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Scientific Director
Prof. Dr. Andreas Radbruch

Scientific Director

Prof. Dr. Andreas Radbruch

Director's Office:
Tanja Durez
Mairi McGrath





Personal Assistant:

Tanja Durez
phone: +49 (0)30 28 460-602
fax: +49 (0)30 28 460-603
durez@drfz.de
Phone: +49 (0)30 28 460-601 Fax: +49 (0)30 28 460-603 durez@drfz.de

CV and Key Publications

Scientific Career
  • Since 1998 Professor (C4S) for Experimental Rheumatology at Charité Universitätsmedizin Berlin
  • Since 1996 Scientific Director of the Leibniz Institute “Deutsches Rheuma-Forschungszentrum”
  • 1990 – 1998 Professor (C3) for Genetics and Immunology, University of Cologne
  • 1988 – 1989 Bayer-Lecturer at the Institute for Genetics of the University of Cologne
  • 1987, 1988 Visiting Scientist at the University of Alabama, Birmingham, with Max Cooper
  • 1982 – 1988 Assistant Professor, Institute for Genetics of the Cologne University
  • 1980 – 1982 Research Assistant at the Institute for Genetics of the Cologne University
Education
  • 1988 Habilitation and Venia Legendi in Genetics and Immunology, University of Cologne
  • 1980 Promotion to Dr. rer. nat., with Klaus Rajewsky, Institute for Genetics of the University of Cologne
  • 1976 Diploma in biology (Dipl. Biol.) at the University of Bonn
Boards
  • Advisory Board of the Institute for Biomedical Sciences (RIBS), Tokyo University of Science
  • Expert Panel (“Fachkollegium”) 201 “Cell Biology”of the DFG (German Research Foundation)
  • Scientific Advisory Board of the Robert-Koch-Foundation
  • Council (Hochschulrat) of the University of Cologne
  • Chair of the Scientific Advisory Board of the Research Institute “Georg Speyer Haus” (Frankfurt/Main)
  • Chair of the Scientific Advisory Board of the Interdisciplinary Center for Clinical Research (IZKF) (Münster)
Scientific Self-Organisation (Selection)
  • 2019 – 2021 President of the European Federation of Immunological Societies (EFIS)
  • Since 2015 Spokesman of Section C (Lifesciences) of the Leibniz Association
  • 2014 – 2016 President of the International Society for Advancement of Cytometry (ISAC)
  • 2012 – 2015 European Journal of Immunology (Chair of the Excecutive Editorial Board)
  • Since 2010 Member of the European Molecular Biology Organization (EMBO)
  • Since 2009 Member of the Berlin-Brandenburg Academy of Sciences (BBAW)
  • 2009 – 2010 President of the German Society for Immunology
  • Since 2009 Member of the German Academy of Sciences (Leopoldina)
  • 2007 – 2008 President of the German Society of Rheumatology
  • 1994 – 1996 President of the German Society of Cytometry
Awards
  • Blondel Medal for Rheumatology (2017)
  • Avery Landsteiner Award (2014)
  • Carol Nachman Prize (2014)
  • ERC Advanced Grant (2011-2016)
  • Federal Cross of Merit of Germany (2008)
  • Aronson Prize (2000)
  • Karl-Heinz Beckurts Prize (Technology Transfer Award) (1994)
Third Party Funding (Selection from 2011 - ongoing)
  • 2018 – 2022 DFG SFB TRR 241
  • 2017 – 2022 EU IMI2 “RTCure” – Lead of WP 3;
  • 2017 – 2021 DFG SFB TRR130
  • 2015 – 2019 BMBF “Neuroimmunology and Pain (NeuroImpa)“
  • 2012 – 2016 DFG SFB 650
  • 2011 – 2017 EU IMI “BTCure”
  • 2011 – 2016 DFG SFB 633
  • 2010 – 2016 DFG SPP 1468 “ImmunoBone”
  • 2010 – 2013 BMBF “Imprinting of pathogenic memory (IMPAM)”
  • 2010 – 2013 BMBF “ImmunoPain“
