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Glucocorticoids& Bioenergetica
Prof. Dr. med. Frank Buttgereit

Glucocorticoids& Bioenergetica

Prof. Dr. med. Frank Buttgereit

Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie an der Charité - Universitätsmedizin Berlin
Charitéplatz 1
10117 Berlin
Phone: +49 (0)30 450 513 125 Fax: +49 (0)30 450 513 917 frank.buttgereit@charite.de
Short Biosketch

Professor Frank Buttgereit

Frank Buttgereit is a senior consultant and deputy head of the Department of Rheumatology and Clinical Immunology at the Charité (CCM), University Medicine in Berlin. He also directs a liaison research group at the Deutsches Rheuma – Forschungszentrum (DRFZ).

He studied Medicine at the Humboldt University Berlin, Charité, became Specialist for Internal Medicine (Internist) in 1998 and Specialist for Rheumatology (Rheumatologist) in 1998, received his postdoctoral degree with lecturing qualification (Habilitation) in the faculty group Internal Medicine (Charité) and has held the position of Professor of Rheumatology at the Charité since 2002. Since 2012, he is appointed honorary professor for rheumatology at the Rosario University of Bogota, Colombia.

Dr. Buttgereit has expertise in the treatment of a wide variety of musculoskeletal and rheumatic diseases, including osteoporosis, osteoarthritis, rheumatoid arthritis, myositis, connective tissue diseases and different forms of vasculitis. He is internationally recognised for his work on mechanisms and clinical effects of glucocorticoids and on bioenergetics of immune functions. He has been principal investigator and site investigator in a variety of clinical studies on effects of anti-inflammatory and immunomodulatory agents in patients with rheumatic disease.

Dr. Buttgereit has been the recipient of several research awards and scholarships. He was or is currently on the editorial board of several journals, including Ann Rheum Dis, Rheumatology, Arthritis Research, and Z Rheumatol, and author of more than 330 publications. http://www.ncbi.nlm.nih.gov/pubmed?term=buttgereit-f

Scientific Career
  • Since 2003 Deputy Director, Department of Rheumatology and Clinical Immunology, Charité Universitätsmedizin Berlin
  • Since 2002 Professor of Rheumatology
  • 1997 Associate Professor, Senior Registrar, Medical School (Charité)
  • 1990 – 1996 Resident; Medical School (Charité), Humboldt-University, Berlin, Germany
  • 1988 – 1990 Military Service as M.D.
  • 1988 M.D., Medical School (Charité), Humboldt-University, Berlin, Germany
  • 1988 Final examination of Medical School (Charité), Humboldt-University, Berlin
  • 1982 – 1988 Medical School (Charité), Humboldt-University, Berlin, Germany
  • 1980 – 1982 Hospital Brandenburg
  • 1980 University-entrance Diploma, Germany
  • 1976 – 1980 College „Thomas Müntzer’’, Ziesar
Other Qualifications
  • Certificates of General Ultrasound, Arthrosonography and Echocardiography (DEGUM)
  • Certificate of PW- and CW-Ultrasound (DEGUM)
  • Certificate of X-ray Diagnostics (Sachkunde/Fachkunde: Skeleton & Emergency Medicine)
  • Certificate according to §15 GenTSV
  • Certificate Physical Therapy
  • Certificate Osteology
  • 1998 Rheumatology
  • 1996 Internal Medicine
Awards, Scholarships and Administrative Functions
  • 2012 – 2015 Member of the EULAR Scientific Program Committee
  • 2012 Friedrich Heuck Osteologie Preis (to Paula Kolar); Arthur-Vick-Preis (to Eric Röhner); Chugai Science Award (to Cindy Strehl)
  • 2012 Honorary Professorship, Rosario University, Bogota, Colombia
  • 2006 University of Sydney Short Term Visiting Fellowship
  • 2005 Josephine Delesse Stipendium of the DAdorW (Deutsche Akademie der Osteologischen und Rheumatologischen Wissenschaften)
  • 2002 Schuler-Award of the German Society of Rheumatology
  • 1996 Scholarship of the Deutscher Akademischer Austauschdienst
  • 1992 – 1994 Scholarship: ARC-Program (DAAD, British Council, Anglo-German-Foundation), Cambridge, United Kingdom
  • 1990 Scholarship of the Boehringer Ingelheim Foundation
  • 1988 Humboldt-Award for the Best Medical Thesis, Medical School (Charité), Humboldt-University, Berlin, Germany
Third Party Funding

