Chronic Quiescence – maintenance of hematopoiesis and immunological memory in health and latent infection, and its disruption in chronic inflammation (CHROQ)

Leibniz Competition Collaborative Excellence

 
The project aims to investigate the molecular mechanism underlying the quiescence of hematopoietic stem cells (HSC) and memory lymphocytes in bone marrow niches. Quiescence of these cells is fundamental for hematological and immunological memory, which maintains chronic inflammatory diseases during their dormant states.
An international and interdisciplinary network of experts in stromal cell biology, haematology, and molecular cell biology, in particular RNA biology, will complement the expertise of the Leibniz institutes DRFZ and Forschungszentrum Borstel. The consortium combines experimental in vivo and ex vivo approaches to define the signals inducing, maintaining or terminating quiescence, the integration of signalling pathways in the hematopoietic and immune cells, and the targets of signalling, which confer long-lasting quiescence.

Project term: 2019 – 2023