grant proposal for CNRS and SNSF

Since 2012rnMember of German Society of Immunology (DGFI)

2021rnLeibniz Research Alliance Bioactive Compounds and Biotechnology: “Identification of protein structures resembling RBD of SARS-CoV-2 by human commensal microrganisms” PI: Andrey Kruglov and Co-PI: Jorg Overmann.

TOP 5 PUBLICATIONS

Recruitment of plasma cells from IL-21-dependent and IL-21-independent immune reactions to the bone marrow Ferreira-Gomes M, Chen Y, Durek P, Rincon-Arevalo H, Heinrich F, Bauer L, Szelinski F, Guerra GM, Stefanski AL, Niedobitek A, Wiedemann A, Bondareva M, Ritter J, Lehmann K, Hardt S, Hipfl C, Hein S, Hildt E, Matz M, Mei HE, Cheng Q, Dang VD, Witkowski M, Lino AC, Kruglov A, Melchers F, Perka C, Schrezenmeier EV, Hutloff A, Radbruch A, Dörner T, Mashreghi MF. Recruitment of plasma cells from IL-21-dependent and IL-21-independent immune reactions to the bone marrow. Nat Commun. 2024 May 17;15(1):4182. doi: 10.1038/s41467-024-48570-0. PMID: 38755157; PMCID: PMC11099182.
Cross-regulation of antibody responses against the SARS-CoV-2 Spike protein and commensal microbiota via molecular mimicry Bondareva M, Budzinski L, Durek P, Witkowski M, Angermair S, Ninnemann J, Kreye J, Letz P, Ferreira-Gomes M, Semin I, Guerra GM, Momsen Reincke S, Sánchez-Sendin E, Yilmaz S, Sempert T, Heinz GA, Tizian C, Raftery M, Schönrich G, Matyushkina D, Smirnov IV, Govorun VM, Schrezenmeier E, Stefanski AL, Dörner T, Zocche S, Viviano E, Klement N, Sehmsdorf KJ, Lunin A, Chang HD, Drutskaya M, Kozlovskaya L, Treskatsch S, Radbruch A, Diefenbach A, Prüss H, Enghard P, Mashreghi MF, Kruglov AA. Cross-regulation of antibody responses against the SARS-CoV-2 Spike protein and commensal microbiota via molecular mimicry. Cell Host Microbe. 2023 Nov 8;31(11):1866-1881.e10. doi: 10.1016/j.chom.2023.10.007. PMID: 37944493.
Induction of cross-reactive, mucosal anti-SARS-CoV-2 antibody responses in rheumatoid arthritis patients after 3rd dose of COVID-19 vaccination Bondareva M, Letz P, Karberg K, Schrezenmeier E, Semin I, Rincon-Arevalo H, Dörner T, Mashreghi MF, Stefanski AL, Kruglov AA. Induction of cross-reactive, mucosal anti-SARS-CoV-2 antibody responses in rheumatoid arthritis patients after 3rd dose of COVID-19 vaccination. J Autoimmun. 2022 Dec;133:102918. doi: 10.1016/j.jaut.2022.102918. Epub 2022 Oct 11. PMID: 36228431; PMCID: PMC9550527.
TNF hampers intestinal tissue repair in colitis by restricting IL-22 bioavailability Ninnemann J, Winsauer C, Bondareva M, Kühl AA, Lozza L, Durek P, Lissner D, Siegmund B, Kaufmann SHE, Mashreghi MF, Nedospasov SA, Kruglov AA. TNF hampers intestinal tissue repair in colitis by restricting IL-22 bioavailability. Mucosal Immunol. 2022 Apr;15(4):698-716. doi: 10.1038/s41385-022-00506-x. Epub 2022 Apr 5. PMID: 35383266; PMCID: PMC9259490.
The fecal mycobiome in non-alcoholic fatty liver disease 5. Demir M, Lang S, Hartmann P, Duan Y, Martin A, Miyamoto Y, Bondareva M, Zhang X, Wang Y, Kasper P, Bang C, Roderburg C, Tacke F, Steffen HM, Goeser T, Kruglov A, Eckmann L, Stärkel P, Fouts DE, Schnabl B. The fecal mycobiome in non-alcoholic fatty liver disease. J Hepatol. 2022 Apr;76(4):788-799. doi: 10.1016/j.jhep.2021.11.029. Epub 2021 Dec 10. PMID: 34896404; PMCID: PMC8981795.

Kruglov lab

Significance of immune system, cytokines and microbiota interplay for the development of chronic inflammation
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