Prof. Dr. rer. nat. Raluca Niesner

Programmbereich 1, PB 1 – Zell- und Gewebe-Rheumatologie

Gruppenleitung: Biophysikalische Analytik

Liaisonarbeitsgruppe mit FU Berlin

Tel: +49 (0)30 28460-683

niesner@drfz.de

Scientific Background

Scientific Career

2018
W2-Professorship “Dynamic and functional in vivo imaging”, Freie Universität Berlin

2016
Tenured group leader “Biophysical Analytics”, DRFZ, Berlin

2013
Group leader “Biophysical Analytics” – defended W2-professorship offer at Otto-von-Guericke University Magdeburg

2010
Junior group leader “Biophysical Analytics”, DRFZ, Berlin; co-leader of the central lab for “Advanced imaging” with Anja Hauser

2008
Researcher (DFG grant for own position) at Charité, Berlin and Max-Delbrück-Center for Molecular Medicine, Berlin, Prof. Frauke Zipp (Neurology)

2005
PostDoc at Helmholtz Zentrum für Infektionsforschung (HZI) and Institute for Physical and Theoretical Chemistry, TU Braunschweig

Education

2005
Dr. rer. nat. defense „Advancements in time-resolved two-photon microscopy: theory and applications”, Prof. K.-H. Gericke, Physical and Theoretical Chemistry, TU Braunschweig, “summa cum laudae”

2001
Dipl.-Chem., TU Braunschweig

1998
Erasmus-Socrates Student

1996
Study of Chemistry at University of Bucharest, Romania

Professional Activities

2018 – 2020
Vice-president German Society for Cytometry (DGfZ)

2020 – 2022
President German Society for Cytometry (DGfZ)

Society Memberships

German Society of Immunology (DGfI), German Society of Rheumatology (DGRh), German Society of Internal Medicine (DGIM)

ESMI – European Society for Molecular Imaging (member since 2019)

DGfZ (2018-2020 vice-president; 2020-2022 president; since 2022 board member)

ISAC (member since 2011)

Fellowships and Awards

2008 – 2011
DFG grant for the own position

2009 – 2011
Rahel-Hirsch Habilitation Fellowship (Charité – Universitätsmedizin, Berlin)

2018 – 2019
Young Leaders in Science (Schering Stiftung)

2015 – 2019
Marylou Ingram Scholar: Leadership in Cytometry (International Society for Advancement in Cytometry)

TOP PUBLICATIONS

Tracking CNS and systemic sources of oxidative stress during the course of chronic neuroinflammation Mossakowski et al, 2015 Acta Neuropathologica (Letztautorin mit Helena Radbruch) : Tracking CNS and systemic sources of oxidative stress during the course of chronic neuroinflammation. Mossakowski AA, Pohlan J, Bremer D, Lindquist R, Millward JM, Bock M, Pollok K, Mothes R, Viohl L, Radbruch M, Gerhard J, Bellmann-Strobl J, Behrens J, Infante-Duarte C, Mähler A, Boschmann M, Rinnenthal JL, Füchtemeier M, Herz J, Pache FC, Bardua M, Priller J, Hauser AE, Paul F, Niesner R, Radbruch H.Acta Neuropathol. 2015 Dec;130(6):799-814. doi: 10.1007/s00401-015-1497-x.

Longitudinal intravital imaging of the femoral bone marrow reveals plasticity within marrow vasculature Reismann et al, 2017 Nature Communications (Letztautorin mit Anja) : Longitudinal intravital imaging of the femoral bone marrow reveals plasticity within marrow vasculature. Reismann D, Stefanowski J, Günther R, Rakhymzhan A, Matthys R, Nützi R, Zehentmeier S, Schmidt-Bleek K, Petkau G, Chang HD, Naundorf S, Winter Y, Melchers F, Duda G, Hauser AE, Niesner RA. Nat Commun. 2017 Dec 18;8(1):2153. doi: 10.1038/s41467-017-01538-9

Expanding two-photon intravital microscopy to the infrared by means of optical parametric oscillator Herz et al, 2010 Biophysical Journal (Letztautorin) : Expanding two-photon intravital microscopy to the infrared by means of optical parametric oscillator. Herz J, Siffrin V, Hauser AE, Brandt AU, Leuenberger T, Radbruch H, Zipp F, Niesner RA. Biophys J. 2010 Feb 17;98(4):715-23. doi: 10.1016/j.bpj.2009.10.035.

Intravital quantification reveals dynamic calcium concentration changes across B cell differentiation stages Ulbricht et al, 2021, eLife (Letztautorin mit Anja): Intravital quantification reveals dynamic calcium concentration changes across B cell differentiation stages. Ulbricht C, Leben R, Rakhymzhan A, Kirchhoff F, Nitschke L, Radbruch H, Niesner RA, Hauser AE. Elife. 2021 Mar 22;10:e56020. doi: 10.7554/eLife.56020.

MarShie: a clearing protocol for 3D analysis of single cells throughout the bone marrow at subcellular resolution Mertens et al, 2024 (Letztautorin mit Anja): MarShie: a clearing protocol for 3D analysis of single cells throughout the bone marrow at subcellular resolution. Mertens TF, Liebheit AT, Ehl J, Köhler R, Rakhymzhan A, Woehler A, Katthän L, Ebel G, Liublin W, Kasapi A, Triantafyllopoulou A, Schulz TJ, Niesner RA, Hauser AE.Nat Commun. 2024 Feb 26;15(1):1764. doi: 10.1038/s41467-024-45827-6.

Optimized intravital three-photon imaging of intact mouse tibia links plasma cell motility to functional states Rakhymzhan, A., Fiedler A.F., Günther, R., Domingue, S.R., Wooldridge, L., Leben, R., Cao, Y., Bias, A., Roodselaar, J., Köhler, R., Ulbricht, C., Heidelin, J., Andresen, V., Beckers, I., Haibel, A., Duda, G., Hauser, A.E.* & Niesner, R.A*. (2024). Optimized intravital three-photon imaging of intact mouse tibia links plasma cell motility to functional states. iScience, 27(10):110985. https://doi.org/10.1016/j.isci.2024.110985

Biophysikalische Analytik

AG Niesner

Scientific Background

TOP PUBLICATIONS

Biophysikalische Analytik

News

DRFZ-Forscherinnen am neuen Einstein-Zirkel beteiligt

Posterpreis für Ruth Leben

Einblicke in das Innere von Knochen

Projekte

Einstein-Zirkel "Spatial Biology in Cancer: Focus on Inflammation and Endothelial Cells in Bone Marrow"

FOR2165 – Regeneration im Alter

DFG SFB 1444 – Gesteuerte zelluläre Selbstorganisation zur Verbesserung der Knochenregeneration