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Home > People at the DRFZ > Prof. Dr. med. Falk Hiepe

Prof. Dr. med. Falk Hiepe

Autoimmunology

Liaison working group with Charité - Rheumatology and Clinical Immunology

Tel: +49 (0)30 450 513 082

falk.hiepe@charite.de

Senior Scientific Advisor

Scientific Background

Since 2019rnSenior Professor, Charité – Universitätsmedizin Berlinrnrn1997-2019rnFull Professor of Rheumatology and Clinical Immunology, Charité – Universitätsmedizin BerlinrnrnSince 1997rnGroup Leader German Rheumatism Research Centre Berlin, a Leibniz Institute, Autoimmunology Grouprnrn1993-2019rnDeputy Director, Department of Rheumatology and Clin. Immunology, Charité – Universitätsmedizin Berlinrnrn1995rnResearch Fellow, W. M. Keck Autoimmune Disease Center (Head: E.M. Tan), The Scripps Research Institute, La Jolla, CA, USArnrn1988rnCompleted postdoctoral dissertation (habilitation, prerequisite for professorship) at the Humboldt University in Berlinrnrn1987rnVisiting Professor at the Second Dept. of Medicine, Teikyo University and Department of Medicine u0026amp; Physical Therapy (Kazuhiko Yamamoto’s Lab), University of Tokyo, Japanrnrn1977rndegree thesis (Dr. med.), Faculty of Medicine, Humboldt University, Berlin)rnrn1976rnDiploma (Dipl.-Med.), Faculty of Medicine, Humboldt University, Berlin

1994rnSpecialization in Rheumatologyrnrn1983rnSpecialization in Internal Medicinernrn1978-1983rnResident Department of Internal Medicine, Charité Berlin, Germanyrnrn1971-1976rnStudy of Medicine, Humboldt-University Berlin, Germany

Since 2014rnChair,  Deutsche Gesellschaft für Lupus-ForschungrnrnSince 2000rnu003culu003ern tu003cliu003eIUIS/WHO/AF/CDC Committee for the Standardization of Autoantibodies in Rheumatic and Related Diseasesu003c/liu003ern tu003cliu003eInternational Advisory Board of Modern Rheumatology, The Japan Rheumatism Associationu003c/liu003ern tu003cliu003eSpeaker, Arbeitskreis „Extrakorporale Therapieverfahren und Stammzelltherapie“, DGRhu003c/liu003ernu003c/ulu003ern2002-2014rnDrug Commission of the German Medical Association

u003cp class=u0022CV01Introductionu0022u003eThe German Society for Rheumatology, The German Society for Immunology, The Henry Kunkel Society, Deutsche Gesellschaft für Lupus-Forschung, EBMT working party “autoimmune diseases”, Rheuma-Liga Berlin e.V., Gesellschaft für Natur- und Heilkunde in Berlin, Gesellschaft zur Förderung der Immundiagnostik e.V., Freunde und Förderer der Charitéu003c/pu003e

Award Wolfgang-Schulze Foundation, EULAR-award of EWRR, Ideenwettbewerb Deutsche Rheumastiftung,rnrnHumboldt Award for Best Diploma, Research Award Charité Hospital

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TOP 5 PUBLICATIONS

Selective depletion of plasma cells in vivo based on the specificity of their secreted antibodies Cheng, Q., A. Pelz, A. Taddeo, L. Khodadadi, J. Klotsche, B. F. Hoyer, T. Alexander, A. Thiel, G. R. Burmester, A. Radbruch, and F. Hiepe. 2020. Selective depletion of plasma cells in vivo based on the specificity of their secreted antibodies. Eur J Immunol 50: 284-291.
Long-lived autoreactive plasma cells drive persistent autoimmune inflammation Hiepe, F., T. Dörner, A.E. Hauser, B.F. Hoyer, H. Mei, and A. Radbruch. 2011. Long-lived autoreactive plasma cells drive persistent autoimmune inflammation. Nat Rev Rheumatol 7:170-178.
Depletion of autoreactive immunologic memory followed by autologous hematopoietic stem cell transplantation in patients with refractory SLE induces long-term remission through de novo generation of a juvenile and tolerant immune system Alexander, T., A. Thiel, O. Rosen, G. Massenkeil, A. Sattler, S. Kohler, H. Mei, H. Radtke, E. Gromnica-Ihle, G. R. Burmester, R. Arnold, A. Radbruch, and F. Hiepe. 2009. Depletion of autoreactive immunologic memory followed by autologous hematopoietic stem cell transplantation in patients with refractory SLE induces long-term remission through de novo generation of a juvenile and tolerant immune system. Blood 113: 214-223
Short-lived plasmablasts and long-lived plasma cells contribute to chronic humoral autoimmunity in NZB/W mice Hoyer, B. F., K. Moser, A. E. Hauser, A. Peddinghaus, C. Voigt, D. Eilat, A. Radbruch, F. Hiepe*, and R. A. Manz*. 2004. Short-lived plasmablasts and long-lived plasma cells contribute to chronic humoral autoimmunity in NZB/W mice. The Journal of experimental medicine 199: 1577-1584. *contributed equally
A novel epitope on the C-terminus of SmD1 is recognized by the majority of sera from patients with systemic lupus erythematosus. Riemekasten, G., J. Marell, G. Trebeljahr, R. Klein, G. Hausdorf, T. Häupl, J. Schneider-Mergener, G. R. Burmester, and F. Hiepe. 1998. A novel epitope on the C-terminus of SmD1 is recognized by the majority of sera from patients with systemic lupus erythematosus. J Clin Invest 102: 754-763.