Selection from 2011 – ongoing

  • 2016 – 2019 3DInJoMo: In vitro und in silico Modellierung der Immunpathogenese von Arthritiden zur effektiven Reduzierung der Zahl von Versuchstieren im Bereich der Therapieforschung, funded by Bundesministerium für Bildung und Forschung (BMBF)
  • 2016 – 2019 CoDiRA: patientenspezifische Diagnostik bei rheumatoider Arthritis, funded by Bundesministerium für Bildung und Forschung (BMBF)
  • 2014 – 2017 3DBoMo: Entwicklung eines 3D-Modells zur Simulation der initialen Frakturheilungsphase in vitro – Effektive Reduzierung von Tierversuchen in der Frakturheilungsforschung, funded by Bundesministerium für Bildung und Forschung (BMBF)
  • 2014 – 2016 PreTheraX, funded by medac, start
  • 2015 – 2020 EU project 634886 – GLORIA; funded by European Commission / Horizon2020
  • 2011 – 2015 Hydroxychloroquine (HCQ) in patients with inflammatory osteoarthritis (OA) of the hands (OA TREAT), funded by Bundesministerium für Bildung und Forschung (BMBF)
  • 2012 – 2015 EU Marie-Curie Initial Training Network: RAPID, funded by European Commission / 7th Framework Programme for Research
  • 2010 – 2014 Immunologische Aspekte der Knochenregeneration Berlin -Brandenburger Centrum für Regenerative Therapien (BCRT), funded by BMBF (2 funding periods)
  • 2010 – 2014 Development of Novel Nanotechnology Based Diagnostic Systems for Rheumatoid Arthritis and Osteoarthritis (NanoDiaRA), funded by European Commission / 7th Framework Programme for Research
Key Publications
  1. Gaber T, Strehl C, Buttgereit F (2017). Metabolic regulation of inflammation. Nature Reviews Rheumatology 13, 267-279.
  2. Buttgereit F, Mehta D, Kirwan J, Szechinski J, Boers M, Alten RE, Supronik J, Szombati I, Romer U, Witte S, Saag KG. Low-dose prednisone chronotherapy for rheumatoid arthritis: a randomised clinical trial (CAPRA-2). Ann Rheum Dis. 2013; 72:204-10
  3. Gaber T, Tran CL, Schellmann S, Hahne M, Strehl C, Hoff P, Radbruch A, Burmester GR, Buttgereit F (2013). Pathophysiological hypoxia affects the redox state and IL-2 signalling of human CD4+ T cells and concomitantly impairs survival and proliferation. European journal of immunology 43, 1588-1597.
  4. Brennan-Speranza T, Henneicke H, Gasparini S, Blankenstein K, Heinevetter U, Cogger V, Svistounov D, Zhang Y, Cooney G, Buttgereit F, Dunstan C, Gundberg C, Zhou H, Seibel M. Osteoblasts Mediate the Adverse Effects of Glucocorticoids on Fuel Metabolism. J Clin Invest. 2012; 122:4172-89
  5. Gaber T, Schellmann S, Erekul KB, Fangradt M, Tykwinska K, Hahne M, Maschmeyer P, Wagegg M, Stahn C, Kolar P, Dziurla R, Löhning M, Burmester GR, Buttgereit F. Macrophage migration inhibitory factor counter regulates dexamethasone-mediated suppression of hypoxia-inducible factor-1 alpha function and differentially influences human CD4+ T cell proliferation under hypoxia. J Immunol. 2011;186:764-74.
  6. Buttgereit F, Zhou H, Kalak R, Gaber T, Spies CM, Huscher D, Straub RH, Modzelewski J, Dunstan CR, Seibel MJ. Transgenic disruption of glucocorticoid signaling in mature osteoblasts and osteocytes attenuates K/BxN mouse serum-induced arthritis in vivo. Arthritis Rheum. 2009; 60, 1998-2007
  7. Buttgereit F, Doering G, Schaeffler A, Witte S, Sierakowski S, Gromnica-Ihle E, Jeka S, Krueger K, Szechinski J, Alten R. Efficacy of modified-release versus standard prednisone to reduce duration of morning stiffness of the joints in rheumatoid arthritis (CAPRA-1): a double-blind, randomised controlled trial. Lancet 2008; 371, 205-14
Buttgereit lab
How do immune cells adapt to oxygen and nutrient deficiencies in inflamed tissue?
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