FOR 5560 – Interactions between metabolism and signalling in B cells

Interactions between metabolism and signalling in B cells

The “Forschergruppe” investigates the interaction between metabolism and signal transduction in the regulation of B cells. By investigating immunometabolism, new regulatory mechanisms will be identified that influence B cell reactions. The research focusses on two main aspects: First, how the microenvironment influences B cell function, particularly in immunological niches such as the germinal centre, bone marrow or inflamed kidneys, by studying access to nutrients and oxygen. In a second complementary research focus, the molecular basis of the interplay between signalling and metabolism will be defined.

The DRFZ sub-project focuses on the spatio-temporal dynamics of calcium signalling and metabolism in germinal centre B cells.