Scientific DirectorProf. Dr. Andreas Radbruch
Prof. Dr. Andreas Radbruch
As Scientific Director, Andreas Radbruch is in charge of the thematic orientation of the biomedical research at the DRFZ since 1996. In addition, he has been Professor for Experimental Rheumatology at the Medical Faculty of the Humboldt University of Berlin (Charité) since 1998.Andreas Radbruch is in charge of the thematic orientation of the biomedical research at the DRFZ. He has been the Scientific Director of the DRFZ since 1996; in addition, he has been Professor for Experimental Rheumatology at the Medical Faculty of the Humboldt University of Berlin (Charité) since 1998.
His scientific carrier began with his biological studies at the universities of Bonn and Cologne, at first focussing on the isolation of antibody class switch variants and idiopathic variants of hybridoma cell lines as well as the underlying molecular mechanisms of somatic mutation. Subsequently, he was the first to prove on activated B cells that in vivo antibody class switch is carried out by the physiological mechanism of recombination. Andreas Radbruch was able to show that the class switch induced by recombination is controlled by certain cytokines and is directed at certain classes.
Since his move to the DRFZ, Andreas Radbruch has been dealing with the regulation of the antibody class switch, precisely the regulation of the antibody function by cytokines secreted by T lymphocytes. This class switch is an essential element of the immune reaction and also plays a decisive role in the development and molecular imprint of the immunological memory, one of the four current main research subjects of Andreas Radbruch. His further main research subjects are autoimmunity, inflammation and immune pathology, the biology of T and B lymphocytes as well as plasma cells and the development of immune technologies such as cytometry and cell sorting.
In their research, the DRFZ scientists around Andreas Radbruch combine advanced genetic methods in mice with cell-biological methods as well as system-biological approaches in order to decode the individual regulation variables and their interaction in the complex network of messengers and immune cells. A milestone in the research of the last few years was constituted by verifying that plasma cells in the medulla are extremely long-lived, contrary to what has long been postulated. Cytokines are also important in this respect: they keep the cells alive.
In addition, Andreas Radbruch maintains close cooperation with spin-off, independent biotechnological enterprises, in which the cell sorting and transfection technologies developed within the scope of the research projects are refined, and numerous clinics, in which these technologies are applied in the clinical research.
Andreas Radbruch has been author and/or co-author of more than 200 original publications and more than 90 reviews. He is holder of patents and patents pending and has received a great number of fellowships and awards, amongst others an Advanced Grant of the European Research Council (ERC).
Currently, Andreas Radbruch is spokesperson of the Section C (Life Sciences) of the Leibniz Association, president of the European Federation of Immunological Societies (EFIS) and Deputy Chairman of the Robert-Koch-Stiftung.
CV and Key Publications
- Since 1998 Professor (C4S) for Experimental Rheumatology at Charité Universitätsmedizin Berlin
- Since 1996 Scientific Director of the Leibniz Institute “Deutsches Rheuma-Forschungszentrum”
- 1990 – 1998 Professor (C3) for Genetics and Immunology, University of Cologne
- 1988 – 1989 Bayer-Lecturer at the Institute for Genetics of the University of Cologne
- 1987, 1988 Visiting Scientist at the University of Alabama, Birmingham, with Max Cooper
- 1982 – 1988 Assistant Professor, Institute for Genetics of the Cologne University
- 1980 – 1982 Research Assistant at the Institute for Genetics of the Cologne University
- 1988 Habilitation and Venia Legendi in Genetics and Immunology, University of Cologne
- 1980 Promotion to Dr. rer. nat., with Klaus Rajewsky, Institute for Genetics of the University of Cologne
- 1976 Diploma in biology (Dipl. Biol.) at the University of Bonn
- Chairman Scientific Advisory Council of the Robert Koch Foundation
- Advisory Board of the Institute for Biomedical Sciences (RIBS), Tokyo University of Science
- Expert Panel (“Fachkollegium”) 201 “Cell Biology”of the DFG (German Research Foundation)
- Council (Hochschulrat) of the University of Cologne
- Chair of the Scientific Advisory Board of the Research Institute “Georg Speyer Haus” (Frankfurt/Main)
