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Prof. Dr. med. Falk Hiepe

Autoimmunologie

Liaisonarbeitsgruppe mit Charité - Rheumatologie und Klinische Immunologie

Tel: +49 (0)30 450 513 082

falk.hiepe@charite.de

Senior Scientific Advisor

Scientific Background

Since 2019 Senior Professor, Charité – Universitätsmedizin Berlin
1997-2019 Full Professor of Rheumatology and Clinical Immunology, Charité – Universitätsmedizin Berlin
1997-2024 Group Leader German Rheumatology Research Center Berlin, a Leibniz Institute, Autoimmunology Group
1993-2019 Deputy Director, Department of Rheumatology and Clin. Immunology, Charité – Universitätsmedizin Berlin
1995 Research Fellow, W. M. Keck Autoimmune Disease Center (Head: E.M. Tan), The Scripps Research Institute, La Jolla, CA, USA
1988 Completed postdoctoral dissertation (habilitation, prerequisite for professorship) at the Humboldt University in Berlin
1987 Visiting Professor at the Second Dept. of Medicine, Teikyo University and Department of Medicine; Physical Therapy (Kazuhiko Yamamoto’s Lab), University of Tokyo, Japan
1977 degree thesis (Dr. med.), Faculty of Medicine, Humboldt University, Berlin)
1976 Diploma (Dipl.-Med.), Faculty of Medicine, Humboldt University, Berlin

1994 Specialization in Rheumatology
1983 Specialization in Internal Medicine
1978-1983 Resident Department of Internal Medicine, Charité Berlin, Germany
1971-1976 Study of Medicine, Humboldt-University Berlin, Germany

Since 2014 Chair,  Deutsche Gesellschaft für Lupus-Forschung
Since 2000 IUIS/WHO/AF/CDC Committee for the Standardization of Autoantibodies in Rheumatic and Related Disease,
International Advisory Board of Modern Rheumatology,
The Japan Rheumatism Association
Speaker, Arbeitskreis „Extrakorporale Therapieverfahren und Stammzelltherapie“, DGRh
2002-2014 Drug Commission of the German Medical Association

The German Society for Rheumatology,
The German Society for Immunology,
The Henry Kunkel Society, Deutsche Gesellschaft für Lupus-Forschung,
EBMT working party “autoimmune diseases”,
Rheuma-Liga Berlin e.V., Gesellschaft für Natur- und Heilkunde in Berlin,
Gesellschaft zur Förderung der Immundiagnostik e.V.,
Freunde und Förderer der Charité

Award Wolfgang-Schulze Foundation,
EULAR-award of EWRR,
Ideenwettbewerb Deutsche Rheumastiftung,
Humboldt Award for Best Diploma,
Research Award Charité Hospital

News

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TOP 5 PUBLICATIONS

Selective depletion of plasma cells in vivo based on the specificity of their secreted antibodies Cheng, Q., A. Pelz, A. Taddeo, L. Khodadadi, J. Klotsche, B. F. Hoyer, T. Alexander, A. Thiel, G. R. Burmester, A. Radbruch, and F. Hiepe. 2020. Selective depletion of plasma cells in vivo based on the specificity of their secreted antibodies. Eur J Immunol 50: 284-291.
Long-lived autoreactive plasma cells drive persistent autoimmune inflammation Hiepe, F., T. Dörner, A.E. Hauser, B.F. Hoyer, H. Mei, and A. Radbruch. 2011. Long-lived autoreactive plasma cells drive persistent autoimmune inflammation. Nat Rev Rheumatol 7:170-178.
Depletion of autoreactive immunologic memory followed by autologous hematopoietic stem cell transplantation in patients with refractory SLE induces long-term remission through de novo generation of a juvenile and tolerant immune system Alexander, T., A. Thiel, O. Rosen, G. Massenkeil, A. Sattler, S. Kohler, H. Mei, H. Radtke, E. Gromnica-Ihle, G. R. Burmester, R. Arnold, A. Radbruch, and F. Hiepe. 2009. Depletion of autoreactive immunologic memory followed by autologous hematopoietic stem cell transplantation in patients with refractory SLE induces long-term remission through de novo generation of a juvenile and tolerant immune system. Blood 113: 214-223
Short-lived plasmablasts and long-lived plasma cells contribute to chronic humoral autoimmunity in NZB/W mice Hoyer, B. F., K. Moser, A. E. Hauser, A. Peddinghaus, C. Voigt, D. Eilat, A. Radbruch, F. Hiepe*, and R. A. Manz*. 2004. Short-lived plasmablasts and long-lived plasma cells contribute to chronic humoral autoimmunity in NZB/W mice. The Journal of experimental medicine 199: 1577-1584. *contributed equally
A novel epitope on the C-terminus of SmD1 is recognized by the majority of sera from patients with systemic lupus erythematosus. Riemekasten, G., J. Marell, G. Trebeljahr, R. Klein, G. Hausdorf, T. Häupl, J. Schneider-Mergener, G. R. Burmester, and F. Hiepe. 1998. A novel epitope on the C-terminus of SmD1 is recognized by the majority of sera from patients with systemic lupus erythematosus. J Clin Invest 102: 754-763.