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Pitzer Lab Osteoarthritis Research
Prof. Dr. Max Löhning

Pitzer Lab Osteoarthritis Research

Prof. Dr. Max Löhning

Medizinischen Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie
Charité - Universitätsmedizin Berlin
max.loehning@charite.de
&
Deutsches Rheuma-Forschungszentrum Berlin (DRFZ)
Ein Institut der Leibniz-Gemeinschaft
Charitéplatz 1
10117 Berlin
Phone: +49/ 30/ 28460-760, Lab: -700/-711/-729 Fax: +49/ 30/ 28460-773 loehning@drfz.de
Löhning lab
Biological regeneration of cartilage by selection and reprogramming of chondrocytes

CV and Key Publications

Scientific Career
  • Since 2015 University Professor (W3, permanent) and Head of Pitzer Laboratory of Osteoarthritis Research at Charité – Universitätsmedizin Berlin and DRFZ Berlin
  • 2013 – 2014 Offer of W3 Professorship position and Head of Department of Immunology at Universitätsmedizin Greifswald; 2014 declined
  • 2012 – 2015 University Professor (W2, permanent) of Experimental Immunology, Charité, Berlin
  • 2006 – 2011 Lichtenberg Professor (W1) at Charité, funded by Volkswagen Foundation
  • 2002 – 2006 Postdoctoral fellow with R.M. Zinkernagel and H. Hengartner at the Institute of Experimental Immunology, ETH and University Hospital Zurich, Switzerland, funded by Ernst Schering Foundation
  • 2000 – 2002 Postdoctoral fellow with A. Radbruch at DRFZ Berlin
  • 1999 – 2000 Research fellow with W.E. Paul at NIH, NIAID, Bethesda, MD, and with K.M. Murphy at Washington University-School of Medicine, St. Louis, MO, USA
Education
  • 1996 – 2000 PhD thesis as fellow of German National Academic Foundation at the Institute of Genetics, University of Cologne; 2000 Dr. rer. nat. (“very good, with distinction”)
  • 1990 – 1996 Biology studies as fellow of German National Academic Foundation (Studienstiftung des deutschen Volkes) at the University of Mainz; 1996 Diploma (“with distinction”)
Boards
  • Since 2017 Board member and Council member of Berlin-Brandenburg Academy of Sciences
  • Since 2017 Spokesperson of the class Biological Sciences and Medicine of Berlin-Brandenburg Academy of Sciences (BBAW); 2014–2017 Vice-Spokesperson
  • Since 2017 Board member of Deutsche Rheumastiftung of German Society for Rheumatology (DGRh)
  • Since 2014 Founder and Board member of BIH Young Science at Berlin Institute of Health (BIH)
  • 2013 – 2016 Head of the Integrated Research Training Group (iRTG, GRK) of Collaborative Research Center 650 (SFB 650) at Charité, Berlin
  • Since 2012 Vice-Director of Research Center ImmunoSciences at Charité; 2006 Board member
  • Since 2009 Board member of ZIBI Graduate School at Humboldt-Universität zu Berlin
  • 2009 – 2016 Board member and Scientific Secretary (2009–2011) of SFB 650 at Charité
  • Since 2007 Board member of the International Max Planck Research School for Infectious Diseases and Immunology (IMPRS-IDI), Berlin
Awards
  • Since 2013 Member of Berlin-Brandenburg Academy of Sciences (BBAW)
  • 2010 Georges-Köhler-Prize of the German Society for Immunology (DGfI)
  • 2006 – 2015 Lichtenberg Professorship of Experimental Immunology at Charité funded by Volkswagen Foundation
  • 2004 – 2009 Member of Die Junge Akademie (The German Young Academy) at the BBAW and the German National Academy of Sciences Leopoldina
  • 2004 Robert-Koch-Postdoctoral-Prize of Robert Koch Foundation
  • 2002 – 2004 Postdoctoral fellowship of Ernst Schering Foundation
  • 2000 Avrion-Mitchison-Prize for Rheumatology of Ernst Schering Foundation
  • 2000 Otto-Westphal-PhD-Prize of the German Society for Immunology
  • 1993 – 2000 Diploma and PhD fellowships of the German National Academic Foundation
Third Party Funding