Key Publications (since 2011)
  1. Chang HD, Tokoyoda K, Radbruch A. Immunological memories of the bone marrow. Immunol Rev. 2018 May; 283(1):86-98. Review
  2. Siracusa F, McGrath MA, Maschmeyer P, Bardua M, Lehmann K, Heinz G, Durek P, Heinrich FF, Mashreghi MF, Chang HD, Tokoyoda K, Radbruch A. Nonfollicular reactivation of bone marrow resident memory CD4 T cells in immune clusters of the bone marrow. Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):1334-1339
  3. Maschmeyer P, Petkau G, Siracusa F, Zimmermann J, Zügel F, Kühl AA, Lehmann K, Schimmelpfennig S, Weber M, Haftmann C, Riedel R, Bardua M, Heinz GA, Tran CL, Hoyer BF, Hiepe F, Herzog S, Wittmann J, Rajewsky N, Melchers FG, Chang HD, Radbruch A, Mashreghi MF. Selective targeting of pro-inflammatory Th1 cells by microRNA-148a-specific antagomirs in vivo. J Autoimmun. 2018 May;89:41-52
  4. Siracusa F, Alp ÖS, Maschmeyer P, McGrath M, Mashreghi MF, Hojyo S, Chang HD, Tokoyoda K, Radbruch A. Maintenance of CD8(+) memory T lymphocytes in the spleen but not in the bone marrow is dependent on proliferation. Eur J Immunol. 2017 Nov;47(11):1900-1905
  5. Zimmermann J, Kühl AA, Weber M, Grün JR, Löffler J, Haftmann C, Riedel R, Maschmeyer P, Lehmann K, Westendorf K, Mashreghi MF, Löhning M, Mack M, Radbruch A, Chang HD. T-bet expression by Th cells promotes type 1 inflammation but is dispensable for colitis. Mucosal Immunol. 2016 Feb 17. doi: 10.1038/mi.2016.5.
  6. Alexander T, Sarfert R, Klotsche J, Kühl AA, Rubbert-Roth A, Lorenz HM, Rech J, Hoyer BF, Cheng Q, Waka A, Taddeo A, Wiesener M, Schett G, Burmester GR, Radbruch A, Hiepe F, Voll RE. The proteasome inhibitior bortezomib depletes plasma cells and ameliorates clinical manifestations of refractory systemic lupus erythematosus. Ann Rheum Dis. 2015 Jul;74(7):1474-8
  7. Haftmann C, Stittrich AB, Zimmermann J, Fang Z, Hradilkova K, Bardua M, Westendorf K, Heinz GA, Riedel R, Siede J, Lehmann K, Weinberger EE, Zimmel D, Lauer U, Häupl T, Sieper J, Backhaus M, Neumann C, Hoffmann U, Porstner M, Chen W, Grün JR, Baumgrass R, Matz M, Löhning M, Scheffold A, Wittmann J, Chang HD, Rajewsky N, Jäck HM, Radbruch A*, Mashreghi MF*. miR-148a is upregulated by Twist1 and T- bet and promotes Th1-cell survival by regulating the proapoptotic gene Bim. Eur J Immunol. 2015 Apr;45(4):1192-205., *equal contribution
  8. Okhrimenko, A., Grun, J.R., Westendorf, K., Fang, Z., Reinke, S., von Roth, P., Wassilew, G., Kuhl, A.A., Kudernatsch, R., Demski, S., Scheibenbogen, C., Tokoyoda, K., McGrath, M. A., Raftery, M. J., Schonrich, G., Serra, A., Chang, H. D., Radbruch, A.*, and Dong, J.* (2014). Human memory T cells from the bone marrow are resting and maintain long-lasting systemic memory. Proc Natl Acad Sci USA 111, 9229-9234. * equal contribution
  9. Shinoda K, Tokoyoda K, Hanazawa A, Hayashizaki K, Zehentmeier S, Hosokawa H, Iwamura C, Koseki H, Tumes DJ, Radbruch A, Nakayama T. Type II membrane protein CD69 regulates the formation of resting T-helper memory. Proc Natl Acad Sci USA. 2012 May 8;109(19):7409-14
  10. Hiepe F, Dörner T, Hauser AE, Hoyer BF, Mei H, Radbruch A. Long-lived autoreactive plasma cells drive persistent autoimmune inflammation. Nat Rev Rheumatol. 2011 Mar; 7(3):170-8. Review
Radbruch lab
Immunological memory is a driver of rheumatic inflammation
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