- Chair of the Scientific Advisory Board of the Interdisciplinary Center for Clinical Research (IZKF) (Münster)
- 2019 – 2021 President of the European Federation of Immunological Societies (EFIS)
- Since 2015 Spokesman of Section C (Lifesciences) of the Leibniz Association
- 2014 – 2016 President of the International Society for Advancement of Cytometry (ISAC)
- 2012 – 2015 European Journal of Immunology (Chair of the Excecutive Editorial Board)
- Since 2010 Member of the European Molecular Biology Organization (EMBO)
- Since 2009 Member of the Berlin-Brandenburg Academy of Sciences (BBAW)
- 2009 – 2010 President of the German Society for Immunology
- Since 2009 Member of the German Academy of Sciences (Leopoldina)
- 2007 – 2008 President of the German Society of Rheumatology
- 1994 – 1996 President of the German Society of Cytometry
- Blondel Medal for Rheumatology (2017)
- Avery Landsteiner Award (2014)
- Carol Nachman Prize (2014)
- ERC Advanced Grant (2011-2016)
- Federal Cross of Merit of Germany (2008)
- Aronson Prize (2000)
- Karl-Heinz Beckurts Prize (Technology Transfer Award) (1994)
- 2018 – 2022 DFG SFB TRR 241
- 2017 – 2022 EU IMI2 “RTCure” – Lead of WP 3;
- 2017 – 2021 DFG SFB TRR130
- 2015 – 2019 BMBF “Neuroimmunology and Pain (NeuroImpa)“
- 2012 – 2016 DFG SFB 650
- 2011 – 2017 EU IMI “BTCure”
- 2011 – 2016 DFG SFB 633
- 2010 – 2016 DFG SPP 1468 “ImmunoBone”
- 2010 – 2013 BMBF “Imprinting of pathogenic memory (IMPAM)”
- 2010 – 2013 BMBF “ImmunoPain“
- Chang HD, Tokoyoda K, Radbruch A. Immunological memories of the bone marrow. Immunol Rev. 2018 May; 283(1):86-98. Review
- Siracusa F, McGrath MA, Maschmeyer P, Bardua M, Lehmann K, Heinz G, Durek P, Heinrich FF, Mashreghi MF, Chang HD, Tokoyoda K, Radbruch A. Nonfollicular reactivation of bone marrow resident memory CD4 T cells in immune clusters of the bone marrow. Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):1334-1339
- Maschmeyer P, Petkau G, Siracusa F, Zimmermann J, Zügel F, Kühl AA, Lehmann K, Schimmelpfennig S, Weber M, Haftmann C, Riedel R, Bardua M, Heinz GA, Tran CL, Hoyer BF, Hiepe F, Herzog S, Wittmann J, Rajewsky N, Melchers FG, Chang HD, Radbruch A, Mashreghi MF. Selective targeting of pro-inflammatory Th1 cells by microRNA-148a-specific antagomirs in vivo. J Autoimmun. 2018 May;89:41-52
- Siracusa F, Alp ÖS, Maschmeyer P, McGrath M, Mashreghi MF, Hojyo S, Chang HD, Tokoyoda K, Radbruch A. Maintenance of CD8(+) memory T lymphocytes in the spleen but not in the bone marrow is dependent on proliferation. Eur J Immunol. 2017 Nov;47(11):1900-1905
- Zimmermann J, Kühl AA, Weber M, Grün JR, Löffler J, Haftmann C, Riedel R, Maschmeyer P, Lehmann K, Westendorf K, Mashreghi MF, Löhning M, Mack M, Radbruch A, Chang HD. T-bet expression by Th cells promotes type 1 inflammation but is dispensable for colitis. Mucosal Immunol. 2016 Feb 17. doi: 10.1038/mi.2016.5.
- Alexander T, Sarfert R, Klotsche J, Kühl AA, Rubbert-Roth A, Lorenz HM, Rech J, Hoyer BF, Cheng Q, Waka A, Taddeo A, Wiesener M, Schett G, Burmester GR, Radbruch A, Hiepe F, Voll RE. The proteasome inhibitior bortezomib depletes plasma cells and ameliorates clinical manifestations of refractory systemic lupus erythematosus. Ann Rheum Dis. 2015 Jul;74(7):1474-8
- Haftmann C, Stittrich AB, Zimmermann J, Fang Z, Hradilkova K, Bardua M, Westendorf K, Heinz GA, Riedel R, Siede J, Lehmann K, Weinberger EE, Zimmel D, Lauer U, Häupl T, Sieper J, Backhaus M, Neumann C, Hoffmann U, Porstner M, Chen W, Grün JR, Baumgrass R, Matz M, Löhning M, Scheffold A, Wittmann J, Chang HD, Rajewsky N, Jäck HM, Radbruch A*, Mashreghi MF*. miR-148a is upregulated by Twist1 and T- bet and promotes Th1-cell survival by regulating the proapoptotic gene Bim. Eur J Immunol. 2015 Apr;45(4):1192-205., *equal contribution
- Okhrimenko, A., Grun, J.R., Westendorf, K., Fang, Z., Reinke, S., von Roth, P., Wassilew, G., Kuhl, A.A., Kudernatsch, R., Demski, S., Scheibenbogen, C., Tokoyoda, K., McGrath, M. A., Raftery, M. J., Schonrich, G., Serra, A., Chang, H. D., Radbruch, A.*, and Dong, J.* (2014). Human memory T cells from the bone marrow are resting and maintain long-lasting systemic memory. Proc Natl Acad Sci USA 111, 9229-9234. * equal contribution
- Shinoda K, Tokoyoda K, Hanazawa A, Hayashizaki K, Zehentmeier S, Hosokawa H, Iwamura C, Koseki H, Tumes DJ, Radbruch A, Nakayama T. Type II membrane protein CD69 regulates the formation of resting T-helper memory. Proc Natl Acad Sci USA. 2012 May 8;109(19):7409-14
- Hiepe F, Dörner T, Hauser AE, Hoyer BF, Mei H, Radbruch A. Long-lived autoreactive plasma cells drive persistent autoimmune inflammation. Nat Rev Rheumatol. 2011 Mar; 7(3):170-8. Review