Selection from 2012 – ongoing

  • 2019 – 2021 German Research Foundation (DFG), LO 1542/4-1: Dissection of cell-cell communication networks in chronic viral infection by kinetic immune-cell monitoring and mathematical modeling.
  • 2016 – 2018 Swiss National Science Foundation (SNF), Sinergia grant CRSII3_160772: The alarmin interleukin-33 in infection, immunity and autoimmunity.
  • 2015 – 2020 Willy Robert Pitzer Foundation, Pitzer Laboratory of Osteoarthritis Research.
  • 2006 – 2015 Volkswagen Foundation, Lichtenberg Professorship of Experimental Immunology.
  • 2013 – 2017 EU, FP7, Marie Curie Initial Training Network (ITN), Quantitative T Cell Immunology (QuanTI), TP 6: Cytokine memory in T cells.
  • 2013 – 2016 DFG, SFB 650, Head of iRTG Suppression of unwanted immune responses.
  • 2013 – 2016 DFG, SFB 650, TP 28: Suppression of autoreactive T cell responses by Th2 cells.
  • 2013 – 2016 DFG, LO 1542/3-1: Transcriptional programming and re-programming of pro-inflam-matory T helper 1 cells.
  • 2013 – 2015 BMBF, e:Bio – T-Sys, project WP 3 TP 5: Interplay of epigenetic and transcriptional imprinting of T helper cell fate.
  • 2012 – 2014 DFG, Epigenetic signatures of memory T cells and their functional relevance. Joint project with A. Hamann, Charité Berlin.
Key Publications
  1. Peine, M., R.M. Marek & M. Löhning. 2016. IL-33 in T cell differentiation, function, and immune homeostasis. Trends Immunol. 37, 321-33.
  2. Bhattacharya, A., A.N. Hegazy, N. Deigendesch, L. Kosack, J. Cupovic, R.K. Kandasamy, A. Hildebrandt, D. Merkler, A.A. Kühl, … G. Superti-Furga, J. Colinge, B. Ludewig, M. Löhning* & A. Bergthaler*. 2015. Superoxide dismutase 1 protects hepatocytes from type I interferon-driven oxidative damage. Immunity 43, 974-86. )*Shared senior authors.
  3. Baumann, C., W.V. Bonilla, A. Fröhlich, C. Helmstetter, M. Peine, A.N. Hegazy, D.D. Pinschewer & M. Löhning. 2015. T-bet– and Stat4–dependent IL-33 receptor expression directly promotes antiviral Th1 cell responses. Proc. Natl. Acad. Sci. USA 112, 4056-61.
  4. Helmstetter, C., M. Flossdorf, M. Peine, A. Kupz, J. Zhu, A.N. Hegazy, M.A. Duque-Correa, Q. Zhang, Y. Vainshtein, A. Radbruch, S.H. Kaufmann, W.E. Paul, T. Höfer & M. Löhning. 2015. Individual T helper cells have a quantitative cytokine memory. Immunity 42, 108-22.
  5. Schiering, C., T. Krausgruber, A. Chomka, A. Fröhlich, K. Adelmann, E.A. Wohlfert, A.N. Hegazy, O. Harrison, T. Griseri, J. Bollrath, M. Löhning, Y. Belkaid, P.G. Fallon & F. Powrie. 2014. The alarmin interleukin-33 promotes regulatory T cell function in the intestine. Nature 513, 564-8.
  6. Peine, M., S. Rausch, C. Helmstetter, A. Fröhlich, A.N. Hegazy, A.A. Kühl, C.G. Grevelding, T. Höfer, S. Hartmann & M. Löhning. 2013. Stable T bet+GATA-3+ Th1/Th2 hybrid cells arise in vivo, can develop directly from naive precursors, and limit immunopathologic inflammation. PLoS Biol. 11, e1001633.
  7. Bonilla, W.V., A. Fröhlich, K. Senn, S. Kallert, M. Fernandez, S. Johnson, M. Kreutzfeldt, A.N. Hegazy, C. Schrick, P.G. Fallon, R. Klemenz, S. Nakae, H. Adler, D. Merkler, M. Löhning* & D.D. Pinschewer*. 2012. The alarmin in-terleukin-33 drives protective antiviral CD8+ T cell responses. Science 335, 984-9. )*Shared senior & corresponding authors.
  8. Chu, V.T., A. Fröhlich, G. Steinhauser, T. Scheel, T. Roch, S. Fillatreau, J.J. Lee, M. Löhning & C. Berek. 2011. Eosinophils are required for the maintenance of plasma cells in the bone marrow. Nature Immunol. 12, 151-9.
  9. Hegazy, A.N., M. Peine, C. Helmstetter, I. Panse, A. Fröhlich, A. Bergthaler, L. Flatz, D.D. Pinschewer, A. Radbruch & M. Löhning. 2010. Interferons direct Th2 cell reprogramming to generate a stable GATA-3+T-bet+ cell subset with combined Th2 and Th1 cell functions. Immunity 32, 116-28.
  10. Löhning, M., A.N. Hegazy, D.D. Pinschewer, D. Busse, K.S. Lang, T. Höfer, A. Radbruch, R.M. Zinkernagel & H. Hengartner. 2008. Long-lived virus-reactive memory T cells generated from purified cytokine-secreting T helper type 1 and type 2 effectors. J. Exp. Med. 205, 53-61.