Pathophysiology of Rheumatic Inflammation

Programme area 1
Head: Prof. Dr. Eicke Latz

How are rheumatic inflammations initiated and what maintains them and causes chronicity? How can they be cured in a targeted and definitive way? Which therapy works best for the individual patient?

At the cellular and molecular level, researchers at the DRFZ are looking for answers. The goal is to design selective and curative therapies.

Baumgrass lab

Regulation of cytokine expression in different T cell subsets

Latz lab

Understanding the links between innate immunity, chronic inflammatory disease and healthy ageing

Krönke lab

Investigating the molecular basis of inflammation and development of curative treatment approaches

Chang lab

How does the intestinal microbiota influence chronic inflammation?

Melchers lab

We intend to define molecular, cellular and functional properties of quiescent and of activated hematopoietic stem cells.

Radbruch lab

How does the immune system cause chronicity in rheumatic inflammation?

Buttgereit lab

How do immune cells adapt to oxygen and nutrient deficiencies in inflamed tissue?

Diefenbach lab

Development and function of the innate immune system

Dörner lab

Immunomodulatory approaches targeting autoreactive B lineage cells while leaving protective B memory intact

Hauser lab

We aim to understand the dynamic interactions of immune cells in the tissue context

Hegazy lab

Host-Microbiota interactions shape intestinal inflammation

Alexander/Hiepe lab

New ways of approaching treatment of autoimmune diseases

Niesner lab

We develop technologies for intravital imaging and live cell imaging to achieve new insights into chronic inflammatory processes

Polansky lab

How the structure of the genome shapes the immune system in health and disease

Romagnani lab

Identifying innate signals initiating and perpetuating chronic inflammation

Triantafyllopoulou lab

Macrophage biology and innate networks in chronic inflammatory diseases