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Lymphozytenentwicklung
Prof. Dr. Fritz Melchers

Lymphozytenentwicklung

Prof. Dr. Fritz Melchers

Deutsches Rheuma-Forschungszentrum Berlin
Ein Institut der Leibniz-Gemeinschaft
Charitéplatz 1
10117 Berlin
Tel: +49 30 28460 260 Fax: +49 30 28460 243 fritz.melchers@drfz.de
Link zur AG Melchers
Wie entwickeln sich Antikörper-produzierende B-Lymphozyten aus blutbildenden Stammzellen?

Wissenschaftlicher Werdegang und Publikationen

Wissenschaftlicher Werdegang
  • Since 2017 Senior Scientist and Group Leader, DRFZ
  • 2008 – 2016 Max Planck Fellow
  • 2003 – 2007 Senior Research Group Leader, Max Planck Institute for Infection Biology, Berlin
  • 1981 – 2001 Director, Basel Institute for Immunology, Basel, Switzerland
  • 1970 – 1980 Permanent Member, Basel Institute for Immunology, Basel, Switzerland
  • 1970 – 1971 Visiting Scientist, Department of Genetics, Stanford University Medical School
  • 1970 Visiting Scientist, Weizmann Institute, Rehovot, Israel
  • 1970 Senior Research Assistant, Max Planck Institute for Molecular Genetics, Berlin
  • 1968 – 1969 Postdoctoral Fellow, Max Planck Institute for Molecular Genetics, Berlin
  • 1965 – 1967 Research Associate, Salk Institute for Biological Studies, La Jolla, CA, USA (Fulbright)

Werdegang

  • 1971 Dr. rer. nat. habil., Venia legendi, University of Freiburg i.Br., Faculty of Biology
  • 1964 Ph.D. (Dr. rer. nat.), University of Cologne, Germany
  • 1961 Dipl. chem., University of Cologne, Germany
Boards (ausgewählt)

2010 – 2018 Tuberculosis Vaccine Initiative, Amsterdam

2003 – 2010 Member and Vice-President, University Council Hannover Medical School, Germany

2002 – 2014 4-Antibody GmbH, Basel, Switzerland, Co-founder

1998 – 2001 President, IUIS (International Union of Immunological Societies)

1996 – 2003 Member “Universitätsrat“, University of Basel, Switzerland

1993 – 1996 Nationaler Forschungsrat der Schweiz, Bern, Switzerland

1992 – 1999 Max Delbrück Center for Molecular Medicine, Berlin-Buch, Germany

1986 – 1996 Paul Ehrlich Foundation, Frankfurt am Main, Germany

1986 – 2001 Deutsches Rheuma-Forschungszentrum, Berlin, Germany

Mitgliedschaften

Academia Europea

Leopoldina

Norwegian Academy of Science and Letters

Swiss Academy of Medical Sciences

American Academy for Arts and Science

Austrian Academy of Sciences

Auszeichnungen

2017 Cothenius Medal, Leopoldina

2009 M.D.h.c. Medical University Innsbruck, Austria

2007 Novartis Prize for Basic Immunology

2007 M.D.h.c. University of Würzburg, Germany

2006 Ph.D.h.c. University of Leipzig, Germany

2003 M.D.h.c., University of Erlangen- Nuremberg, Germany

2002 Gaikokujin Chomei Kenkyu-shu (Eminent Scientist) Award of the Japanese Society for the Promotion of Science (JSPS) at the University of Tokyo School of Medicine

2002 External Scientific Member, Max Planck-Institute for Infection Biology, Berlin

2002 Emil von Behring Preis, Marburg, Germany

2001 Honorary Professor, Medical Faculty, University of Innsbruck, Austria

2000 San Marino Prize 2000

1997 Max Delbrück Medal, MDC, Berlin, Germany

1996 Robert-Koch Prize, Bonn, Germany

1996 Prausnitz-Medaille, Collegium Internationale Allergologicum (CIA), Vienna

1995 Bundesverdienstkreuz 1. Klasse der Bundesrepublik Deutschland

1994 Ph.D.h.c., Medical College, Thomas Jefferson University, Philadelphia, USA

1990 M.D.h.c., University of Turku, Finland

1988 Commendatore dell Ordine di Sant’ Agata, San Marino

1978 Honorary Professor, Faculty of Biology, Heidelberg University, Germany

Ausgewählte Publikationen

1. Kawano Y, Petkau G, Stehle C, Durek P, Heinz GA, Tanimoto K, Karasuyama H, Mashreghi MF, Romagnani C, Melchers F. Stable lines and clones of long-term proliferating normal, genetically unmodified murine common lymphoid progenitors. Blood. 2018 May 3;131(18):2026-2035.

2. Petkau G, Kawano Y, Wolf I, Knoll M, Melchers F. MiR221 promotes precursor B-cell retention in the bone marrow by amplifying the PI3K-signaling pathway in mice. Eur J Immunol. 2018 Mar 5. doi: 10.1002/eji.201747354.

3. Tornack J, Kawano Y, Garbi N, Hämmerling GJ, Melchers F, Tsuneto M. Flt3 ligand-eGFP-reporter expression characterizes functionally distinct subpopulations of CD150+ long-term repopulating murine hematopoietic stem cells. Eur J Immunol. 2017 Sep;47(9):1477-1487.

4. Wolf I, Bouquet C, Naumann F, Melchers F. Generation of precursor, immature, and mature murine B1-cell lines from c-myc/bcl-xL-overexpressing pre-BI cells. Eur J Immunol. 2017 May;47(5):911-920. doi: 10.1002/eji.201746937. Epub 2017 Apr 6.

5. Tornack J, Reece ST, Bauer WM, Vogelzang A, Bandermann S, Zedler U, Stingl G, Kaufmann SH, Melchers F. Human and Mouse Hematopoietic Stem Cells Are a Depot for Dormant Mycobacterium tuberculosis. PLoS One. 2017 Jan 3;12(1):e0169119. doi: 10.1371/journal.pone.0169119. eCollection 2017.

6. Wolf I, Bouquet C, Melchers F. cDNA-library testing identifies transforming genes cooperating with c-myc in mouse pre-B cells. Eur J Immunol. 2016 Nov;46(11):2555-2565.

7. Kawano Y, Petkau G, Wolf I, Tornack J, Melchers F. IL-7 and immobilized Kit-ligand stimulate serum- and stromal cell-free cultures of precursor B-cell lines and clones. Eur J Immunol. 2017 Jan;47(1):206-212. doi: 10.1002/eji.201646677. Epub 2016 Nov 11.

8. Kajikhina K, Melchers F, Tsuneto M. Chemokine polyreactivity of IL7Rα+CSF-1R+ lympho-myeloid progenitors in the developing fetal liver. Sci Rep. 2015 Aug 3;5:12817.

9. Funakoshi S, Shimizu T, Numata O, Ato M, Melchers F, Ohnishi K. BILL-cadherin/cadherin-17 contributes to the survival of memory B cells. PLoS One. 2015 Jan 22;10(1):e0117566. doi: 10.1371/journal.pone.0117566. eCollection 2015.

10.Knoll M, Simmons S, Bouquet C, Grün JR, Melchers F. miR-221 redirects precursor B cells to the BM and regulates their residence. Eur J Immunol. 2013 Sep;43(9):2497-506. doi: 10.1002/eji.201343367. Epub 2013 Jul 8