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Prof. Dr. Max Löhning

Programmbereich 3, PB 3 – Systemrheumatologie

Gruppenleitung: Pitzer-Labor für Athroseforschung

Liaisonarbeitsgruppe mit Charité - Rheumatologie und Klinische Immunologie

+49/ 30/ 28460-760, Lab: -700/-711/-729

loehning@drfz.de

Scientific Background

Since 2015rnFull Professor (W3), Head of Pitzer Laboratory of Osteoarthritis Researchrnrn2013 – 2014rnOffer of Head of Department of Immunology (W3) at Universitätsmedizin Greifswald; 2014 declinedrnrn2006 – 2015rnLichtenberg Professor (W2) of Experimental Immunology, Charité, Berlinrnrn2002 – 2006rnPostdoctoral fellow with R.M. Zinkernagel and H. Hengartner at the Institute of Experimental Immunology, ETH and University Hospital Zurich, Switzerlandrnrn2000 – 2002rnPostdoctoral fellow with A. Radbruch at DRFZ Berlin

1996 – 2000rnPhD thesis at the Institute of Genetics, Univ. of Cologne; 2000 Dr. rer. nat.rnrn1990 – 1996rnBiology studies at the University of Mainz; 1996 Diploma (“with distinction”)

Since 2020rnGuest Professor at Goethe-Universität Frankfurt/Main, Medical FacultyrnrnSince 2013rnMember of Berlin-Brandenburg Academy of Sciences (BBAW)rnrn2004 – 2009rnMember of Die Junge Akademie (The German Young Academy) at the BBAW and the German National Academy of Sciences Leopoldina

Since 2023rnChair of the Foundation Council of Schering FoundationrnrnSince 2017rnBoard member and Council member of Berlin-Brandenburg Academy of Sciences (BBAW)rnrnSince 2017rnSpokesperson of the class Biological Sciences and Medicine of Berlin-Brandenburg Academy of Sciences (BBAW); 2014–2017 Vice-SpokespersonrnrnSince 2017rnBoard member of Deutsche Rheumastiftung of German Society for Rheumatology (DGRh)rnrnSince 2012rnVice-Director of Research Center ImmunoSciences (RCIS) at Charité

2010rnGeorges-Köhler-Prize of the German Society for Immunology (DGfI)rnrn2006 – 2015rnLichtenberg Professorship at Charité funded by Volkswagen Foundationrnrn2004rnRobert-Koch-Postdoctoral-Prize of Robert Koch Foundationrnrn2002 – 2004rnPostdoctoral fellowship of Ernst Schering Foundationrnrn2002rnAvrion-Mitchison-Prize for Rheumatologyrnrn2000rnOtto-Westphal-PhD-Prize of the German Society for Immunologyrnrn1993 – 2000rnDiploma and PhD fellowships of the German National Academic Foundation

TOP 5 PUBLICATIONS

Plasticity and lineage commitment of individual TH1 cells are determined by stable T-bet expression quantities Hegazy, A.N., C. Peine, D. Niesen, I. Panse, Y. Vainshtein, C. Kommer, Q. Zhang, T.M. Brunner, M. Peine, A. Fröhlich, N. Ishaque, R.M. Marek, J. Zhu, T. Höfer u0026 M. Löhning. Plasticity and lineage commitment of individual Th1 cells are determined by stable T-bet expression quantities. Science Advances 2024, 10:eadk2693. doi: 10.1126/sciadv.adk2693.
A type 1 immunity-restricted promoter of the IL-33 receptor gene directs antiviral T-cell responses Brunner*, T.M., S. Serve*, A.F. Marx, J. Fadejeva, P. Saikali, M. Dzamukova, N. Durán-Hernández, C. Kommer, F. Heinrich, P. Durek, G.A. Heinz, T. Höfer, M.F. Mashreghi, R. Kühn, D.D. Pinschewer u0026 M. Löhning. A type 1 immunity-restricted promoter of the IL-33 receptor gene directs antiviral T-cell responses. Nature Immunology 2024, 25:256-267. doi: 10.1038/s41590-023-01697-6. (*Shared first authors). [Paper of the Months of Charité Faculty Board, March 2024]
NOS inhibition reverses TLR2-induced chondrocyte dysfunction and attenuates age-related osteoarthritis Shen, P., S. Serve, P. Wu, X. Liu, Y. Dai, N. Durán-Hernández, D.T.M. Nguyen, M. Fuchs, T. Maleitzke, M.J. Reisener, M. Dzamukova, K. Nussbaumer, T.M. Brunner, Y. Li, V. Holecska, G.A. Heinz, F. Heinrich, P. Durek, G. Katsoula, C. Gwinner, T. Jung, E. Zeggini, T. Winkler, M.F. Mashreghi, M. Pumberger, C. Perka u0026 M. Löhning. NOS inhibition reverses TLR2-induced chondrocyte dysfunction and attenuates age-related osteoarthritis. Proceedings of the National Academy of Sciences USA 2023, 120:e2207993120. doi: 10.1073/pnas.2207993120.
The alarmin interleukin-33 promotes the expansion and preserves the stemness of Tcf-1+ CD8+ T cells in chronic viral infection Marx*, A.F., S.M. Kallert*, T.M. Brunner*, J.A. Villegas, F. Geier, J. Fixemer, T. Abreu-Mota, P. Reuther, W.V. Bonilla, J. Fadejeva, M. Kreutzfeldt, I. Wagner, P. Aparicio-Domingo, L. Scarpellino, M. Charmoy, D.T. Utzschneider, C. Hagedorn, M. Lu, K. Cornille, K. Stauffer, F. Kreppel, D. Merkler, D. Zehn, W. Held, S.A. Luther, M. Löhning** u0026 D.D. Pinschewer**. The alarmin interleukin-33 promotes the expansion and preserves the stemness of Tcf-1+ CD8+ T cells in chronic viral infection. Immunity 2023, 56:813-828. doi: 10.1016/j.immuni.2023.01.029. (*Shared first authors, **Shared corresponding authors).
Mechanical forces couple bone matrix mineralization with inhibition of angiogenesis to limit adolescent bone growth Dzamukova, M., T. Brunner, J. Miotla-Zarebska, F. Heinrich, L. Brylka, M.F. Mashreghi, A. Kusumbe, R. Kühn, T. Schinke, T. Vincent u0026 M. Löhning. Mechanical forces couple bone matrix mineralization with inhibition of angiogenesis to limit adolescent bone growth. Nature Communications 2022, 13:3059. doi: 10.1038/s41467-022-30618-8. t[Avrion-Mitchison-Prize for Rheumatology to Maria Dzamukova, Dec. 2022]

AG Löhning

Pitzer-Labor Arthroseforschung: Molekulare Schalter zur biologischen Gelenkregeneration

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